ID   F5H3U5_HUMAN            Unreviewed;       192 AA.
AC   F5H3U5;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   16-JAN-2019, entry version 43.
DE   SubName: Full=Acyl-CoA (8-3)-desaturase {ECO:0000313|Ensembl:ENSP00000439097};
GN   Name=FADS1 {ECO:0000313|Ensembl:ENSP00000439097};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000439097, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000439097, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000439097}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AP002380; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; F5H3U5; -.
DR   jPOST; F5H3U5; -.
DR   MaxQB; F5H3U5; -.
DR   PeptideAtlas; F5H3U5; -.
DR   PRIDE; F5H3U5; -.
DR   Ensembl; ENST00000536991; ENSP00000439097; ENSG00000149485.
DR   UCSC; uc058cel.1; human.
DR   EuPathDB; HostDB:ENSG00000149485.16; -.
DR   HGNC; HGNC:3574; FADS1.
DR   OpenTargets; ENSG00000149485; -.
DR   eggNOG; KOG4232; Eukaryota.
DR   eggNOG; ENOG410XVSZ; LUCA.
DR   GeneTree; ENSGT00940000153697; -.
DR   ChiTaRS; FADS1; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000149485; Expressed in 232 organ(s), highest expression level in mammalian vulva.
DR   ExpressionAtlas; F5H3U5; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   InterPro; IPR005804; FA_desaturase_dom.
DR   Pfam; PF00487; FA_desaturase; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:F5H3U5,
KW   ECO:0000213|MaxQB:F5H3U5, ECO:0000213|PeptideAtlas:F5H3U5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     16       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        17    192       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003324758.
FT   TRANSMEM     50     74       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       32    165       FA_desaturase.
FT                                {ECO:0000259|Pfam:PF00487}.
SQ   SEQUENCE   192 AA;  22729 MW;  8F5B363E4A1DC706 CRC64;
     MTFLCSCLLF VSVSSPVGPP ALLPLYFQWY IFYFVIQRKK WVDLAWMITF YVRFFLTYVP
     LLGLKAFLGL FFIVRFLESN WFVWVTQMNH IPMHIDHDRN MDWVSTQLQA TCNVHKSAFN
     DWFSGHLNFQ IEHHLFPTMP RHNYHKVAPL VQSLCAKHGI EYQSKPLLSA FADIIHSLKE
     SGQLWLDAYL HQ
//