ID   F8W6J7_HUMAN            Unreviewed;        93 AA.
AC   F8W6J7;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   05-DEC-2018, entry version 47.
DE   SubName: Full=Hemojuvelin {ECO:0000313|Ensembl:ENSP00000411863};
DE   Flags: Fragment;
GN   Name=HJV {ECO:0000313|Ensembl:ENSP00000411863};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000411863, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000411863, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA   Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA   James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA   Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA   Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA   Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA   Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA   Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA   Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA   Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA   Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA   Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA   Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA   Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA   Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA   Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA   Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA   Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA   Porter K.M., Prigmore E.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000411863}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC239799; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC243547; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; F8W6J7; -.
DR   PeptideAtlas; F8W6J7; -.
DR   Ensembl; ENST00000421822; ENSP00000411863; ENSG00000168509.
DR   UCSC; uc057kco.1; human.
DR   EuPathDB; HostDB:ENSG00000168509.18; -.
DR   HGNC; HGNC:4887; HJV.
DR   OpenTargets; ENSG00000168509; -.
DR   eggNOG; ENOG410IFAH; Eukaryota.
DR   eggNOG; ENOG410ZT7E; LUCA.
DR   GeneTree; ENSGT00940000156174; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000168509; Expressed in 92 organ(s), highest expression level in quadriceps femoris.
DR   ExpressionAtlas; F8W6J7; baseline and differential.
DR   GO; GO:1990712; C:HFE-transferrin receptor complex; IEA:InterPro.
DR   GO; GO:0036122; F:BMP binding; IEA:InterPro.
DR   GO; GO:0015026; F:coreceptor activity; IEA:InterPro.
DR   GO; GO:0030509; P:BMP signaling pathway; IEA:InterPro.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:InterPro.
DR   InterPro; IPR033606; Hemojuvelin.
DR   InterPro; IPR040287; RGM.
DR   PANTHER; PTHR31428; PTHR31428; 1.
DR   PANTHER; PTHR31428:SF3; PTHR31428:SF3; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     35       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        36     93       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003379412.
FT   NON_TER      93     93       {ECO:0000313|Ensembl:ENSP00000411863}.
SQ   SEQUENCE   93 AA;  9269 MW;  66303C9D4CA2C295 CRC64;
     MGEPGQSPSP RSSHGSPPTL STLTLLLLLC GHAHSQCKIL RCNAEYVSST LSLRGGGSSG
     ALRGGGGGGR GGGVGSGGLC RALRSYALCT RRT
//