ID   F6UFK6_HUMAN            Unreviewed;       278 AA.
AC   F6UFK6;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   16-JAN-2019, entry version 54.
DE   SubName: Full=T-cell differentiation antigen CD6 {ECO:0000313|Ensembl:ENSP00000440055};
DE   Flags: Fragment;
GN   Name=CD6 {ECO:0000313|Ensembl:ENSP00000440055};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000440055, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000440055, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000440055}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}.
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DR   EMBL; AP003721; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455397; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; F6UFK6; -.
DR   jPOST; F6UFK6; -.
DR   PeptideAtlas; F6UFK6; -.
DR   PRIDE; F6UFK6; -.
DR   Ensembl; ENST00000542157; ENSP00000440055; ENSG00000013725.
DR   UCSC; uc058bxd.1; human.
DR   EuPathDB; HostDB:ENSG00000013725.14; -.
DR   HGNC; HGNC:1691; CD6.
DR   OpenTargets; ENSG00000013725; -.
DR   eggNOG; ENOG410IK9E; Eukaryota.
DR   eggNOG; ENOG410YC2B; LUCA.
DR   GeneTree; ENSGT00940000161029; -.
DR   ChiTaRS; CD6; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000013725; Expressed in 185 organ(s), highest expression level in lymph node.
DR   ExpressionAtlas; F6UFK6; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR   Gene3D; 3.10.250.10; -; 2.
DR   InterPro; IPR001190; SRCR.
DR   InterPro; IPR017448; SRCR-like_dom.
DR   InterPro; IPR036772; SRCR-like_dom_sf.
DR   Pfam; PF00530; SRCR; 2.
DR   PRINTS; PR00258; SPERACTRCPTR.
DR   SMART; SM00202; SR; 2.
DR   SUPFAM; SSF56487; SSF56487; 2.
DR   PROSITE; PS00420; SRCR_1; 1.
DR   PROSITE; PS50287; SRCR_2; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00196,
KW   ECO:0000256|SAAS:SAAS00873970};
KW   Proteomics identification {ECO:0000213|MaxQB:F6UFK6,
KW   ECO:0000213|PeptideAtlas:F6UFK6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18    278       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003343943.
FT   DOMAIN       45    156       SRCR. {ECO:0000259|PROSITE:PS50287}.
FT   DOMAIN      161    260       SRCR. {ECO:0000259|PROSITE:PS50287}.
FT   DISULFID    230    240       {ECO:0000256|PROSITE-ProRule:PRU00196}.
FT   NON_TER     278    278       {ECO:0000313|Ensembl:ENSP00000440055}.
SQ   SEQUENCE   278 AA;  29193 MW;  C88B28B75164C7E7 CRC64;
     MWLFFGITGL LTAALSGHPS PAPPDQLNTS SAESELWEPG ERLPVRLTNG SSSCSGTVEV
     RLEASWEPAC GALWDSRAAE AVCRALGCGG AEAASQLAPP TPELPPPPAA GNTSVAANAT
     LAGAPALLCS GAEWRLCEVV EHACRSDGRR ARVTCAENRA LRLVDGGGAC AGRVEMLEHG
     EWGSVCDDTW DLEDAHVVCR QLGCGWAVQA LPGLHFTPGR GPIHRDQVNC SGAEAYLWDC
     PGLPGQHYCG HKEDAGAVCS ESSVTVKIEN KESRELML
//