ID F5H7V9_HUMAN Unreviewed; 1838 AA. AC F5H7V9; DT 28-JUN-2011, integrated into UniProtKB/TrEMBL. DT 28-JUN-2011, sequence version 1. DT 13-FEB-2019, entry version 73. DE SubName: Full=Tenascin {ECO:0000313|Ensembl:ENSP00000442242}; GN Name=TNC {ECO:0000313|Ensembl:ENSP00000442242}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000442242, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000442242, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164053; DOI=10.1038/nature02465; RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., RA Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., RA Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., RA Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R., RA Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., RA Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., RA Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., RA Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., RA Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., RA Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., RA Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., RA Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., RA Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., RA McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., RA Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., RA Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., RA Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., RA Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., RA Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., RA Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., RA Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R., RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., RA Rogers J., Dunham I.; RT "DNA sequence and analysis of human chromosome 9."; RL Nature 429:369-374(2004). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000313|Ensembl:ENSP00000442242} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [4] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [5] {ECO:0000313|Ensembl:ENSP00000438152} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2014) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL162425; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR SwissPalm; F5H7V9; -. DR EPD; F5H7V9; -. DR jPOST; F5H7V9; -. DR MaxQB; F5H7V9; -. DR PRIDE; F5H7V9; -. DR Ensembl; ENST00000535648; ENSP00000438152; ENSG00000041982. DR Ensembl; ENST00000542877; ENSP00000442242; ENSG00000041982. DR UCSC; uc022bmj.2; human. DR EuPathDB; HostDB:ENSG00000041982.15; -. DR HGNC; HGNC:5318; TNC. DR OpenTargets; ENSG00000041982; -. DR GeneTree; ENSGT00940000155188; -. DR OrthoDB; 18592at2759; -. DR ChiTaRS; TNC; human. DR Proteomes; UP000005640; Chromosome 9. DR Bgee; ENSG00000041982; Expressed in 213 organ(s), highest expression level in layer of synovial tissue. DR ExpressionAtlas; F5H7V9; baseline and differential. DR GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro. DR GO; GO:0007155; P:cell adhesion; IEA:InterPro. DR GO; GO:0042127; P:regulation of cell population proliferation; IEA:InterPro. DR CDD; cd00063; FN3; 11. DR CDD; cd00087; FReD; 1. DR Gene3D; 2.60.40.10; -; 11. DR InterPro; IPR013032; EGF-like_CS. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR013111; EGF_extracell. DR InterPro; IPR036056; Fibrinogen-like_C. DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom. DR InterPro; IPR003961; FN3_dom. DR InterPro; IPR036116; FN3_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR033078; TNC. DR PANTHER; PTHR19143:SF38; PTHR19143:SF38; 5. DR Pfam; PF07974; EGF_2; 4. DR Pfam; PF00147; Fibrinogen_C; 1. DR Pfam; PF00041; fn3; 11. DR SMART; SM00181; EGF; 14. DR SMART; SM00186; FBG; 1. DR SMART; SM00060; FN3; 11. DR SUPFAM; SSF49265; SSF49265; 8. DR SUPFAM; SSF56496; SSF56496; 1. DR PROSITE; PS00022; EGF_1; 5. DR PROSITE; PS01186; EGF_2; 5. DR PROSITE; PS50026; EGF_3; 5. DR PROSITE; PS51406; FIBRINOGEN_C_2; 1. DR PROSITE; PS50853; FN3; 11. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076}; KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076}; KW Proteomics identification {ECO:0000213|EPD:F5H7V9, KW ECO:0000213|MaxQB:F5H7V9, ECO:0000213|PeptideAtlas:F5H7V9}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 1838 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014571423. FT DOMAIN 186 217 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 280 311 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 373 404 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 466 497 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 559 590 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 625 715 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 716 804 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 805 896 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 897 986 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 987 1075 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1076 1165 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1167 1258 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1259 1348 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1349 1438 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1439 1525 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1526 1614 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1612 1827 Fibrinogen C-terminal. FT {ECO:0000259|PROSITE:PS51406}. FT COILED 119 139 {ECO:0000256|SAM:Coils}. FT DISULFID 190 200 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 207 216 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 284 294 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 301 310 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 377 387 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 394 403 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 470 480 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 487 496 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 563 573 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 580 589 {ECO:0000256|PROSITE-ProRule:PRU00076}. SQ SEQUENCE 1838 AA; 201143 MW; 752819DBC1DEBD3E CRC64; MGAMTQLLAG VFLAFLALAT EGGVLKKVIR HKRQSGVNAT LPEENQPVVF NHVYNIKLPV GSQCSVDLES ASGEKDLAPP SEPSESFQEH TVDGENQIVF THRINIPRRA CGCAAAPDVK ELLSRLEELE NLVSSLREQC TAGAGCCLQP ATGRLDTRPF CSGRGNFSTE GCGCVCEPGW KGPNCSEPEC PGNCHLRGRC IDGQCICDDG FTGEDCSQLA CPSDCNDQGK CVNGVCICFE GYAGADCSRE ICPVPCSEEH GTCVDGLCVC HDGFAGDDCN KPLCLNNCYN RGRCVENECV CDEGFTGEDC SELICPNDCF DRGRCINGTC YCEEGFTGED CGKPTCPHAC HTQGRCEEGQ CVCDEGFAGV DCSEKRCPAD CHNRGRCVDG RCECDDGFTG ADCGELKCPN GCSGHGRCVN GQCVCDEGYT GEDCSQLRCP NDCHSRGRCV EGKCVCEQGF KGYDCSDMSC PNDCHQHGRC VNGMCVCDDG YTGEDCRDRQ CPRDCSNRGL CVDGQCVCED GFTGPDCAEL SCPNDCHGQG RCVNGQCVCH EGFMGKDCKE QRCPSDCHGQ GRCVDGQCIC HEGFTGLDCG QHSCPSDCNN LGQCVSGRCI CNEGYSGEDC SEVSPPKDLV VTEVTEETVN LAWDNEMRVT EYLVVYTPTH EGGLEMQFRV PGDQTSTIIQ ELEPGVEYFI RVFAILENKK SIPVSARVAT YLPAPEGLKF KSIKETSVEV EWDPLDIAFE TWEIIFRNMN KEDEGEITKS LRRPETSYRQ TGLAPGQEYE ISLHIVKNNT RGPGLKRVTT TRLDAPSQIE VKDVTDTTAL ITWFKPLAEI DGIELTYGIK DVPGDRTTID LTEDENQYSI GNLKPDTEYE VSLISRRGDM SSNPAKETFT TGLDAPRNLR RVSQTDNSIT LEWRNGKAAI DSYRIKYAPI SGGDHAEVDV PKSQQATTKT TLTGLRPGTE YGIGVSAVKE DKESNPATIN AATELDTPKD LQVSETAETS LTLLWKTPLA KFDRYRLNYS LPTGQWVGVQ LPRNTTSYVL RGLEPGQEYN VLLTAEKGRH KSKPARVKAS TAKEPEIGNL NVSDITPESF NLSWMATDGI FETFTIEIID SNRLLETVEY NISGAERTAH ISGLPPSTDF IVYLSGLAPS IRTKTISATA TTEPKPQLGT LIFSNITPKS FNMSWTTQAG LFAKIVINVS DAHSLHESQQ FTVSGDAKQA HITGLVENTG YDVSVAGTTL AGDPTRPLTA FVITEAEPEV DNLLVSDATP DGFRLSWTAD EGVFDNFVLK IRDTKKQSEP LEITLLAPER TRDITGLREA TEYEIELYGI SKGRRSQTVS AIATTAMGSP KEVIFSDITE NSATVSWRAP TAQVESFRIT YVPITGGTPS MVTVDGTKTQ TRLVKLIPGV EYLVSIIAMK GFEESEPVSG SFTTALDGPS GLVTANITDS EALARWQPAI ATVDSYVISY TGEKVPEITR TVSGNTVEYA LTDLEPATEY TLRIFAEKGP QKSSTITAKF TTDLDSPRDL TATEVQSETA LLTWRPPRAS VTGYLLVYES VDGTVKEVIV GPDTTSYSLA DLSPSTHYTA KIQALNGPLR SNMIQTIFTT IGLLYPFPKD CSQAMLNGDT TSGLYTIYLN GDKAEALEVF CDMTSDGGGW IVFLRRKNGR ENFYQNWKAY AAGFGDRREE FWLGLDNLNK ITAQGQYELR VDLRDHGETA FAVYDKFSVG DAKTRYKLKV EGYSGTAGDS MAYHNGRSFS TFDKDTDSAI TNCALSYKGA FWYRNCHRVN LMGRYGDNNH SQGVNWFHWK GHEHSIQFAE MKLRPSNFRN LEGRRKRA //