ID F8VSH2_HUMAN Unreviewed; 637 AA. AC F8VSH2; DT 21-SEP-2011, integrated into UniProtKB/TrEMBL. DT 21-SEP-2011, sequence version 1. DT 13-FEB-2019, entry version 57. DE SubName: Full=Protein O-mannosyl-transferase TMTC2 {ECO:0000313|Ensembl:ENSP00000448292}; GN Name=TMTC2 {ECO:0000313|Ensembl:ENSP00000448292}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000448292, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000448292, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16541075; DOI=10.1038/nature04569; RG Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team; RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., RA Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., RA Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., RA Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., RA Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., RA Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., RA Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., RA Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., RA Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., RA Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J., Santibanez J., RA Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., RA Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., RA Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., RA Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., RA Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., RA Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., RA Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., RA Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., RA Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., RA Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., RA Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., RA Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., RA Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., RA Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., RA Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., RA Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., RA Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., RA Perrin W., Pickens A., Primus E.L., Pu L.L., Puazo M., Quiles M.M., RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., RA Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., RA Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., RA Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., RA Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., RA Kucherlapati R., Weinstock G., Gibbs R.A., null.; RT "The finished DNA sequence of human chromosome 12."; RL Nature 440:346-351(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000448292} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC079595; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC090667; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC090680; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC091214; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC117375; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001307251.1; NM_001320322.1. DR UniGene; Hs.577775; -. DR ProteinModelPortal; F8VSH2; -. DR MaxQB; F8VSH2; -. DR PeptideAtlas; F8VSH2; -. DR PRIDE; F8VSH2; -. DR Ensembl; ENST00000548305; ENSP00000448292; ENSG00000179104. DR GeneID; 160335; -. DR UCSC; uc001szr.2; human. DR CTD; 160335; -. DR EuPathDB; HostDB:ENSG00000179104.8; -. DR HGNC; HGNC:25440; TMTC2. DR OpenTargets; ENSG00000179104; -. DR eggNOG; ENOG410IQRH; Eukaryota. DR eggNOG; ENOG410XP5Q; LUCA. DR GeneTree; ENSGT00940000156144; -. DR OrthoDB; 1320023at2759; -. DR ChiTaRS; TMTC2; human. DR GenomeRNAi; 160335; -. DR Proteomes; UP000005640; Chromosome 12. DR Bgee; ENSG00000179104; Expressed in 181 organ(s), highest expression level in stomach. DR ExpressionAtlas; F8VSH2; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR Gene3D; 1.25.40.10; -; 1. DR InterPro; IPR013618; DUF1736. DR InterPro; IPR013026; TPR-contain_dom. DR InterPro; IPR011990; TPR-like_helical_dom_sf. DR InterPro; IPR019734; TPR_repeat. DR Pfam; PF08409; DUF1736; 1. DR Pfam; PF13181; TPR_8; 1. DR SMART; SM00028; TPR; 3. DR SUPFAM; SSF48452; SSF48452; 1. DR PROSITE; PS50005; TPR; 3. DR PROSITE; PS50293; TPR_REGION; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|PeptideAtlas:F8VSH2}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 637 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003379333. FT TRANSMEM 85 106 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 136 156 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 168 185 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 191 209 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 221 245 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 311 328 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 393 417 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 423 443 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 450 468 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 493 594 TPR_REGION. FT {ECO:0000259|PROSITE:PS50293}. FT REPEAT 493 526 TPR. {ECO:0000256|PROSITE- FT ProRule:PRU00339}. FT REPEAT 527 560 TPR. {ECO:0000256|PROSITE- FT ProRule:PRU00339}. FT REPEAT 561 594 TPR. {ECO:0000256|PROSITE- FT ProRule:PRU00339}. SQ SEQUENCE 637 AA; 71424 MW; CF2579B37123417C CRC64; MIAELVSSAL GLALYLNTLS ADFCYDDSRA IKTNQDLLPE TPWTHIFYND FWGTLLTHSG SHKSYRPLCT LSFRLNHAIG GLNPWSYHLV NVLLHAAVTG LFTSFSKILL GDGYWTFMAG LMFASHPIHT EAVAGIVGRA DVGASLFFLL SLLCYIKHCS TRGYSARTWG WFLGSGLCAG CSMLWKEQGV TVLAVSAVYD VFVFHRLKIK QILPTIYKRK NLSLFLSISL LIFWGSSLLG ARLYWMGNKP PSFSNSDNPA ADSDSLLTRT LTFFYLPTKN LWLLLCPDTL SFDWSMDAVP LLKTVCDWRN LHTVAFYTGL LLLAYYGLKS PSVDRECNGK TVTNGKQNAN GHSCLSDVEY QNSETKSSFA SKVENGIKND VSQRTQLPST ENIVVLSLSL LIIPFVPATN LFFYVGFVIA ERVLYIPSMG FCLLITVGAR ALYVKVQKRF LKSLIFYATA TLIVFYGLKT AIRNGDWQNE EMLYRSGIKV NPAKAWGNLG NVLKSQSKIS EAESAYRNAL YYRSNMADML YNLGLLLQEN SRFAEALHYY KLAIGSRPTL ASAYLNTGII LMNQGRTEEA RRTFLKCSEI PDENLKDPHA HKSSVTSCLY NLGKLYHEQG HYEVWPMPLC PFPSPLF //