ID   F6U495_HUMAN            Unreviewed;       302 AA.
AC   F6U495;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   13-FEB-2019, entry version 61.
DE   SubName: Full=Fibrillin-1 {ECO:0000313|Ensembl:ENSP00000440294};
GN   Name=FBN1 {ECO:0000313|Ensembl:ENSP00000440294};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000440294, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000440294, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
RA   Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
RA   Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
RA   Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
RA   Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
RA   Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K.,
RA   Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
RA   Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human
RT   chromosome 15.";
RL   Nature 440:671-675(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000440294}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; AC022467; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC084757; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC084758; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF459685; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; F6U495; -.
DR   EPD; F6U495; -.
DR   jPOST; F6U495; -.
DR   MaxQB; F6U495; -.
DR   PeptideAtlas; F6U495; -.
DR   PRIDE; F6U495; -.
DR   Ensembl; ENST00000537463; ENSP00000440294; ENSG00000166147.
DR   UCSC; uc059iym.1; human.
DR   EuPathDB; HostDB:ENSG00000166147.13; -.
DR   HGNC; HGNC:3603; FBN1.
DR   OpenTargets; ENSG00000166147; -.
DR   eggNOG; ENOG410IR7H; Eukaryota.
DR   eggNOG; ENOG410XSTY; LUCA.
DR   GeneTree; ENSGT00940000155011; -.
DR   ChiTaRS; FBN1; human.
DR   Proteomes; UP000005640; Chromosome 15.
DR   Bgee; ENSG00000166147; Expressed in 229 organ(s), highest expression level in adipose tissue of abdominal region.
DR   ExpressionAtlas; F6U495; baseline and differential.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005201; F:extracellular matrix structural constituent; IEA:InterPro.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR011398; FBN.
DR   InterPro; IPR040872; Fibrillin_U_N.
DR   InterPro; IPR017878; TB_dom.
DR   PANTHER; PTHR24039; PTHR24039; 1.
DR   Pfam; PF18193; Fibrillin_U_N; 1.
DR   SMART; SM00181; EGF; 3.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 1.
DR   PROSITE; PS51364; TB; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Proteomics identification {ECO:0000213|MaxQB:F6U495,
KW   ECO:0000213|PeptideAtlas:F6U495};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     27       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        28    302       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003347586.
FT   DOMAIN      146    178       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      184    212       TB. {ECO:0000259|PROSITE:PS51364}.
FT   DISULFID    150    160       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    168    177       {ECO:0000256|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   302 AA;  32096 MW;  96399F009F385706 CRC64;
     MRRGRLLEIA LGFTVLLASY TSHGADANLE AGNVKETRAS RAKRRGGGGH DALKGPNVCG
     SRYNAYCCPG WKTLPGGNQC IVPICRHSCG DGFCSRPNMC TCPSGQIAPS CGSRSIQHCN
     IRCMNGGSCS DDHCLCQKGY IGTHCGQPVC ESGCLNGGRC VAPNRCACTY GFTGPQCERD
     YRTGPCFTVI SNQMCQGQLS GIVCTKTLCC ATTSMNVKLE HTTVANMLYV PIQQEASNVA
     AVPGGLEMAL SALIWTNVPM EPICAASMQT ARIPWDLTAV CARKDTQVMA SLVQTLMSAL
     RT
//