ID   F8W703_HUMAN            Unreviewed;      1439 AA.
AC   F8W703;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   16-JAN-2019, entry version 59.
DE   SubName: Full=Roundabout homolog 2 {ECO:0000313|Ensembl:ENSP00000327536};
GN   Name=ROBO2 {ECO:0000313|Ensembl:ENSP00000327536};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000327536, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000327536, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000327536}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC016942; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC024256; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC026877; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC067717; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC117514; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC126467; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC130004; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC131154; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC876890; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; F8W703; -.
DR   EPD; F8W703; -.
DR   jPOST; F8W703; -.
DR   MaxQB; F8W703; -.
DR   PeptideAtlas; F8W703; -.
DR   PRIDE; F8W703; -.
DR   Ensembl; ENST00000332191; ENSP00000327536; ENSG00000185008.
DR   UCSC; uc062lpp.1; human.
DR   EuPathDB; HostDB:ENSG00000185008.17; -.
DR   HGNC; HGNC:10250; ROBO2.
DR   OpenTargets; ENSG00000185008; -.
DR   GeneTree; ENSGT00940000156324; -.
DR   OMA; QQEAGYD; -.
DR   PhylomeDB; F8W703; -.
DR   ChiTaRS; ROBO2; human.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000185008; Expressed in 148 organ(s), highest expression level in forebrain.
DR   ExpressionAtlas; F8W703; baseline and differential.
DR   GO; GO:0030673; C:axolemma; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007411; P:axon guidance; IEA:InterPro.
DR   GO; GO:0001822; P:kidney development; IEA:InterPro.
DR   GO; GO:0035385; P:Roundabout signaling pathway; IEA:InterPro.
DR   CDD; cd00063; FN3; 3.
DR   Gene3D; 2.60.40.10; -; 8.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013106; Ig_V-set.
DR   InterPro; IPR032985; Robo2.
DR   PANTHER; PTHR44096:SF2; PTHR44096:SF2; 3.
DR   Pfam; PF00041; fn3; 3.
DR   Pfam; PF07679; I-set; 2.
DR   SMART; SM00060; FN3; 3.
DR   SMART; SM00409; IG; 5.
DR   SMART; SM00408; IGc2; 5.
DR   SMART; SM00406; IGv; 3.
DR   SUPFAM; SSF48726; SSF48726; 5.
DR   SUPFAM; SSF49265; SSF49265; 2.
DR   PROSITE; PS50853; FN3; 3.
DR   PROSITE; PS50835; IG_LIKE; 5.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:F8W703,
KW   ECO:0000213|PeptideAtlas:F8W703};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00923712};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22   1439       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003385435.
FT   TRANSMEM    860    882       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       31    127       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      133    220       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      225    309       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      314    409       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      417    504       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      524    618       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      637    735       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      739    836       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
SQ   SEQUENCE   1439 AA;  157354 MW;  F62FEE49DF9D4F1E CRC64;
     MSLLMFTQLL LCGFLYVRVD GSRLRQEDFP PRIVEHPSDV IVSKGEPTTL NCKAEGRPTP
     TIEWYKDGER VETDKDDPRS HRMLLPSGSL FFLRIVHGRR SKPDEGSYVC VARNYLGEAV
     SRNASLEVAL LRDDFRQNPT DVVVAAGEPA ILECQPPRGH PEPTIYWKKD KVRIDDKEER
     ISIRGGKLMI SNTRKSDAGM YTCVGTNMVG ERDSDPAELT VFERPTFLRR PINQVVLEEE
     AVEFRCQVQG DPQPTVRWKK DDADLPRGRY DIKDDYTLRI KKTMSTDEGT YMCIAENRVG
     KMEASATLTV RAPPQFVVRP RDQIVAQGRT VTFPCETKGN PQPAVFWQKE GSQNLLFPNQ
     PQQPNSRCSV SPTGDLTITN IQRSDAGYYI CQALTVAGSI LAKAQLEVTD VLTDRPPPII
     LQGPANQTLA VDGTALLKCK ATGDPLPVIS WLKEGFTFPG RDPRATIQEQ GTLQIKNLRI
     SDTGTYTCVA TSSSGETSWS AVLDVTESGA TISKNYDLSD LPGPPSKPQV TDVTKNSVTL
     SWQPGTPGTL PASAYIIEAF SQSVSNSWQT VANHVKTTLY TVRGLRPNTI YLFMVRAINP
     QGLSDPSPMS DPVRTQDISP PAQGVDHRQV QKELGDVLVR LHNPVVLTPT TVQVTWTVDR
     QPQFIQGYRV MYRQTSGLQA TSSWQNLDAK VPTERSAVLV NLKKGVTYEI KVRPYFNEFQ
     GMDSESKTVR TTEEAPSAPP QSVTVLTVGS YNSTSISVSW DPPPPDHQNG IIQEYKIWCL
     GNETRFHINK TVDAAIRSVI IGGLFPGIQY RVEVAASTSA GVGVKSEPQP IIIGRRNEVV
     ITENNNSITE QITDVVKQPA FIAGIGGACW VILMGFSIWL YWRRKKRKGL SNYAVTFQRG
     DGGLMSNGSR PGLLNAGDPS YPWLADSWPA TSLPVNNSNS GPNEIGNFGR GDVLPPVPGQ
     GDKTATMLSD GAIYSSIDFT TKTSYNSSSQ ITQATPYATT QILHSNSIHE LAVDLPDPQW
     KSSIQQKTDL MGFGYSLPDQ NKGNNGGKGG KKKKNKNSSK PQKNNGSTWA NVPLPPPPVQ
     PLPGTELEHY AVEQQENGYD SDSWCPPLPV QTYLHQGLED ELEEDDDRVP TPPVRGVASS
     PAISFGQQST ATLTPSPREE MQPMLQAHLD ELTRAYQFDI AKQTWHIQSN NQPPQPPVPP
     LGYVSGALIS DLETDVADDD ADDEEEALEI PRPLRALDQT PGSSMDNLDS SVTGSMVNGW
     GSASDEDRNF SSHRSSVGSS SDGSIFASGS FAQALVAAAD KAGFRLDGTS LTRTGKAFTS
     SQRPRPTSPF STDSNTSAAL SQSQRPRPTK KHKGGRMDQQ PALPHRREGM TDEEALVPYS
     KPSFPSPGGH SSSGTASSKG STGPRKTEVL RAGHQRNASD LLDIGYMGSN SQGQFTGEL
//