ID   F5H4M7_HUMAN            Unreviewed;       155 AA.
AC   F5H4M7;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   13-FEB-2019, entry version 62.
DE   SubName: Full=Transmembrane emp24 domain-containing protein 3 {ECO:0000313|Ensembl:ENSP00000446062};
GN   Name=TMED3 {ECO:0000313|Ensembl:ENSP00000446062};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000446062, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000446062, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
RA   Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
RA   Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
RA   Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
RA   Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
RA   Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K.,
RA   Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
RA   Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human
RT   chromosome 15.";
RL   Nature 440:671-675(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000446062}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003827};
CC       Single-pass type I membrane protein
CC       {ECO:0000256|RuleBase:RU003827}.
CC   -!- SIMILARITY: Belongs to the EMP24/GP25L family.
CC       {ECO:0000256|RuleBase:RU003827, ECO:0000256|SAAS:SAAS00561910}.
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DR   EMBL; AC011797; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC027811; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF456105; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF459564; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001288132.1; NM_001301203.1.
DR   UniGene; Hs.513058; -.
DR   UniGene; Hs.665470; -.
DR   UniGene; Hs.71608; -.
DR   ProteinModelPortal; F5H4M7; -.
DR   SMR; F5H4M7; -.
DR   jPOST; F5H4M7; -.
DR   MaxQB; F5H4M7; -.
DR   PeptideAtlas; F5H4M7; -.
DR   PRIDE; F5H4M7; -.
DR   Ensembl; ENST00000536821; ENSP00000446062; ENSG00000166557.
DR   GeneID; 23423; -.
DR   UCSC; uc059mhp.1; human.
DR   CTD; 23423; -.
DR   EuPathDB; HostDB:ENSG00000166557.12; -.
DR   HGNC; HGNC:28889; TMED3.
DR   OpenTargets; ENSG00000166557; -.
DR   GeneTree; ENSGT00940000159833; -.
DR   OrthoDB; 1328081at2759; -.
DR   ChiTaRS; TMED3; human.
DR   GenomeRNAi; 23423; -.
DR   Proteomes; UP000005640; Chromosome 15.
DR   Bgee; ENSG00000166557; Expressed in 221 organ(s), highest expression level in parotid gland.
DR   ExpressionAtlas; F5H4M7; baseline and differential.
DR   GO; GO:0005794; C:Golgi apparatus; IDA:HPA.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR009038; GOLD_dom.
DR   InterPro; IPR036598; GOLD_dom_sf.
DR   InterPro; IPR015720; TMP21-related.
DR   PANTHER; PTHR22811; PTHR22811; 1.
DR   Pfam; PF01105; EMP24_GP25L; 1.
DR   SMART; SM01190; EMP24_GP25L; 1.
DR   SUPFAM; SSF101576; SSF101576; 1.
DR   PROSITE; PS50866; GOLD; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00561904};
KW   Proteomics identification {ECO:0000213|EPD:F5H4M7,
KW   ECO:0000213|MaxQB:F5H4M7, ECO:0000213|PeptideAtlas:F5H4M7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00561904};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00561904}.
FT   SIGNAL        1     27       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        28    155       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003323076.
FT   DOMAIN       38    120       GOLD. {ECO:0000259|PROSITE:PS50866}.
SQ   SEQUENCE   155 AA;  17423 MW;  B14AAAE93805E837 CRC64;
     MGSTVPRSAS VLLLLLLLRR AEQPCGAELT FELPDNAKQC FHEEVEQGVK FSLDYQVITG
     GHYDVDCYVE DPQGNTIYRE TKKQYDSFTY RAEVKGVYQF CFSNEFSTFS HKTVYFDFQV
     GDEPPILPDM GNRVTALTQG PSASPTPTPP LRVPV
//