ID   F5H4E2_HUMAN            Unreviewed;       111 AA.
AC   F5H4E2;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   12-SEP-2018, entry version 48.
DE   SubName: Full=SPARC {ECO:0000313|Ensembl:ENSP00000444998};
DE   Flags: Fragment;
GN   Name=SPARC {ECO:0000313|Ensembl:ENSP00000444998};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000444998, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000444998, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000444998}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC011374; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   MaxQB; F5H4E2; -.
DR   PeptideAtlas; F5H4E2; -.
DR   PRIDE; F5H4E2; -.
DR   Ensembl; ENST00000539687; ENSP00000444998; ENSG00000113140.
DR   UCSC; uc063ivv.1; human.
DR   EuPathDB; HostDB:ENSG00000113140.10; -.
DR   HGNC; HGNC:11219; SPARC.
DR   OpenTargets; ENSG00000113140; -.
DR   eggNOG; KOG4004; Eukaryota.
DR   eggNOG; ENOG41101WW; LUCA.
DR   GeneTree; ENSGT00510000046787; -.
DR   ChiTaRS; SPARC; human.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000113140; Expressed in 232 organ(s), highest expression level in tibia.
DR   ExpressionAtlas; F5H4E2; baseline and differential.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005518; F:collagen binding; IEA:InterPro.
DR   InterPro; IPR003645; Fol_N.
DR   InterPro; IPR015369; Follistatin/Osteonectin_EGF.
DR   InterPro; IPR001999; Osteonectin_CS.
DR   InterPro; IPR037641; SPARC.
DR   PANTHER; PTHR13866; PTHR13866; 1.
DR   Pfam; PF09289; FOLN; 1.
DR   SMART; SM00274; FOLN; 1.
DR   PROSITE; PS00612; OSTEONECTIN_1; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:F5H4E2,
KW   ECO:0000213|PeptideAtlas:F5H4E2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18    111       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003327259.
FT   DOMAIN       71     94       Follistatin-like.
FT                                {ECO:0000259|SMART:SM00274}.
FT   NON_TER     111    111       {ECO:0000313|Ensembl:ENSP00000444998}.
SQ   SEQUENCE   111 AA;  12100 MW;  EB3A8AF2412557CE CRC64;
     MRAWIFFLLC LAGRALAAPQ QEALPDETEV VEETVAEVTE VSVGANPVQV EVGEFDDGAE
     ETEEEVVAEN PCQNHHCKHG KVCELDENNT PMCVCQDPTS CPAPIGEFEK V
//