ID F5H6I3_HUMAN Unreviewed; 753 AA. AC F5H6I3; DT 28-JUN-2011, integrated into UniProtKB/TrEMBL. DT 28-JUN-2011, sequence version 1. DT 16-JAN-2019, entry version 64. DE SubName: Full=Protein kinase C-binding protein NELL1 {ECO:0000313|Ensembl:ENSP00000317837}; GN Name=NELL1 {ECO:0000313|Ensembl:ENSP00000317837}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000317837, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000317837, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16554811; DOI=10.1038/nature04632; RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., RA Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T., RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., RA Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C., RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., RA Hattori M., Rogers J., Lander E.S., Sakaki Y.; RT "Human chromosome 11 DNA sequence and analysis including novel gene RT identification."; RL Nature 440:497-500(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000317837} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC010811; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC067794; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC069575; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC087279; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC090707; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC090857; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC099730; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC105190; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF455349; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001275643.1; NM_001288714.1. DR UniGene; Hs.657172; -. DR ProteinModelPortal; F5H6I3; -. DR PeptideAtlas; F5H6I3; -. DR PRIDE; F5H6I3; -. DR Ensembl; ENST00000325319; ENSP00000317837; ENSG00000165973. DR GeneID; 4745; -. DR UCSC; uc010rdo.4; human. DR CTD; 4745; -. DR EuPathDB; HostDB:ENSG00000165973.17; -. DR HGNC; HGNC:7750; NELL1. DR OpenTargets; ENSG00000165973; -. DR GeneTree; ENSGT00810000125439; -. DR OrthoDB; 767046at2759; -. DR ChiTaRS; NELL1; human. DR GenomeRNAi; 4745; -. DR Proteomes; UP000005640; Chromosome 11. DR Bgee; ENSG00000165973; Expressed in 116 organ(s), highest expression level in stomach. DR ExpressionAtlas; F5H6I3; baseline and differential. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR InterPro; IPR013320; ConA-like_dom_sf. DR InterPro; IPR001881; EGF-like_Ca-bd_dom. DR InterPro; IPR013032; EGF-like_CS. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site. DR InterPro; IPR018097; EGF_Ca-bd_CS. DR InterPro; IPR024731; EGF_dom. DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf. DR InterPro; IPR001791; Laminin_G. DR InterPro; IPR001007; VWF_dom. DR Pfam; PF12947; EGF_3; 1. DR Pfam; PF07645; EGF_CA; 3. DR Pfam; PF00093; VWC; 2. DR SMART; SM00181; EGF; 6. DR SMART; SM00179; EGF_CA; 5. DR SMART; SM00210; TSPN; 1. DR SMART; SM00214; VWC; 4. DR SMART; SM00215; VWC_out; 2. DR SUPFAM; SSF49899; SSF49899; 1. DR SUPFAM; SSF57184; SSF57184; 1. DR PROSITE; PS00010; ASX_HYDROXYL; 3. DR PROSITE; PS00022; EGF_1; 1. DR PROSITE; PS01186; EGF_2; 3. DR PROSITE; PS50026; EGF_3; 5. DR PROSITE; PS01187; EGF_CA; 2. DR PROSITE; PS01208; VWFC_1; 2. DR PROSITE; PS50184; VWFC_2; 2. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076, KW ECO:0000256|SAAS:SAAS00601599}; KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076, KW ECO:0000256|SAAS:SAAS00032677}; KW Proteomics identification {ECO:0000213|PeptideAtlas:F5H6I3}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Repeat {ECO:0000256|SAAS:SAAS00594563}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 753 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003327275. FT DOMAIN 214 275 VWFC. {ECO:0000259|PROSITE:PS50184}. FT DOMAIN 377 418 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 419 459 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 460 490 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 492 530 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 539 574 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 635 693 VWFC. {ECO:0000259|PROSITE:PS50184}. FT COILED 183 203 {ECO:0000256|SAM:Coils}. FT DISULFID 462 472 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 480 489 {ECO:0000256|PROSITE-ProRule:PRU00076}. SQ SEQUENCE 753 AA; 83040 MW; 11014AE7C48DFDF9 CRC64; MPMDLILVVW FCVCTARTVV GFGMDPDLQM DIVTELDLVN TTLGVAQVSG MHNASKAFLF QDIEREIHAA PHVSEKLIQL FRNKSEFTIL ATVQQKPSTS GVILSIRELE HRIYERVIDP PDTNLPPGIN LWLGQRNQKH GLFKGIIQDG KIIFMPNGYI TQCPNLNHTC PTCSDFLSLV QGIMDLQELL AKMTAKLNYA ETRLSQLENC HCEKTCQVSG LLYRDQDSWV DGDHCRNCTC KSGAVECRRM SCPPLNCSPD SLPVHIAGQC CKVCRPKCIY GGKVLAEGQR ILTKSCRECR GGVLVKITEM CPPLNCSEKD HILPENQCCR VCRGHNFCAE GPKCGENSEC KNWNTKATCE CKSGYISVQG DSAYCEDIDE CAAKMHYCHA NTVCVNLPGL YRCDCVPGYI RVDDFSCTEH DECGSGQHNC DENAICTNTV QGHSCTCKPG YVGNGTICRA FCEEGCRYGG TCVAPNKCVC PSGFTGSHCE KDIDECSEGI IECHNHSRCV NLPGWYHCEC RSGFHDDGTY SLSGESCIDI DECALRTHTC WNDSACINLA GGFDCLCPSG PSCSGDCPHE GGLKHNGQVW TLKEDRCSVC SCKDGKIFCR RTACDCQNPS ADLFCCPECD TRVTSQCLDQ NGHKLYRSGD NWTHSCQQCR CLEGEVDCWP LTCPNLSCEY TAILEGECCP RCVSDPCLAD NITYDIRKTC LDSYGVSRLS GSVWTMAGSP CTTCKCKNGR VCCSVDFECL QNN //