ID   F8VX10_HUMAN            Unreviewed;       675 AA.
AC   F8VX10;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   16-JAN-2019, entry version 58.
DE   SubName: Full=KAT8 regulatory NSL complex subunit 2 {ECO:0000313|Ensembl:ENSP00000449747};
GN   Name=KANSL2 {ECO:0000313|Ensembl:ENSP00000449747};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000449747, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000449747, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16541075; DOI=10.1038/nature04569;
RG   Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team;
RA   Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA   Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA   Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M.,
RA   Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D.,
RA   Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z.,
RA   Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H.,
RA   Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H.,
RA   Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V.,
RA   Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J., Santibanez J.,
RA   Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A.,
RA   Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M.,
RA   Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E.,
RA   Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA   Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA   Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M.,
RA   Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R.,
RA   Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J.,
RA   Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C.,
RA   Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M.,
RA   Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M.,
RA   Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P.,
RA   Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L.,
RA   Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E.,
RA   Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C.,
RA   Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F.,
RA   Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M.,
RA   Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S.,
RA   Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA   Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA   Perrin W., Pickens A., Primus E.L., Pu L.L., Puazo M., Quiles M.M.,
RA   Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA   Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA   Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D.,
RA   Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I.,
RA   Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T.,
RA   Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S.,
RA   Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D.,
RA   Kucherlapati R., Weinstock G., Gibbs R.A., null.;
RT   "The finished DNA sequence of human chromosome 12.";
RL   Nature 440:346-351(2006).
RN   [2] {ECO:0000213|PubMed:20068231}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA   Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA   Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA   Mann M.;
RT   "Quantitative phosphoproteomics reveals widespread full
RT   phosphorylation site occupancy during mitosis.";
RL   Sci. Signal. 3:ra3-RA3(2010).
RN   [3] {ECO:0000213|PubMed:21406692}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA   Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
RA   Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
RA   Blagoev B.;
RT   "System-wide temporal characterization of the proteome and
RT   phosphoproteome of human embryonic stem cell differentiation.";
RL   Sci. Signal. 4:rs3-RS3(2011).
RN   [4] {ECO:0000313|Ensembl:ENSP00000449747}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [5] {ECO:0000213|PubMed:23186163}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23186163;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [6] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [7] {ECO:0000213|PubMed:28112733}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=28112733;
RA   Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA   Nielsen M.L.;
RT   "Site-specific mapping of the human SUMO proteome reveals co-
RT   modification with phosphorylation.";
RL   Nat. Struct. Mol. Biol. 24:325-336(2017).
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DR   EMBL; AC079951; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455646; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; F8VX10; -.
DR   EPD; F8VX10; -.
DR   jPOST; F8VX10; -.
DR   MaxQB; F8VX10; -.
DR   PRIDE; F8VX10; -.
DR   Ensembl; ENST00000550347; ENSP00000449747; ENSG00000139620.
DR   UCSC; uc001rrz.4; human.
DR   EuPathDB; HostDB:ENSG00000139620.12; -.
DR   HGNC; HGNC:26024; KANSL2.
DR   OpenTargets; ENSG00000139620; -.
DR   eggNOG; ENOG410II1C; Eukaryota.
DR   eggNOG; ENOG4110KNV; LUCA.
DR   GeneTree; ENSGT00940000155808; -.
DR   OMA; LAKIKYC; -.
DR   ChiTaRS; KANSL2; human.
DR   Proteomes; UP000005640; Chromosome 12.
DR   Bgee; ENSG00000139620; Expressed in 90 organ(s), highest expression level in gastrocnemius.
DR   ExpressionAtlas; F8VX10; baseline and differential.
DR   GO; GO:0015629; C:actin cytoskeleton; IDA:HPA.
DR   GO; GO:0005829; C:cytosol; IDA:HPA.
DR   GO; GO:0000123; C:histone acetyltransferase complex; IEA:InterPro.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR   InterPro; IPR026316; NSL2.
DR   InterPro; IPR025927; Potential_DNA-bd.
DR   PANTHER; PTHR13453; PTHR13453; 1.
DR   Pfam; PF13891; zf-C3Hc3H; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:F8VX10,
KW   ECO:0000213|MaxQB:F8VX10, ECO:0000213|PeptideAtlas:F8VX10};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     26       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        27    675       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003379354.
FT   DOMAIN      211    274       zf-C3Hc3H. {ECO:0000259|Pfam:PF13891}.
FT   DOMAIN      490    547       zf-C3Hc3H. {ECO:0000259|Pfam:PF13891}.
SQ   SEQUENCE   675 AA;  74681 MW;  957098A6206ED548 CRC64;
     MAVLFPLSSC GWAAISLFLS AQSCYSASKQ CQSQSPSCRL PGARISGDWS RRTKWRSHRL
     PRPGPVVRSE AGRDKGGVRG GGVAAAWGWC CRFPSCCSCA SPEDTFSVVW FGVGPGMEGH
     AKGRQSHRCL WRLGEGGGDL RSVPYGDDFC MSFGNCPRDL CGAGIFGKGK GFLVFRLTPQ
     VLVMNRIRIH VLPTNRGRIT PVPRSQEPLS CAFTHRPCSH PRLEGQEFCI KHILEDKNAP
     FKQCSYISTK NGKRCPNAAP KPEKKDGVSF CAEHVRRNAL ALHAQMKKTN PGPVGETLLC
     QLSSYAKTEL GSQTPESSRS EASRILDEDS WSDGEQEPIT VDQTWRGDPD SEADSIDSDQ
     EDPLKHAGVY TAEEVALIMR EKLIRLQSLY IDQFKRLQHL LKEKKRRYLH NRKVEHEALG
     SSLLTGPEGL LAKERENLKR LKCLRRYRQR YGVEALLHRQ LKERRMLATD GAAQQAHTTR
     SSQRCLAFVD DVRCSNQSLP MTRHCLTHIC QDTNQVLFKC CQGSEEVPCN KPVPVSLSED
     PCCPLHFQLP PQMYKPEQVL SVPDDLEAGP MDLYLSAAEL QPTESLPLEF SDDLDVVGDG
     MQCPPSPLLF DPSLTLEDHL VKEIAEDPVD ILGQMQMAGD GCRSQGSRNS EKASAPLSQS
     GLATANGKPE PTSIS
//