ID   F8W6L1_HUMAN            Unreviewed;       286 AA.
AC   F8W6L1;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   13-FEB-2019, entry version 49.
DE   SubName: Full=Thrombopoietin {ECO:0000313|Ensembl:ENSP00000411704};
GN   Name=THPO {ECO:0000313|Ensembl:ENSP00000411704};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000411704, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000411704, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000411704}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC078797; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001276926.1; NM_001289997.1.
DR   RefSeq; NP_001276956.1; NM_001290027.1.
DR   UniGene; Hs.1166; -.
DR   UniGene; Hs.734657; -.
DR   ProteinModelPortal; F8W6L1; -.
DR   PeptideAtlas; F8W6L1; -.
DR   Ensembl; ENST00000421442; ENSP00000411704; ENSG00000090534.
DR   GeneID; 7066; -.
DR   UCSC; uc003fon.4; human.
DR   CTD; 7066; -.
DR   EuPathDB; HostDB:ENSG00000090534.17; -.
DR   HGNC; HGNC:11795; THPO.
DR   OpenTargets; ENSG00000090534; -.
DR   GeneTree; ENSGT00390000006294; -.
DR   OrthoDB; 906192at2759; -.
DR   ChiTaRS; THPO; human.
DR   GenomeRNAi; 7066; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000090534; Expressed in 85 organ(s), highest expression level in right lobe of liver.
DR   ExpressionAtlas; F8W6L1; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0005125; F:cytokine activity; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0008283; P:cell population proliferation; IEA:InterPro.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR019767; EPO/TPO_CS.
DR   InterPro; IPR001323; EPO_TPO.
DR   InterPro; IPR003978; Thrombopoeitin.
DR   PANTHER; PTHR10560; PTHR10560; 1.
DR   Pfam; PF00758; EPO_TPO; 1.
DR   PRINTS; PR01485; THROMBOPTN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00817; EPO_TPO; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    286       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003385432.
SQ   SEQUENCE   286 AA;  31544 MW;  477EAC4BE75442F6 CRC64;
     MELTELLLVV MLLLTARLTL SSPAPPACDL RVLSKLLRDS HVLHSRLSQC PEVHPLPTPV
     LLPAVDFSLG EWKTQMEETK AQDILGAVTL LLEGVMAARG QLGPTCLSSL LGQLSGQVRL
     LLGALQSLLG TQLPPQGRTT AHKDPNAIFL SFQHLLRGKD FWIVGDKLHC LSQNYWLWAS
     EVAAGIQSQD SWSAEPNLQV PGPNPRIPEQ DTRTLEWNSW TLSWTLTQDP RSPGHFLRNI
     RHRLPATQPP AWIFSFPNPS SYWTVYALPS STHLAHPCGP APPPAS
//