ID   F5H496_HUMAN            Unreviewed;       145 AA.
AC   F5H496;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   16-JAN-2019, entry version 57.
DE   RecName: Full=Claudin {ECO:0000256|RuleBase:RU060637};
GN   Name=CLDN7 {ECO:0000313|Ensembl:ENSP00000445131};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000445131, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000445131, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000445131}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Plays a major role in tight junction-specific
CC       obliteration of the intercellular space, through calcium-
CC       independent cell-adhesion activity.
CC       {ECO:0000256|RuleBase:RU060637}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|SAAS:SAAS00567644}; Multi-pass membrane protein
CC       {ECO:0000256|SAAS:SAAS00567644}.
CC   -!- SIMILARITY: Belongs to the claudin family.
CC       {ECO:0000256|RuleBase:RU060637, ECO:0000256|SAAS:SAAS00567656}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU060637}.
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DR   EMBL; AC003688; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001171952.1; NM_001185023.1.
DR   UniGene; Hs.513915; -.
DR   ProteinModelPortal; F5H496; -.
DR   SMR; F5H496; -.
DR   jPOST; F5H496; -.
DR   MaxQB; F5H496; -.
DR   PeptideAtlas; F5H496; -.
DR   PRIDE; F5H496; -.
DR   DNASU; 1366; -.
DR   Ensembl; ENST00000538261; ENSP00000445131; ENSG00000181885.
DR   GeneID; 1366; -.
DR   UCSC; uc010cmc.4; human.
DR   CTD; 1366; -.
DR   EuPathDB; HostDB:ENSG00000181885.18; -.
DR   HGNC; HGNC:2049; CLDN7.
DR   OpenTargets; ENSG00000181885; -.
DR   eggNOG; ENOG410IHPN; Eukaryota.
DR   eggNOG; ENOG4111GPP; LUCA.
DR   GeneTree; ENSGT00940000160672; -.
DR   OrthoDB; 1244077at2759; -.
DR   ChiTaRS; CLDN7; human.
DR   GenomeRNAi; 1366; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000181885; Expressed in 143 organ(s), highest expression level in mucosa of transverse colon.
DR   ExpressionAtlas; F5H496; baseline and differential.
DR   Genevisible; F5H496; HS.
DR   GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-UniRule.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR006187; Claudin.
DR   InterPro; IPR003552; Claudin7.
DR   InterPro; IPR017974; Claudin_CS.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   PANTHER; PTHR12002; PTHR12002; 1.
DR   Pfam; PF00822; PMP22_Claudin; 1.
DR   PRINTS; PR01381; CLAUDIN7.
DR   PROSITE; PS01346; CLAUDIN; 1.
PE   1: Evidence at protein level;
KW   Cell junction {ECO:0000256|RuleBase:RU060637,
KW   ECO:0000256|SAAS:SAAS00455883};
KW   Cell membrane {ECO:0000256|RuleBase:RU060637,
KW   ECO:0000256|SAAS:SAAS00455877};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|RuleBase:RU060637,
KW   ECO:0000256|SAAS:SAAS00455877, ECO:0000256|SAAS:SAAS00463381};
KW   Proteomics identification {ECO:0000213|MaxQB:F5H496,
KW   ECO:0000213|PeptideAtlas:F5H496};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Tight junction {ECO:0000256|RuleBase:RU060637,
KW   ECO:0000256|SAAS:SAAS00455883};
KW   Transmembrane {ECO:0000256|RuleBase:RU060637,
KW   ECO:0000256|SAAS:SAAS00463381};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU060637,
KW   ECO:0000256|SAAS:SAAS00463381}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    145       Claudin. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003327256.
FT   TRANSMEM     70     97       Helical. {ECO:0000256|RuleBase:RU060637}.
FT   TRANSMEM    118    139       Helical. {ECO:0000256|RuleBase:RU060637}.
SQ   SEQUENCE   145 AA;  15156 MW;  A6ADFAD00862343C CRC64;
     MANSGLQLLG FSMALLGWVG LVACTAIPQW QMSSYAGDNI ITAQAMYKGL WMDCVTQSTG
     MMSCKMYDSV LALSAALQAT RALMVVSLVL GFLAMFVATM GMKCTRCGGD DKVKKARIAM
     GGGIIFIVAG MSLALPSLLA GQGLP
//