ID   CC080_HUMAN             Reviewed;         247 AA.
AC   F5H4A9; Q8N5S4;
DT   19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   16-JAN-2019, entry version 47.
DE   RecName: Full=Uncharacterized membrane protein C3orf80;
DE   Flags: Precursor;
GN   Name=C3orf80;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 70-247.
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AC112641; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC031660; AAH31660.1; -; mRNA.
DR   CCDS; CCDS54667.1; -.
DR   RefSeq; NP_001161686.1; NM_001168214.1.
DR   UniGene; Hs.729755; -.
DR   ProteinModelPortal; F5H4A9; -.
DR   iPTMnet; F5H4A9; -.
DR   PhosphoSitePlus; F5H4A9; -.
DR   BioMuta; C3orf80; -.
DR   PaxDb; F5H4A9; -.
DR   PRIDE; F5H4A9; -.
DR   ProteomicsDB; 26516; -.
DR   Ensembl; ENST00000326474; ENSP00000313324; ENSG00000180044.
DR   GeneID; 401097; -.
DR   KEGG; hsa:401097; -.
DR   UCSC; uc021xgp.2; human.
DR   CTD; 401097; -.
DR   EuPathDB; HostDB:ENSG00000180044.4; -.
DR   GeneCards; C3orf80; -.
DR   HGNC; HGNC:40048; C3orf80.
DR   HPA; HPA047439; -.
DR   neXtProt; NX_F5H4A9; -.
DR   OpenTargets; ENSG00000180044; -.
DR   eggNOG; ENOG410J1IG; Eukaryota.
DR   eggNOG; ENOG410YWJI; LUCA.
DR   GeneTree; ENSGT00390000005823; -.
DR   InParanoid; F5H4A9; -.
DR   OMA; CAELACG; -.
DR   OrthoDB; 1385214at2759; -.
DR   PhylomeDB; F5H4A9; -.
DR   TreeFam; TF337543; -.
DR   GenomeRNAi; 401097; -.
DR   PRO; PR:F5H4A9; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000180044; Expressed in 113 organ(s), highest expression level in Brodmann (1909) area 23.
DR   ExpressionAtlas; F5H4A9; baseline and differential.
DR   Genevisible; F5H4A9; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR031696; DUF4719.
DR   PANTHER; PTHR38505; PTHR38505; 1.
DR   Pfam; PF15843; DUF4719; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Glycoprotein; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL        1     35       {ECO:0000255}.
FT   CHAIN        36    247       Uncharacterized membrane protein C3orf80.
FT                                /FTId=PRO_0000413691.
FT   TRANSMEM     82    102       Helical. {ECO:0000255}.
FT   COMPBIAS     20     31       Poly-Leu.
FT   CARBOHYD     57     57       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
SQ   SEQUENCE   247 AA;  25682 MW;  2EA426CB6B95DC9B CRC64;
     MWGPGVTAEG LSVAPAPPPL LPLLLLLALA LVAPSRGGGG CAELACGERE RCCDATNATA
     VRCCKLPLHA FLDNVGWFVR KLSGLLILLV LFAIGYFLQR IICPSPRRYP RGQARPGQRP
     GPPGGAGPLG GAGPPDDDDD SPALLRDEAA AGSQDSLLDS GGGGRGRGGG GRSDPSCASE
     HEMRVVSPVF LQLPSYEEVK YLPTYEESMR LQQLSPGEVV LPVSVLGRPR GGVAAEPDGG
     EGRYPLI
//