ID   F8VWW8_HUMAN            Unreviewed;       407 AA.
AC   F8VWW8;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   16-JAN-2019, entry version 51.
DE   SubName: Full=Acid sphingomyelinase-like phosphodiesterase 3b {ECO:0000313|Ensembl:ENSP00000449450};
GN   Name=SMPDL3B {ECO:0000313|Ensembl:ENSP00000449450};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000449450, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000449450, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA   Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA   James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA   Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA   Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA   Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA   Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA   Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA   Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA   Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA   Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA   Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA   Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA   Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA   Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA   Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA   Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA   Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA   Porter K.M., Prigmore E.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000449450}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AL512288; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; F8VWW8; -.
DR   IntAct; F8VWW8; 1.
DR   EPD; F8VWW8; -.
DR   jPOST; F8VWW8; -.
DR   MaxQB; F8VWW8; -.
DR   PeptideAtlas; F8VWW8; -.
DR   PRIDE; F8VWW8; -.
DR   Ensembl; ENST00000549094; ENSP00000449450; ENSG00000130768.
DR   UCSC; uc010ofr.3; human.
DR   EuPathDB; HostDB:ENSG00000130768.14; -.
DR   HGNC; HGNC:21416; SMPDL3B.
DR   OpenTargets; ENSG00000130768; -.
DR   GeneTree; ENSGT00940000153816; -.
DR   ChiTaRS; SMPDL3B; human.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000130768; Expressed in 102 organ(s), highest expression level in mucosa of transverse colon.
DR   ExpressionAtlas; F8VWW8; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0004767; F:sphingomyelin phosphodiesterase activity; IEA:InterPro.
DR   GO; GO:0006685; P:sphingomyelin catabolic process; IEA:InterPro.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR017064; ASM-like_Pdiesterase_prd.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   PIRSF; PIRSF036767; ASM-like_PDE; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:F8VWW8,
KW   ECO:0000213|MaxQB:F8VWW8, ECO:0000213|PeptideAtlas:F8VWW8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    407       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003379288.
SQ   SEQUENCE   407 AA;  45315 MW;  FF8A02BBBB998AF8 CRC64;
     MRLLAWLIFL ANWGGARAEP GKFWHIADLH LDPDYKVSKD PFQVCPSAGS QPVPDAGPWG
     DYLCDSPWAL INSSIYAMKE IEPEPDFILW TGDDTPHVPD EKLGEAAVLE IVERLTKLIR
     EVFPGAFYCE KLPGPSGAGR IVVLNTNLYY TSNALTADMA DPGQQFQWLE DVLTDASKAG
     DMVYIVGHVP PGFFEKTQNK AWFREGFNEK YLKVVRKHHR VIAGQFFGHH HTDSFRMLYD
     DAGVPISAMF ITPGVTPWKT TLPGVVNGAN NPAIRVFEYD RATLSLKDMV TYFMNLSQAN
     AQGTPRWELE YQLTEAYGVP DASAHSMHTV LDRIAGDQST LQRYYVYNSV SYSAGVCDEA
     CSMQHVCAMR QVDIDAYTTC LYASGTTPVP QLPLLLMALL GLCTLVL
//