ID F8W148_HUMAN Unreviewed; 187 AA. AC F8W148; DT 21-SEP-2011, integrated into UniProtKB/TrEMBL. DT 21-SEP-2011, sequence version 1. DT 05-DEC-2018, entry version 54. DE SubName: Full=Carbonic anhydrase 6 {ECO:0000313|Ensembl:ENSP00000447108}; DE Flags: Fragment; GN Name=CA6 {ECO:0000313|Ensembl:ENSP00000447108}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000447108, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000447108, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C., RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K., RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., RA Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S., RA Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., RA James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., RA Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., RA Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., RA Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., RA Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J., RA Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., RA Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., RA Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., RA Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., RA Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., RA Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., RA Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., RA Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R., RA Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., RA Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R., RA Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P., RA Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D., RA Porter K.M., Prigmore E.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000447108} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01134}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL139415; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F8W148; -. DR SMR; F8W148; -. DR PeptideAtlas; F8W148; -. DR PRIDE; F8W148; -. DR Ensembl; ENST00000549778; ENSP00000447108; ENSG00000131686. DR UCSC; uc057bzy.1; human. DR EuPathDB; HostDB:ENSG00000131686.14; -. DR HGNC; HGNC:1380; CA6. DR OpenTargets; ENSG00000131686; -. DR GeneTree; ENSGT00940000160409; -. DR Proteomes; UP000005640; Chromosome 1. DR Bgee; ENSG00000131686; Expressed in 70 organ(s), highest expression level in parotid gland. DR ExpressionAtlas; F8W148; baseline and differential. DR GO; GO:0004089; F:carbonate dehydratase activity; IEA:InterPro. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0006730; P:one-carbon metabolic process; IEA:InterPro. DR Gene3D; 3.10.200.10; -; 1. DR InterPro; IPR001148; CA_dom. DR InterPro; IPR036398; CA_dom_sf. DR InterPro; IPR023561; Carbonic_anhydrase_a-class. DR InterPro; IPR018338; Carbonic_anhydrase_a-class_CS. DR InterPro; IPR018428; Carbonic_anhydrase_CA6. DR PANTHER; PTHR18952; PTHR18952; 2. DR PANTHER; PTHR18952:SF110; PTHR18952:SF110; 2. DR Pfam; PF00194; Carb_anhydrase; 2. DR SMART; SM01057; Carb_anhydrase; 1. DR SUPFAM; SSF51069; SSF51069; 1. DR PROSITE; PS00162; ALPHA_CA_1; 1. DR PROSITE; PS51144; ALPHA_CA_2; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Metal-binding {ECO:0000256|SAAS:SAAS00011910}; KW Proteomics identification {ECO:0000213|MaxQB:F8W148, KW ECO:0000213|PeptideAtlas:F8W148}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Zinc {ECO:0000256|SAAS:SAAS00011886}. FT SIGNAL 1 17 {ECO:0000256|SAM:SignalP}. FT CHAIN 18 187 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003379314. FT DOMAIN 1 187 Alpha-carbonic anhydrase. FT {ECO:0000259|PROSITE:PS51144}. FT NON_TER 187 187 {ECO:0000313|Ensembl:ENSP00000447108}. SQ SEQUENCE 187 AA; 21063 MW; AE9B3B42CE507DCF CRC64; MRALVLLLSL FLLGGQAQHV SDWTYSEGAL DEAHWPQHYP ACGGQRQSPI NLQRTKISLP STMRMTVADG TVYIAQQMHF HWGGASSEIS GSEHTVDGIR HVIEIHIVHY NSKYKSYDIA QDAPDGLAVL AAFVEVKNYP ENTYYSNFIS HLANIKYPGQ RTTLTGLDVQ DMLPRNLQHY YTYHGSL //