ID   F5H4X8_HUMAN            Unreviewed;       194 AA.
AC   F5H4X8;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   16-JAN-2019, entry version 62.
DE   RecName: Full=FXYD domain-containing ion transport regulator {ECO:0000256|RuleBase:RU364131};
GN   Name=FXYD5 {ECO:0000313|Ensembl:ENSP00000444839};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000444839, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000444839, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000444839}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:22814378}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA   Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA   Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA   Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA   Aldabe R.;
RT   "N-terminal acetylome analyses and functional insights of the N-
RT   terminal acetyltransferase NatB.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN   [4] {ECO:0000313|Ensembl:ENSP00000467053}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the FXYD family.
CC       {ECO:0000256|RuleBase:RU364131}.
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DR   EMBL; AC002390; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC020907; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001307841.1; NM_001320912.1.
DR   UniGene; Hs.333418; -.
DR   SMR; F5H4X8; -.
DR   jPOST; F5H4X8; -.
DR   MaxQB; F5H4X8; -.
DR   PeptideAtlas; F5H4X8; -.
DR   PRIDE; F5H4X8; -.
DR   Ensembl; ENST00000543307; ENSP00000444839; ENSG00000089327.
DR   Ensembl; ENST00000588699; ENSP00000467053; ENSG00000089327.
DR   GeneID; 53827; -.
DR   UCSC; uc010xsq.3; human.
DR   CTD; 53827; -.
DR   EuPathDB; HostDB:ENSG00000089327.14; -.
DR   HGNC; HGNC:4029; FXYD5.
DR   OpenTargets; ENSG00000089327; -.
DR   GeneTree; ENSGT00940000163838; -.
DR   OMA; PFFYDED; -.
DR   OrthoDB; 1455172at2759; -.
DR   ChiTaRS; FXYD5; human.
DR   GenomeRNAi; 53827; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000089327; Expressed in 190 organ(s), highest expression level in ectocervix.
DR   ExpressionAtlas; F5H4X8; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0043269; P:regulation of ion transport; IEA:InterPro.
DR   InterPro; IPR000272; Ion-transport_regulator_FXYD.
DR   Pfam; PF02038; ATP1G1_PLM_MAT8; 1.
DR   ProDom; PD005989; PD005989; 1.
DR   PROSITE; PS01310; FXYD; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Ion transport {ECO:0000256|RuleBase:RU364131};
KW   Proteomics identification {ECO:0000213|MaxQB:F5H4X8,
KW   ECO:0000213|PeptideAtlas:F5H4X8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|RuleBase:RU364131};
KW   Transport {ECO:0000256|RuleBase:RU364131}.
FT   SIGNAL        1     21       {ECO:0000256|RuleBase:RU364131}.
FT   CHAIN        22    194       FXYD domain-containing ion transport
FT                                regulator.
FT                                {ECO:0000256|RuleBase:RU364131}.
FT                                /FTId=PRO_5013982299.
SQ   SEQUENCE   194 AA;  21092 MW;  DC72E64276C81AA4 CRC64;
     MSPSGRLCLL TIVGLILPTR GQTLKDTTSS SSADSTIMDI QVPTRAPDAV YTELQPTSPT
     PTWPADETPQ PQTQTQQLEG TDGPLVTDPE THKSTKAAHP TDDTTTLSER PSPSTDVQTD
     PQTLKPSGFH EDDPFFYDEH TLRKRGLLVA AVLFITGIII LTSENWGWVG RTPRPGGGLM
     TEGWVLKGPW AILF
//