ID   F5H2D0_HUMAN            Unreviewed;       671 AA.
AC   F5H2D0;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 3.
DT   16-JAN-2019, entry version 69.
DE   SubName: Full=Complement C1r subcomponent {ECO:0000313|Ensembl:ENSP00000438636};
GN   Name=C1R {ECO:0000313|Ensembl:ENSP00000438636};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000438636, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000438636, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16541075; DOI=10.1038/nature04569;
RG   Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team;
RA   Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA   Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA   Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M.,
RA   Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D.,
RA   Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z.,
RA   Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H.,
RA   Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H.,
RA   Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V.,
RA   Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J., Santibanez J.,
RA   Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A.,
RA   Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M.,
RA   Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E.,
RA   Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA   Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA   Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M.,
RA   Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R.,
RA   Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J.,
RA   Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C.,
RA   Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M.,
RA   Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M.,
RA   Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P.,
RA   Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L.,
RA   Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E.,
RA   Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C.,
RA   Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F.,
RA   Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M.,
RA   Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S.,
RA   Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA   Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA   Perrin W., Pickens A., Primus E.L., Pu L.L., Puazo M., Quiles M.M.,
RA   Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA   Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA   Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D.,
RA   Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I.,
RA   Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T.,
RA   Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S.,
RA   Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D.,
RA   Kucherlapati R., Weinstock G., Gibbs R.A., null.;
RT   "The finished DNA sequence of human chromosome 12.";
RL   Nature 440:346-351(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000438636}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
CC   -!- SIMILARITY: Belongs to the peptidase S1 family.
CC       {ECO:0000256|SAAS:SAAS00733161}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; ABBA01012193; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABBA01017671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC154092; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC233309; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEKP01126602; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEKP01126603; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; F5H2D0; -.
DR   jPOST; F5H2D0; -.
DR   PeptideAtlas; F5H2D0; -.
DR   PRIDE; F5H2D0; -.
DR   Ensembl; ENST00000535233; ENSP00000438636; ENSG00000159403.
DR   UCSC; uc010sga.3; human.
DR   EuPathDB; HostDB:ENSG00000159403.15; -.
DR   HGNC; HGNC:1246; C1R.
DR   OpenTargets; ENSG00000159403; -.
DR   GeneTree; ENSGT00940000158621; -.
DR   ChiTaRS; C1R; human.
DR   Proteomes; UP000005640; Chromosome 12.
DR   Bgee; ENSG00000159403; Expressed in 221 organ(s), highest expression level in liver.
DR   ExpressionAtlas; F5H2D0; baseline and differential.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006958; P:complement activation, classical pathway; IEA:InterPro.
DR   CDD; cd00033; CCP; 2.
DR   CDD; cd00041; CUB; 2.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   Gene3D; 2.60.120.290; -; 2.
DR   InterPro; IPR035707; Complement_C1r.
DR   InterPro; IPR000859; CUB_dom.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR   InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   PANTHER; PTHR45206; PTHR45206; 2.
DR   Pfam; PF00431; CUB; 2.
DR   Pfam; PF00084; Sushi; 2.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00032; CCP; 2.
DR   SMART; SM00042; CUB; 2.
DR   SMART; SM00181; EGF; 1.
DR   SMART; SM00179; EGF_CA; 1.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF49854; SSF49854; 2.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   SUPFAM; SSF57535; SSF57535; 2.
DR   PROSITE; PS00010; ASX_HYDROXYL; 1.
DR   PROSITE; PS01180; CUB; 2.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS01187; EGF_CA; 1.
DR   PROSITE; PS50923; SUSHI; 2.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00059,
KW   ECO:0000256|SAAS:SAAS00731840};
KW   EGF-like domain {ECO:0000256|SAAS:SAAS00032677};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00802849};
KW   Protease {ECO:0000256|SAAS:SAAS00802849};
KW   Proteomics identification {ECO:0000213|MaxQB:F5H2D0,
KW   ECO:0000213|PeptideAtlas:F5H2D0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00887150};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Sushi {ECO:0000256|PROSITE-ProRule:PRU00302,
KW   ECO:0000256|SAAS:SAAS00937752}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    671       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003327219.
FT   DOMAIN       15     78       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      159    271       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      273    339       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      340    415       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      430    668       Peptidase S1.
FT                                {ECO:0000259|PROSITE:PS50240}.
FT   DISULFID    159    186       {ECO:0000256|PROSITE-ProRule:PRU00059}.
SQ   SEQUENCE   671 AA;  76614 MW;  20D285A3F13A1AEE CRC64;
     MWLLYLLVPA LFCRAGGSIP IPQKLFGEVT SPLFPKPYPN NFETTTVITV PTGYRVKLVF
     QQFDLEPSEG CFYDYVKMLL TFHTDFSNEE NGTIMFYKGF LAYYQAVDLD ECASRSKSGE
     EDPQPQCQHL CHNYVGGYFC SCRPGYELQE DRHSCQAECS SELYTEASGY ISSLEYPRSY
     PPDLRCNYSI RVERGLTLHL KFLEPFDIDD HQQVHCPYDQ LQIYANGKNI GEFCGKQRPP
     DLDTSSNAVD LLFFTDESGD SRGWKLRYTT EIIKCPQPKT LDEFTIIQNL QPQYQFRDYF
     IATCKQGYQL IEGNQVLHSF TAVCQDDGTW HRAMPRCKIK DCGQPRNLPN GDFRYTTTMG
     VNTYKARIQY YCHEPYYKMQ TRAGSRESEQ GVYTCTAQGI WKNEQKGEKI PRCLPVCGKP
     VNPVEQRQRI IGGQKAKMGN FPWQVFTNIH GRGGGALLGD RWILTAAHTL YPKEHEAQSN
     ASLDVFLGHT NVEELMKLGN HPIRRVSVHP DYRQDESYNF EGDIALLELE NSVTLGPNLL
     PICLPDNDTF YDLGLMGYVS GFGVMEEKIA HDLRFVRLPV ANPQACENWL RGKNRMDVFS
     QNMFCAGHPS LKQDACQGDS GGVFAVRDPN TDRWVATGIV SWGIGCSRGY GFYTKVLNYV
     DWIKKEMEEE D
//