ID   F5H5X9_HUMAN            Unreviewed;       630 AA.
AC   F5H5X9;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   16-JAN-2019, entry version 57.
DE   SubName: Full=Cadherin-7 {ECO:0000313|Ensembl:ENSP00000443030};
GN   Name=CDH7 {ECO:0000313|Ensembl:ENSP00000443030};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000443030, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000443030, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16177791; DOI=10.1038/nature03983;
RA   Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D.,
RA   Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S.,
RA   Bloom T., Bugalter B., Butler J., Cook A., DeCaprio D., Engels R.,
RA   Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T.,
RA   Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E.,
RA   Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H.,
RA   O'Leary S.B., O'Neill K., Piqani B., Smith C.L., Talamas J.A.,
RA   Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q.,
RA   Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 18.";
RL   Nature 437:551-555(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000443030}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|SAAS:SAAS01075634}; Single-pass type I membrane
CC       protein {ECO:0000256|SAAS:SAAS01075634}.
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DR   EMBL; AC023394; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC090358; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001304143.1; NM_001317214.1.
DR   UniGene; Hs.541003; -.
DR   UniGene; Hs.657522; -.
DR   ProteinModelPortal; F5H5X9; -.
DR   PeptideAtlas; F5H5X9; -.
DR   PRIDE; F5H5X9; -.
DR   Ensembl; ENST00000536984; ENSP00000443030; ENSG00000081138.
DR   GeneID; 1005; -.
DR   UCSC; uc002lka.4; human.
DR   CTD; 1005; -.
DR   EuPathDB; HostDB:ENSG00000081138.13; -.
DR   HGNC; HGNC:1766; CDH7.
DR   OpenTargets; ENSG00000081138; -.
DR   eggNOG; KOG3594; Eukaryota.
DR   eggNOG; ENOG410XQHI; LUCA.
DR   GeneTree; ENSGT00940000157031; -.
DR   OrthoDB; 217088at2759; -.
DR   ChiTaRS; CDH7; human.
DR   GenomeRNAi; 1005; -.
DR   Proteomes; UP000005640; Chromosome 18.
DR   Bgee; ENSG00000081138; Expressed in 62 organ(s), highest expression level in kidney.
DR   ExpressionAtlas; F5H5X9; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   InterPro; IPR039808; Cadherin.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   PANTHER; PTHR24027; PTHR24027; 1.
DR   Pfam; PF00028; Cadherin; 5.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 5.
DR   SUPFAM; SSF49313; SSF49313; 5.
DR   PROSITE; PS00232; CADHERIN_1; 2.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|SAAS:SAAS00020193};
KW   Cell adhesion {ECO:0000256|SAAS:SAAS01075623};
KW   Cell membrane {ECO:0000256|SAAS:SAAS01075618};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00616217,
KW   ECO:0000256|SAAS:SAAS01075618, ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|SAAS:SAAS01075609};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:F5H5X9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00436611};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00616217,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00616217,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     27       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        28    630       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003324764.
FT   TRANSMEM    599    621       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       70    151       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      175    260       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      284    376       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      399    480       CA. {ECO:0000259|SMART:SM00112}.
FT   DOMAIN      503    590       CA. {ECO:0000259|SMART:SM00112}.
SQ   SEQUENCE   630 AA;  69244 MW;  5EABE084BE10DFFF CRC64;
     MKLGKVEFCH FLQLIALFLC FSGMSQAELS RSRSKPYFQS GRSRTKRSWV WNQFFVLEEY
     MGSDPLYVGK LHSDVDKGDG SIKYILSGEG ASSIFIIDEN TGDIHATKRL DREEQAYYTL
     RAQALDRLTN KPVEPESEFV IKIQDINDNE PKFLDGPYTA GVPEMSPVGT SVVQVTATDA
     DDPTYGNSAR VVYSILQGQP YFSVEPKTGV IKTALPNMDR EAKDQYLLVI QAKDMVGQNG
     GLSGTTSVTV TLTDVNDNPP RFPRRSYQYN VPESLPVASV VARIKAADAD IGANAEMEYK
     IVDGDGLGIF KISVDKETQE GIITIQKELD FEAKTSYTLR IEAANKDADP RFLSLGPFSD
     TTTVKIIVED VDEPPVFSSP LYPMEVSEAT QVGNIIGTVA AHDPDSSNSP VRYSIDRNTD
     LERYFNIDAN SGVITTAKSL DRETNAIHNI TVLAMESQNP SQVGRGYVAI TILDINDNAP
     EFAMDYETTV CENAQPGQVI QKISAVDKDE PSNGHQFYFS LTTDATNNHN FSLKDNKDNT
     ASILTRRNGF RRQEQSVYYL PIFIVDSGSP SLSSTNTLTI RVCDCDADGV AQTCNAEAYV
     LPAGLSTGAL IAILACVLTL LGRYCFQGLL
//