ID   F5H851_HUMAN            Unreviewed;      1678 AA.
AC   F5H851;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 2.
DT   05-DEC-2018, entry version 64.
DE   SubName: Full=Collagen alpha-6(IV) chain {ECO:0000313|Ensembl:ENSP00000443707};
GN   Name=COL4A6 {ECO:0000313|Ensembl:ENSP00000443707};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000443707, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000443707, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A.,
RA   Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G.,
RA   Jones M.C., Hurles M.E., Andrews T.D., Scott C.E., Searle S.,
RA   Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R.,
RA   Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L.,
RA   Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A.,
RA   Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S.,
RA   Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R.,
RA   Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M.,
RA   Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N.,
RA   Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D.,
RA   Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W.,
RA   Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C.,
RA   Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C.,
RA   Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J.,
RA   Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S.,
RA   Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I.,
RA   Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L.,
RA   Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P.,
RA   Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S.,
RA   Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A.,
RA   Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J.,
RA   Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J.,
RA   Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S.,
RA   de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z.,
RA   Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C.,
RA   Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W.,
RA   Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T.,
RA   Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I.,
RA   Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N.,
RA   Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J.,
RA   Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E.,
RA   Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S.,
RA   Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T.,
RA   Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S.,
RA   Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L.,
RA   Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A.,
RA   Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L.,
RA   Williams G., Williams L., Williamson A., Williamson H., Wilming L.,
RA   Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H.,
RA   Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A.,
RA   Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A.,
RA   Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T.,
RA   Gibbs R.A., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000443707}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AL031177; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL034369; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL109943; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL136080; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; F5H851; -.
DR   MaxQB; F5H851; -.
DR   PRIDE; F5H851; -.
DR   Ensembl; ENST00000545689; ENSP00000443707; ENSG00000197565.
DR   UCSC; uc065aqf.1; human.
DR   EuPathDB; HostDB:ENSG00000197565.15; -.
DR   HGNC; HGNC:2208; COL4A6.
DR   OpenTargets; ENSG00000197565; -.
DR   eggNOG; KOG3544; Eukaryota.
DR   eggNOG; ENOG410YAVF; LUCA.
DR   GeneTree; ENSGT00940000153991; -.
DR   ChiTaRS; COL4A6; human.
DR   Proteomes; UP000005640; Chromosome X.
DR   Bgee; ENSG00000197565; Expressed in 152 organ(s), highest expression level in esophagus.
DR   ExpressionAtlas; F5H851; baseline and differential.
DR   GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR   GO; GO:0005201; F:extracellular matrix structural constituent; IEA:InterPro.
DR   Gene3D; 2.170.240.10; -; 1.
DR   InterPro; IPR008160; Collagen.
DR   InterPro; IPR001442; Collagen_IV_NC.
DR   InterPro; IPR036954; Collagen_IV_NC_sf.
DR   InterPro; IPR016187; CTDL_fold.
DR   Pfam; PF01413; C4; 2.
DR   Pfam; PF01391; Collagen; 20.
DR   SMART; SM00111; C4; 2.
DR   SUPFAM; SSF56436; SSF56436; 2.
DR   PROSITE; PS51403; NC1_IV; 1.
PE   1: Evidence at protein level;
KW   Collagen {ECO:0000256|SAAS:SAAS00762088};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS01066595};
KW   Proteomics identification {ECO:0000213|MaxQB:F5H851,
KW   ECO:0000213|PeptideAtlas:F5H851};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22   1678       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003327292.
FT   DOMAIN     1454   1678       Collagen IV NC1.
FT                                {ECO:0000259|PROSITE:PS51403}.
SQ   SEQUENCE   1678 AA;  162497 MW;  936C2CC438AFFA96 CRC64;
     MHPGLWLLLV TLCLTEELAA AGEKSYGKPC GGQDCSGSCQ CFPEKGARGR PGPIGIQGPT
     GPQGFTGSTG LSGLKGERGF PGLLGPYGPK GDKGPMGVPG FLGINGIPGH PGQPGPRGPP
     GLDGCNGTQG AVGFPGPDGY PGLLGPPGLP GQKGSKGDPV LAPGSFKGMK GDPGLPGLDG
     ITGPQGAPGF PGAVGPAGPP GLQGPPGPPG PLGPDGNMGL GFQGEKGVKG DVGLPGPAGP
     PPSTGELEFM GFPKGKKGSK GEPGPKGFPG ISGPPGFPGL GTTGEKGEKG EKGIPGLPGP
     RGPMGSEGVQ GPPGQQGKKG TLGFPGLNGF QGIEGQKGDI GLPGPDVFID IDGAVISGNP
     GDPGVPGLPG LKGDEGIQGL RGPSGVPGLP ALSGVPGALG PQGFPGLKGD QGNPGRTTIG
     AAGLPGRDGL PGPPGPPGPP SPEFETETLH NKESGFPGLR GEQGPKGNLG LKGIKGDSGF
     CACDGGVPNT GPPGEPGPPG PWGLIGLPGL KGARGDRGSG GAQGPAGAPG LVGPLGPSGP
     KGKKGEPILS TIQGMPGDRG DSGSQGFRGV IGEPGKDGVP GLPGLPGLPG DGGQGFPGEK
     GLPGLPGEKG HPGPPGLPGN GLPGLPGPRG LPGDKGKDGL PGQQGLPGSK GITLPCIIPG
     SYGPSGFPGT PGFPGPKGSR GLPGTPGQPG SSGSKGEPGS PGLVHLPELP GFPGPRGEKG
     LPGFPGLPGK DGLPGMIGSP GLPGSKGATG DIFGAENGAP GEQGLQGLTG HKGFLGDSGL
     PGLKGVHGKP GLLGPKGERG SPGTPGQVGQ PGTPGSSGPY GIKGKSGLPG APGFPGISGH
     PGKKGTRGKK GPPGSIVKKG LPGLKGLPGN PGLVGLKGSP GSPGVAGLPA LSGPKGEKGS
     VGFVGFPGIP GLPGIPGTRG LKGIPGSTGK MGPSGRAGTP GEKGDRGNPG PVGIPSPRRP
     MSNLWLKGDK GSQGSAGSNG FPGPRGDKGE AGRPGPPGLP GAPGLPGIIK GVSGKPGPPG
     FMGIRGLPGL KGSSGITGFP GMPGESGSQG IRGSPGLPGA SGLPGLKGDN GQTVEISGSP
     GPKGQPGESG FKGTKGRDGL IGNIGFPGNK GEDGKVGVSG DVGLPGAPGF PGVAGMRGEP
     GLPGSSGHQG AIGPLGSPGL IGPKGFPGFP GLHGLNGLPG TKGTHGTPGP SITGVPGPAG
     LPGPKGEKGY PGIGIGAPGK PGLRGQKGDR GFPGLQGPAG LPGAPGISLP SLIAGQPGDP
     GRPGLDGERG RPGPAGPPGP PGPSSNQGDT GDPGFPGIPG FSGLPGELGL KGMRGEPGFM
     GTPGKVGPPG DPGFPGMKGK AGPRGSSGLQ GDPGQTPTAE AVQVPPGPLG LPGIDGIPGL
     TGDPGAQGPV GLQGSKGLPG IPGKDGPSGL PGPPGALGDP GLPGLQGPPG FEGAPGQQGP
     FGMPGMPGQS MRVGYTLVKH SQSEQVPPCP IGMSQLWVGY SLLFVEGQEK AHNQDLGFAG
     SCLPRFSTMP FIYCNINEVC HYARRNDKSY WLSTTAPIPM MPVSQTQIPQ YISRCSVCEA
     PSQAIAVHSQ DITIPQCPLG WRSLWIGYSF LMHTAAGAEG GGQSLVSPGS CLEDFRATPF
     IECSGARGTC HYFANKYSFW LTTVEERQQF GELPVSETLK AGQLHTRVSR CQVCMKSL
//