ID   F6SYF8_HUMAN            Unreviewed;       364 AA.
AC   F6SYF8;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   16-JAN-2019, entry version 55.
DE   SubName: Full=Dickkopf-related protein 3 {ECO:0000313|Ensembl:ENSP00000433112};
GN   Name=DKK3 {ECO:0000313|Ensembl:ENSP00000433112};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000433112, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000433112, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000433112}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC124276; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001317149.1; NM_001330220.1.
DR   RefSeq; XP_016873043.1; XM_017017554.1.
DR   RefSeq; XP_016873044.1; XM_017017555.1.
DR   UniGene; Hs.292156; -.
DR   UniGene; Hs.731954; -.
DR   ProteinModelPortal; F6SYF8; -.
DR   SMR; F6SYF8; -.
DR   EPD; F6SYF8; -.
DR   jPOST; F6SYF8; -.
DR   MaxQB; F6SYF8; -.
DR   PeptideAtlas; F6SYF8; -.
DR   PRIDE; F6SYF8; -.
DR   Ensembl; ENST00000525493; ENSP00000433112; ENSG00000050165.
DR   GeneID; 27122; -.
DR   UCSC; uc010rcg.1; human.
DR   CTD; 27122; -.
DR   EuPathDB; HostDB:ENSG00000050165.17; -.
DR   HGNC; HGNC:2893; DKK3.
DR   OpenTargets; ENSG00000050165; -.
DR   eggNOG; ENOG410IRWK; Eukaryota.
DR   eggNOG; ENOG4111WWP; LUCA.
DR   GeneTree; ENSGT00390000000221; -.
DR   OMA; GNGTICD; -.
DR   OrthoDB; 1139517at2759; -.
DR   PhylomeDB; F6SYF8; -.
DR   ChiTaRS; DKK3; human.
DR   GenomeRNAi; 27122; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000050165; Expressed in 230 organ(s), highest expression level in primary visual cortex.
DR   ExpressionAtlas; F6SYF8; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0007275; P:multicellular organism development; IEA:InterPro.
DR   GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IEA:InterPro.
DR   InterPro; IPR006796; Dickkopf_N.
DR   InterPro; IPR039863; DKK-like.
DR   PANTHER; PTHR12113; PTHR12113; 1.
DR   Pfam; PF04706; Dickkopf_N; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:F6SYF8,
KW   ECO:0000213|PeptideAtlas:F6SYF8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     16       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        17    364       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003342009.
FT   DOMAIN      146    196       Dickkopf_N. {ECO:0000259|Pfam:PF04706}.
FT   COILED       40     78       {ECO:0000256|SAM:Coils}.
FT   COILED      328    348       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   364 AA;  39950 MW;  F33FD4CC05CD821E CRC64;
     MQRLGATLLC LLLAAAVPTA PAPAPTATSA PVKPGPALSY PQEEATLNEM FREVEELMED
     TQHKLRSAVE EMEAEEAAAK ASSEVNLANL PPSYHNETNT DTKVGNNTIH VHREIHKITN
     NQTGQMVFSE TVITSVGDEE GRRSHECIID EDCGPSMYCQ FASFQYTCQP CRGQRMLCTR
     DSECCGDQLC VWGHCTKMAT RGSNGTICDN QRDCQPGLCC AFQRGLLFPV CTPLPVEGEL
     CHDPASRLLD LITWELEPDG ALDRCPCASG LLCQPHRLPR LEPGFVPSLP SHSLVYVCKP
     TFVGSRDQDG EILLPREVPD EYEVGSFMEE VRQELEDLER SLTEEMALRE PAAAAAALLG
     GEEI
//