ID F5H6I0_HUMAN Unreviewed; 101 AA. AC F5H6I0; DT 28-JUN-2011, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 2. DT 16-JAN-2019, entry version 71. DE RecName: Full=Beta-2-microglobulin {ECO:0000256|SAAS:SAAS00327869}; GN Name=B2M {ECO:0000313|Ensembl:ENSP00000437604}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000437604, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000437604, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16572171; DOI=10.1038/nature04601; RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S., RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., RA Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., RA Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., RA Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., RA Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., RA Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K., RA Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., RA Nusbaum C.; RT "Analysis of the DNA sequence and duplication history of human RT chromosome 15."; RL Nature 440:671-675(2006). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000313|Ensembl:ENSP00000437604} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [4] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [5] {ECO:0000313|Ensembl:ENSP00000483449} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- FUNCTION: Component of the class I major histocompatibility CC complex (MHC). Involved in the presentation of peptide antigens to CC the immune system. {ECO:0000256|SAAS:SAAS00319106}. CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain. Beta-2- CC microglobulin is the beta-chain of major histocompatibility CC complex class I molecules. {ECO:0000256|SAAS:SAAS00319097}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00319104}. CC -!- SIMILARITY: Belongs to the beta-2-microglobulin family. CC {ECO:0000256|SAAS:SAAS00551745}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC018901; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC025270; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC122108; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR SMR; F5H6I0; -. DR jPOST; F5H6I0; -. DR PeptideAtlas; F5H6I0; -. DR PRIDE; F5H6I0; -. DR Ensembl; ENST00000544417; ENSP00000437604; ENSG00000166710. DR Ensembl; ENST00000619603; ENSP00000483449; ENSG00000273686. DR UCSC; uc059iqm.1; human. DR EuPathDB; HostDB:ENSG00000166710.17; -. DR HGNC; HGNC:914; B2M. DR OpenTargets; ENSG00000166710; -. DR GeneTree; ENSGT00690000102227; -. DR ChiTaRS; B2M; human. DR Proteomes; UP000005640; Chromosome 15. DR Bgee; ENSG00000166710; Expressed in 234 organ(s), highest expression level in leukocyte. DR ExpressionAtlas; F5H6I0; baseline and differential. DR GO; GO:0005829; C:cytosol; IDA:HPA. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0005794; C:Golgi apparatus; IDA:HPA. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IDA:HPA. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR InterPro; IPR015707; B2Microglobulin. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR PANTHER; PTHR19944:SF62; PTHR19944:SF62; 1. DR Pfam; PF07654; C1-set; 1. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Immunity {ECO:0000256|SAAS:SAAS00436621}; KW Immunoglobulin domain {ECO:0000256|SAAS:SAAS00436620}; KW MHC I {ECO:0000256|SAAS:SAAS00436621}; KW Proteomics identification {ECO:0000213|EPD:F5H6I0, KW ECO:0000213|MaxQB:F5H6I0, ECO:0000213|PeptideAtlas:F5H6I0}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Secreted {ECO:0000256|SAAS:SAAS00436616}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 101 Beta-2-microglobulin. FT {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014089790. FT DOMAIN 33 92 IGc1. {ECO:0000259|SMART:SM00407}. SQ SEQUENCE 101 AA; 11732 MW; 618597495A616CEA CRC64; MSRSVALAVL ALLSLSGLEA IQRTPKIQVY SRHPADIEVD LLKNGERIEK VEHSDLSFSK DWSFYLLYYT EFTPTEKDEY ACRVNHVTLS QPKIVKWDRD M //