ID   F8VVB6_HUMAN            Unreviewed;       768 AA.
AC   F8VVB6;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   12-SEP-2018, entry version 58.
DE   SubName: Full=Protein kinase C-binding protein NELL2 {ECO:0000313|Ensembl:ENSP00000449332};
GN   Name=NELL2 {ECO:0000313|Ensembl:ENSP00000449332};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000449332, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000449332, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16541075; DOI=10.1038/nature04569;
RG   Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team;
RA   Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA   Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA   Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M.,
RA   Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D.,
RA   Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z.,
RA   Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H.,
RA   Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H.,
RA   Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V.,
RA   Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J., Santibanez J.,
RA   Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A.,
RA   Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M.,
RA   Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E.,
RA   Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA   Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA   Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M.,
RA   Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R.,
RA   Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J.,
RA   Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C.,
RA   Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M.,
RA   Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M.,
RA   Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P.,
RA   Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L.,
RA   Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E.,
RA   Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C.,
RA   Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F.,
RA   Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M.,
RA   Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S.,
RA   Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA   Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA   Perrin W., Pickens A., Primus E.L., Pu L.L., Puazo M., Quiles M.M.,
RA   Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA   Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA   Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D.,
RA   Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I.,
RA   Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T.,
RA   Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S.,
RA   Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D.,
RA   Kucherlapati R., Weinstock G., Gibbs R.A., null.;
RT   "The finished DNA sequence of human chromosome 12.";
RL   Nature 440:346-351(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000449332}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; AC018923; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC025253; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC079033; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC079825; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC090012; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455639; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; F8VVB6; -.
DR   PeptideAtlas; F8VVB6; -.
DR   PRIDE; F8VVB6; -.
DR   Ensembl; ENST00000551601; ENSP00000449332; ENSG00000184613.
DR   UCSC; uc009zkd.3; human.
DR   EuPathDB; HostDB:ENSG00000184613.10; -.
DR   HGNC; HGNC:7751; NELL2.
DR   OpenTargets; ENSG00000184613; -.
DR   GeneTree; ENSGT00810000125439; -.
DR   ChiTaRS; NELL2; human.
DR   Proteomes; UP000005640; Chromosome 12.
DR   Bgee; ENSG00000184613; Expressed in 204 organ(s), highest expression level in middle temporal gyrus.
DR   ExpressionAtlas; F8VVB6; baseline and differential.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR001007; VWF_dom.
DR   Pfam; PF07645; EGF_CA; 3.
DR   Pfam; PF02210; Laminin_G_2; 1.
DR   Pfam; PF00093; VWC; 2.
DR   SMART; SM00181; EGF; 5.
DR   SMART; SM00179; EGF_CA; 4.
DR   SMART; SM00282; LamG; 1.
DR   SMART; SM00210; TSPN; 1.
DR   SMART; SM00214; VWC; 3.
DR   SMART; SM00215; VWC_out; 2.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS00010; ASX_HYDROXYL; 2.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 3.
DR   PROSITE; PS50026; EGF_3; 5.
DR   PROSITE; PS01187; EGF_CA; 1.
DR   PROSITE; PS01208; VWFC_1; 2.
DR   PROSITE; PS50184; VWFC_2; 3.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00601599};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00032677};
KW   Proteomics identification {ECO:0000213|MaxQB:F8VVB6,
KW   ECO:0000213|PeptideAtlas:F8VVB6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00966518};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    768       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003385331.
FT   DOMAIN      271    330       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN      396    438       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      439    480       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      481    521       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      522    552       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      554    589       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      590    645       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN      650    708       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   COILED      240    267       {ECO:0000256|SAM:Coils}.
FT   DISULFID    524    534       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    542    551       {ECO:0000256|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   768 AA;  85922 MW;  74326169A137B9EE CRC64;
     METGLGAPLF KAWLLISVWG LGVDPSLQID VLTELELGES TTGVRQVPGL HNGTKAFLFQ
     DTPRSIKAST ATAEQFFQKL RNKHEFTILV TLKQTHLNSG VILSIHHLDH RYLELESSGH
     RNEVRLHYRS GSHRPHTEVF PYILADDKWH KLSLAISASH LILHIDCNKI YERVVEKPST
     DLPLGTTFWL GQRNNAHGYF KGIMQDVQLL VMPQGFIAQC PDLNRTCPTC NDFHGLVQKI
     MELQDILAKT SAKLSRAEQR MNRLDQCYCE RTCTMKGTTY REFESWIDGC KNCTCLNGTI
     QCETLICPNP DCPLKSALAY VDGKCCKECK SICQFQGRTY FEGERNTVYS SSGVCVLYEC
     KDQTMKLVES SGCPALDCPE SHQITLSHSC CKVCKGYDFC SERHNCMENS ICRNLNDRAV
     CSCRDGFRAL REDNAYCEDI DECAEGRHYC RENTMCVNTP GSFMCICKTG YIRIDDYSCT
     EHDECITNQH NCDENALCFN TVGGHNCVCK PGYTGNGTTC KAFCKDGCRN GGACIAANVC
     ACPQGFTGPS CETDIDECGT GRHSCANDTI CFNLDGGYDC RCPHGKNCTG DCIHDGKVKH
     NGQIWVLEND RCSVCSCQNG FVMCRRMVCD CENPTVDLFC CPECDPRLSS QCLHQNGETL
     YNSGDTWVQN CQQCRCLQGE VDCWPLPCPD VECEFSILPE NECCPRCVTD PCQADTIRND
     ITKTCLDEMN VVRFTGSSWI KHGTECTLCQ CKNGHICCSV DPQCLQEL
//