ID   F5H8L4_HUMAN            Unreviewed;       829 AA.
AC   F5H8L4;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   16-JAN-2019, entry version 45.
DE   SubName: Full=SID1 transmembrane family member 2 {ECO:0000313|Ensembl:ENSP00000399635};
GN   Name=SIDT2 {ECO:0000313|Ensembl:ENSP00000399635};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000399635, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000213|PubMed:17081983}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA   Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,
RA   Mann M.;
RT   "Global, in vivo, and site-specific phosphorylation dynamics in
RT   signaling networks.";
RL   Cell 127:635-648(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000399635, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [3] {ECO:0000213|PubMed:18669648}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [4] {ECO:0000313|Ensembl:ENSP00000399635}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AP005018; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; F5H8L4; -.
DR   EPD; F5H8L4; -.
DR   jPOST; F5H8L4; -.
DR   MaxQB; F5H8L4; -.
DR   PeptideAtlas; F5H8L4; -.
DR   PRIDE; F5H8L4; -.
DR   Ensembl; ENST00000431081; ENSP00000399635; ENSG00000149577.
DR   UCSC; uc001pqi.1; human.
DR   EuPathDB; HostDB:ENSG00000149577.15; -.
DR   HGNC; HGNC:24272; SIDT2.
DR   OpenTargets; ENSG00000149577; -.
DR   eggNOG; ENOG410IF6Z; Eukaryota.
DR   eggNOG; ENOG410XPBN; LUCA.
DR   GeneTree; ENSGT00390000010091; -.
DR   ChiTaRS; SIDT2; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000149577; Expressed in 227 organ(s), highest expression level in endothelial cell.
DR   ExpressionAtlas; F5H8L4; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0051033; F:RNA transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0033227; P:dsRNA transport; IEA:InterPro.
DR   InterPro; IPR025958; SID1_TM_fam.
DR   PANTHER; PTHR12185; PTHR12185; 1.
DR   Pfam; PF13965; SID-1_RNA_chan; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:F5H8L4,
KW   ECO:0000213|PeptideAtlas:F5H8L4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    829       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003324770.
FT   TRANSMEM    292    317       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    446    466       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    500    518       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    546    567       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    604    623       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    629    651       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    711    732       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    744    764       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    795    814       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   829 AA;  94066 MW;  B3411B29333A70A9 CRC64;
     MFALGLPFLV LLVASVESHL GVLGPKNVSQ KDAEFERTYV DEVNSELVNI YTFNHTVTRN
     RTEGVRVSVN VLNKQKGAPL LFVVRQKEAV VSFQVPLILR GMFQRKYLYQ KVERTLCQPP
     TKNESEIQFF YVDVSTLSPV NTTYQLRVSR MDDFVLRTGE QFSFNTTAAQ PQYFKYEFPE
     GVDSVIVKVT SNKAFPCSVI SIQDVLCPVY DLDNNVAFIG MYQTMTKKAA ITVQRKDFPS
     NSFYVVVVVK TEDQACGGSL PFYPFAEDEP VDQGHRQKTL SVLVSQAVTS EAYVSGMLFC
     LGIFLSFYLL TVLLACWENW RQKKKTLLVA IDRACPESAS LLGHPRVLAD SFPGSSPYEG
     YNYGSFENVS GSTDGLVDSA GTGDLSYGYQ GTRPRVDSMS SVEEDDYDTL TDIDSDKNVI
     RTKQYLYVAD LARKDKRVLR KKYQIYFWNI ATIAVFYALP VVQLVITYQT VVNVTGNQDI
     CYYNFLCAHP LGNLSAFNNI LSNLGYILLG LLFLLIILQR EINHNRALLR NDLCALECGI
     PKHFGLFYAM GTALMMEGLL SACYHVCPNY TNFQFDTSFM YMIAGLCMLK LYQKRHPDIN
     ASAYSAYACL AIVIFFSVLG VVFGKGNTAF WIVFSIIHII ATLLLSTQLY YMGRWKLDSG
     IFRRILHVLY TDCIRQCSGP LYVDRMVLLV MGNVINWSLA AYGLIMRPND FASYLLAIGI
     CNLLLYFAFY IIMKLRSGER IKLIPLLCIV CTSVVWGFAL FFFFQGLSTW QKTPAESREH
     NRDCILLDFF DDHDIWHFLS SIAMFGSFLV LLTLDDDLDT VQRDKIYVF
//