ID F8VNR3_HUMAN Unreviewed; 166 AA. AC F8VNR3; DT 21-SEP-2011, integrated into UniProtKB/TrEMBL. DT 21-SEP-2011, sequence version 1. DT 13-FEB-2019, entry version 52. DE SubName: Full=Protransforming growth factor alpha {ECO:0000313|Ensembl:ENSP00000404131}; GN Name=TGFA {ECO:0000313|Ensembl:ENSP00000404131}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000404131, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000404131, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., RA Waterston R.H., Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 RT and 4."; RL Nature 434:724-731(2005). RN [2] {ECO:0000313|Ensembl:ENSP00000404131} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC005234; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC017084; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001295087.1; NM_001308158.1. DR UniGene; Hs.170009; -. DR UniGene; Hs.628298; -. DR ProteinModelPortal; F8VNR3; -. DR jPOST; F8VNR3; -. DR Ensembl; ENST00000444975; ENSP00000404131; ENSG00000163235. DR GeneID; 7039; -. DR UCSC; uc010fdq.4; human. DR CTD; 7039; -. DR EuPathDB; HostDB:ENSG00000163235.15; -. DR HGNC; HGNC:11765; TGFA. DR OpenTargets; ENSG00000163235; -. DR GeneTree; ENSGT00940000160058; -. DR OrthoDB; 1401257at2759; -. DR PhylomeDB; F8VNR3; -. DR ChiTaRS; TGFA; human. DR GenomeRNAi; 7039; -. DR Proteomes; UP000005640; Chromosome 2. DR Bgee; ENSG00000163235; Expressed in 192 organ(s), highest expression level in pigmented layer of retina. DR ExpressionAtlas; F8VNR3; baseline and differential. DR GO; GO:0005615; C:extracellular space; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005634; C:nucleus; IEA:Ensembl. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0005154; F:epidermal growth factor receptor binding; IEA:Ensembl. DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl. DR GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:Ensembl. DR GO; GO:0072574; P:hepatocyte proliferation; IEA:Ensembl. DR GO; GO:0060749; P:mammary gland alveolus development; IEA:Ensembl. DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl. DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl. DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl. DR GO; GO:0042493; P:response to drug; IEA:Ensembl. DR GO; GO:0042060; P:wound healing; IEA:Ensembl. DR InterPro; IPR013032; EGF-like_CS. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR015497; EGF_rcpt_ligand. DR PANTHER; PTHR10740; PTHR10740; 1. DR PROSITE; PS00022; EGF_1; 1. DR PROSITE; PS01186; EGF_2; 1. DR PROSITE; PS50026; EGF_3; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076}; KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:F8VNR3, KW ECO:0000213|PeptideAtlas:F8VNR3}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 166 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003379224. FT TRANSMEM 105 127 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 49 89 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DISULFID 79 88 {ECO:0000256|PROSITE-ProRule:PRU00076}. SQ SEQUENCE 166 AA; 17790 MW; 5557180147111D21 CRC64; MFKIGRGALD LFSELLSFGG IVLAACQALE NSTSPLSADP PVAAAVVSHF NDCPDSHTQF CFHGTCRFLV QEDKPACVCH SGYVGARCEH ADLLAVVAAS QKKQAITALV VVSIVALAVL IITCVLIHCC QVRKHCEWCR ALICRHEKPS ALLKGRTACC HSETVV //