ID   F8W7D1_HUMAN            Unreviewed;       503 AA.
AC   F8W7D1;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   05-DEC-2018, entry version 47.
DE   SubName: Full=C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 {ECO:0000313|Ensembl:ENSP00000373577};
GN   Name=CPAMD8 {ECO:0000313|Ensembl:ENSP00000373577};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000373577, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000373577, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000373577}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC008737; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC020908; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF456517; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF456518; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF511257; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; F8W7D1; -.
DR   PeptideAtlas; F8W7D1; -.
DR   PRIDE; F8W7D1; -.
DR   Ensembl; ENST00000388925; ENSP00000373577; ENSG00000160111.
DR   UCSC; uc060vcm.1; human.
DR   EuPathDB; HostDB:ENSG00000160111.12; -.
DR   HGNC; HGNC:23228; CPAMD8.
DR   OpenTargets; ENSG00000160111; -.
DR   eggNOG; ENOG410IMYE; Eukaryota.
DR   eggNOG; ENOG4111F6K; LUCA.
DR   GeneTree; ENSGT00940000162399; -.
DR   ChiTaRS; CPAMD8; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000160111; Expressed in 179 organ(s), highest expression level in prostate gland.
DR   ExpressionAtlas; F8W7D1; baseline and differential.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR002890; MG2.
DR   Pfam; PF01835; MG2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:F8W7D1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    503       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003379634.
FT   DOMAIN      130    221       MG2. {ECO:0000259|Pfam:PF01835}.
SQ   SEQUENCE   503 AA;  56064 MW;  F3EDF972B6605ABD CRC64;
     MSGALLWPLL PLLLLLLSAR DGVRAAQPQA PGYLIAAPSV FRAGVEEVIS VTIFNSPREV
     TVQAQLVAQG EPVVQSQGAI LDKGTIKLKV PTGLRGQALL KVWGRGWQAE EGPLFHNQTS
     VTVDGRGASV FIQTDKPVYR PQHRVLISIF TVSPNLRPVN EKLEAYILDP RGSRMIEWRH
     LKPFCCGITN MSFPLSDQPV LGEWFIFVEM QGHAYNKSFE VQKYVLPKFE LLIDPPRYIQ
     DLDACETGTV RARYTFGKPV AGALMINMTV NGVGYYSHEV GRPVLRTTKI LGSRDFDICV
     RDMIPADVPE HFRGRVSIWA MVTSVDGSQQ VAFDDSTPVQ RQLVDIRYSK DTRKQFKPGL
     AYVGKVELSY PDGSPAEGVT VQIKAELTPK DNIYTSEVVS QRGLVGFEIP SIPTSAQHVW
     LEVFQELEDY DVSDSFGVSR EDGPFWWAGL TAQRRRRSSV FPWPWGITKD SGFAFTVRRG
     NGTGGDDRPS EPEPPAGRWP LHR
//