ID   F8W775_HUMAN            Unreviewed;      1299 AA.
AC   F8W775;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 2.
DT   05-DEC-2018, entry version 53.
DE   SubName: Full=Neuronal cell adhesion molecule {ECO:0000313|Ensembl:ENSP00000368308};
GN   Name=NRCAM {ECO:0000313|Ensembl:ENSP00000368308};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000368308, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000368308, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000368308}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC005058; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC005683; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC007567; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF510970; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; F8W775; -.
DR   PeptideAtlas; F8W775; -.
DR   PRIDE; F8W775; -.
DR   Ensembl; ENST00000379022; ENSP00000368308; ENSG00000091129.
DR   UCSC; uc064hau.1; human.
DR   EuPathDB; HostDB:ENSG00000091129.19; -.
DR   HGNC; HGNC:7994; NRCAM.
DR   OpenTargets; ENSG00000091129; -.
DR   eggNOG; KOG3513; Eukaryota.
DR   eggNOG; ENOG410XSVG; LUCA.
DR   GeneTree; ENSGT00940000155419; -.
DR   ChiTaRS; NRCAM; human.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000091129; Expressed in 186 organ(s), highest expression level in middle temporal gyrus.
DR   ExpressionAtlas; F8W775; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   CDD; cd00063; FN3; 5.
DR   Gene3D; 2.60.40.10; -; 11.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR026966; Neurofascin/L1/NrCAM_C.
DR   Pfam; PF13882; Bravo_FIGEY; 1.
DR   Pfam; PF00041; fn3; 5.
DR   Pfam; PF07679; I-set; 2.
DR   SMART; SM00060; FN3; 5.
DR   SMART; SM00409; IG; 6.
DR   SMART; SM00408; IGc2; 6.
DR   SUPFAM; SSF48726; SSF48726; 6.
DR   SUPFAM; SSF49265; SSF49265; 3.
DR   PROSITE; PS50853; FN3; 5.
DR   PROSITE; PS50835; IG_LIKE; 6.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Immunoglobulin domain {ECO:0000256|SAAS:SAAS00653601};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:F8W775,
KW   ECO:0000213|PeptideAtlas:F8W775};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00923712};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25   1299       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003379633.
FT   TRANSMEM   1164   1185       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       41    129       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      136    230       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      262    351       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      356    443       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      449    536       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      540    627       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      644    739       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      741    838       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      843    945       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      949   1046       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN     1059   1151       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
SQ   SEQUENCE   1299 AA;  143318 MW;  DE3DB526B43DFF28 CRC64;
     MPKKKRLSAG RVPLILFLCQ MISALEVPLD PKLLEDLVQP PTITQQSPKD YIIDPRENIV
     IQCEAKGKPP PSFSWTRNGT HFDIDKDPLV TMKPGTGTLI INIMSEGKAE TYEGVYQCTA
     RNERGAAVSN NIVVRPSRSP LWTKEKLEPI TLQSGQSLVL PCRPPIGLPP PIIFWMDNSF
     QRLPQSERVS QGLNGDLYFS NVLPEDTRED YICYARFNHT QTIQQKQPIS VKVISVDELN
     DTIAANLSDT EFYGAKSSRE RPPTFLTPEG NASNKEELRG NVLSLECIAE GLPTPIIYWA
     KEDGMLPKNR TVYKNFEKTL QIIHVSEADS GNYQCIAKNA LGAIHHTISV RVKAAPYWIT
     APQNLVLSPG EDGTLICRAN GNPKPRISWL TNGVPIEIAP DDPSRKIDGD TIIFSNVQER
     SSAVYQCNAS NEYGYLLANA FVNVLAEPPR ILTPANTLYQ VIANRPALLD CAFFGSPLPT
     IEWFKGAKGS ALHEDIYVLH ENGTLEIPVA QKDSTGTYTC VARNKLGMAK NEVHLEIKDP
     TWIVKQPEYA VVQRGSMVSF ECKVKHDHTL SLTVLWLKDN RELPSDERFT VDKDHLVVAD
     VSDDDSGTYT CVANTTLDSV SASAVLSVVA PTPTPAPVYD VPNPPFDLEL TDQLDKSVQL
     SWTPGDDNNS PITRIHHEYE DAMHKPGLWH HQTEVSGTQT TAQLKLSPYV NYSFRVMAVN
     SIGKSLPSEA SEQYLTKASE PDKNPTAVEG LGSEPDNLVI TWKPLNGFES NGPGLQYKVS
     WRQKDGDDEW TSVVVANVSK YIVSGTPTFV PYLIKVQALN DMGFAPEPAV VMGHSGEDLP
     MVAPGNVRVN VVNSTLAEVH WDPVPLKSIR GHLQGYRIYY WKTQSSSKRN RRHIEKKILT
     FQGSKTHGML PGLEPFSHYT LNVRVVNGKG EGPASPDRVF NTPEGVPSAP SSLKIVNPTL
     DSLTLEWDPP SHPNGILTEY TLKYQPINST HELGPLVDLK IPANKTRWTL KNLNFSTRYK
     FYFYAQTSAG SGSQITEEAV TTVDEAGILP PDVGAGKVQA VNPRISNLTA AAAETYANIS
     WEYEGPEHVN FYVEYGVAGS KEEWRKEIVN GSRSFFGLKG LMPGTAYKVR VGAVGDSGFV
     SSEDVFETGP AMASRQVDIA TQGWFIGLMC AVALLILILL IVCFIRRNKG GKYPVKEKED
     AHADPEIQPM KEDDGTFGEY SDAEDHKPLK KGSRTPSDRT VKKEDSDDSL VDYGEGVNGQ
     FNEDGSFIGQ YSGKKEKEPA EGNESSEAPS PVNAMNSFV
//