ID   F5H4Z8_HUMAN            Unreviewed;       947 AA.
AC   F5H4Z8;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 2.
DT   16-JAN-2019, entry version 65.
DE   SubName: Full=Thrombospondin-3 {ECO:0000313|Ensembl:ENSP00000444792};
GN   Name=THBS3 {ECO:0000313|Ensembl:ENSP00000444792};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000444792, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000444792, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA   Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA   James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA   Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA   Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA   Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA   Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA   Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA   Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA   Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA   Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA   Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA   Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA   Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA   Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA   Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA   Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA   Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA   Porter K.M., Prigmore E.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000444792}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; AC234582; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001239536.1; NM_001252607.1.
DR   UniGene; Hs.169875; -.
DR   UniGene; Hs.658188; -.
DR   ProteinModelPortal; F5H4Z8; -.
DR   jPOST; F5H4Z8; -.
DR   PeptideAtlas; F5H4Z8; -.
DR   PRIDE; F5H4Z8; -.
DR   Ensembl; ENST00000541576; ENSP00000444792; ENSG00000169231.
DR   GeneID; 7059; -.
DR   UCSC; uc009wqi.4; human.
DR   CTD; 7059; -.
DR   EuPathDB; HostDB:ENSG00000169231.13; -.
DR   HGNC; HGNC:11787; THBS3.
DR   OpenTargets; ENSG00000169231; -.
DR   eggNOG; ENOG410IFQQ; Eukaryota.
DR   eggNOG; ENOG410XQKE; LUCA.
DR   GeneTree; ENSGT00940000159283; -.
DR   OrthoDB; 120983at2759; -.
DR   ChiTaRS; THBS3; human.
DR   GenomeRNAi; 7059; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000169231; Expressed in 187 organ(s), highest expression level in tibia.
DR   ExpressionAtlas; F5H4Z8; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008201; F:heparin binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   Gene3D; 4.10.1080.10; -; 3.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR024665; Thbs/COMP_coiled-coil.
DR   InterPro; IPR037349; Thrombospondin.
DR   InterPro; IPR028507; Thrombospondin-3.
DR   InterPro; IPR003367; Thrombospondin_3-like_rpt.
DR   InterPro; IPR017897; Thrombospondin_3_rpt.
DR   InterPro; IPR008859; Thrombospondin_C.
DR   InterPro; IPR028974; TSP_type-3_rpt.
DR   PANTHER; PTHR10199; PTHR10199; 1.
DR   PANTHER; PTHR10199:SF89; PTHR10199:SF89; 1.
DR   Pfam; PF11598; COMP; 1.
DR   Pfam; PF07645; EGF_CA; 2.
DR   Pfam; PF02412; TSP_3; 6.
DR   Pfam; PF05735; TSP_C; 1.
DR   SMART; SM00181; EGF; 4.
DR   SMART; SM00179; EGF_CA; 2.
DR   SMART; SM00210; TSPN; 1.
DR   SUPFAM; SSF103647; SSF103647; 3.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 3.
DR   PROSITE; PS01187; EGF_CA; 2.
DR   PROSITE; PS51234; TSP3; 8.
DR   PROSITE; PS51236; TSP_CTER; 1.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00634};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00601599};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00032677};
KW   Proteomics identification {ECO:0000213|MaxQB:F5H4Z8,
KW   ECO:0000213|PeptideAtlas:F5H4Z8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00966518};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    947       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003327266.
FT   DOMAIN      307    345       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      361    401       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      405    447       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   REPEAT      448    482       TSP type-3. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00634}.
FT   REPEAT      483    518       TSP type-3. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00634}.
FT   REPEAT      519    541       TSP type-3. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00634}.
FT   REPEAT      542    577       TSP type-3. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00634}.
FT   REPEAT      578    600       TSP type-3. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00634}.
FT   REPEAT      601    638       TSP type-3. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00634}.
FT   REPEAT      639    678       TSP type-3. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00634}.
FT   REPEAT      679    714       TSP type-3. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00634}.
FT   DOMAIN      718    932       TSP C-terminal.
FT                                {ECO:0000259|PROSITE:PS51236}.
SQ   SEQUENCE   947 AA;  103252 MW;  6AF1BBAEA5713511 CRC64;
     METQELRGAL ALLLLCFFTS ASQDLQVIDL LTVGESRQMV AVAEKIRTAL LTAGDIYLLS
     TFRLPPKQGG VLFGLYSRQD NTRWLEASVV GKINKVLVRY QREDGKVHAV NLQQAGLADG
     RTHTVLLRLR GPSRPSPALH LYVDCKLGDQ HAGLPALAPI PPAEVDGLEI RTGQKAYLRM
     QGFVESMKII LGGSMARVGA LSECPFQGDE SIHSAGEQTK ALVTQLTLFN QILVELRDDI
     RDQVKEMSLI RNTIMECQVC GFHEQRSHCS PNPCFRGVDC MEVYEYPGYR CGPCPPGLQG
     NGTHCSDINE CAHADPCFPG SSCINTMPGF HCEACPRGYK GTQVSGVGID YARASKQVCN
     DIDECNDGNN GGCDPNSICT NTVGSFKCGP CRLGFLGNQS QGCLPARTCH SPAHSPCHIH
     AHCLFERNGA VSCQCNVGWA GNGNVCGTDT DIDGYPDQAL PCMDNNKHCK QDNCLLTPNS
     GQEDADNDGV GDQCDDDADG DGIKNVEDNC RLFPNKDQQN SDTDSFGDAC DNCPNVPNND
     QKDTDGNGEG DACDNDVDGD GIPNGLDNCP KVPNPLQTDR DEDGVGDACD SCPEMSNPTQ
     TDADSDLVGD VCDTNEDSDG DGHQDTKDNC PQLPNSSQLD SDNDGLGDEC DGDDDNDGIP
     DYVPPGPDNC RLVPNPNQKD SDGNGVGDVC EDDFDNDAVV DPLDVCPESA EVTLTDFRAY
     QTVVLDPEGD AQIDPNWVVL NQGMEIVQTM NSDPGLAVGY TAFNGVDFEG TFHVNTVTDD
     DYAGFLFSYQ DSGRFYVVMW KQTEQTYWQA TPFRAVAQPG LQLKAVTSVS GPGEHLRNAL
     WHTGHTPDQV RLLWTDPRNV GWRDKTSYRW QLLHRPQVGY IRVKLYEGPQ LVADSGVIID
     TSMRGGRLGV FCFSQENIIW SNLQYRCNDT VPEDFEPFRR QLLQGRV
//