ID   F8W7F7_HUMAN            Unreviewed;       178 AA.
AC   F8W7F7;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   16-JAN-2019, entry version 56.
DE   SubName: Full=Transmembrane emp24 domain-containing protein 4 {ECO:0000313|Ensembl:ENSP00000289577};
GN   Name=TMED4 {ECO:0000313|Ensembl:ENSP00000289577};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000289577, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000289577, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000289577}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003827};
CC       Single-pass type I membrane protein
CC       {ECO:0000256|RuleBase:RU003827}.
CC   -!- SIMILARITY: Belongs to the EMP24/GP25L family.
CC       {ECO:0000256|RuleBase:RU003827, ECO:0000256|SAAS:SAAS00561910}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC004938; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001289988.1; NM_001303059.1.
DR   UniGene; Hs.598832; -.
DR   ProteinModelPortal; F8W7F7; -.
DR   jPOST; F8W7F7; -.
DR   MaxQB; F8W7F7; -.
DR   PeptideAtlas; F8W7F7; -.
DR   PRIDE; F8W7F7; -.
DR   Ensembl; ENST00000289577; ENSP00000289577; ENSG00000158604.
DR   GeneID; 222068; -.
DR   UCSC; uc064dir.1; human.
DR   CTD; 222068; -.
DR   EuPathDB; HostDB:ENSG00000158604.14; -.
DR   HGNC; HGNC:22301; TMED4.
DR   OpenTargets; ENSG00000158604; -.
DR   GeneTree; ENSGT00940000159012; -.
DR   OrthoDB; 1294924at2759; -.
DR   ChiTaRS; TMED4; human.
DR   GenomeRNAi; 222068; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   ExpressionAtlas; F8W7F7; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR009038; GOLD_dom.
DR   InterPro; IPR015720; TMP21-related.
DR   PANTHER; PTHR22811; PTHR22811; 2.
DR   Pfam; PF01105; EMP24_GP25L; 2.
DR   SMART; SM01190; EMP24_GP25L; 1.
DR   PROSITE; PS50866; GOLD; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00561904, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:F8W7F7,
KW   ECO:0000213|MaxQB:F8W7F7, ECO:0000213|PeptideAtlas:F8W7F7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00561904,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00561904,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     29       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        30    178       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003385513.
FT   TRANSMEM    146    165       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       39    178       GOLD. {ECO:0000259|PROSITE:PS50866}.
SQ   SEQUENCE   178 AA;  20118 MW;  A1908E67F69FA00D CRC64;
     MAGVGAGPLR AMGRQALLLL ALCATGAQGL YFHIGETEKR CFIEEIPDET MVIGNYRTQM
     WDKQKEVFLP STPGLGMHVE VKDPDGKVVL SRQYGSEGRF TFTSHTPGDH QICLHSNSTR
     MALFAGGKLY REERFRLTSE STNQRVLWWS IAQTVILILT GIWQMRHLKS FFEAKKLV
//