ID F5H283_HUMAN Unreviewed; 423 AA. AC F5H283; DT 28-JUN-2011, integrated into UniProtKB/TrEMBL. DT 29-OCT-2014, sequence version 2. DT 16-JAN-2019, entry version 62. DE SubName: Full=Testican-2 {ECO:0000313|Ensembl:ENSP00000439445}; GN Name=SPOCK2 {ECO:0000313|Ensembl:ENSP00000439445}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000439445, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000439445, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164054; DOI=10.1038/nature02462; RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P., RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., RA Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., RA Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., RA Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., RA Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., RA Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., RA Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., RA Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., RA Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., RA Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., RA Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., RA Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., RA Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., RA Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., RA Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., RA Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., RA Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., RA Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., RA Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T., RA Doucette-Stamm L., Beck S., Smith D.R., Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 10."; RL Nature 429:375-381(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000439445} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC022392; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F5H283; -. DR SMR; F5H283; -. DR jPOST; F5H283; -. DR PeptideAtlas; F5H283; -. DR PRIDE; F5H283; -. DR Ensembl; ENST00000536168; ENSP00000439445; ENSG00000107742. DR UCSC; uc057txb.1; human. DR EuPathDB; HostDB:ENSG00000107742.12; -. DR HGNC; HGNC:13564; SPOCK2. DR OpenTargets; ENSG00000107742; -. DR eggNOG; KOG3555; Eukaryota. DR eggNOG; ENOG410Y6A8; LUCA. DR GeneTree; ENSGT00940000157107; -. DR ChiTaRS; SPOCK2; human. DR Proteomes; UP000005640; Chromosome 10. DR Bgee; ENSG00000107742; Expressed in 210 organ(s), highest expression level in metanephric glomerulus. DR ExpressionAtlas; F5H283; baseline and differential. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR CDD; cd00191; TY; 1. DR Gene3D; 4.10.800.10; -; 1. DR InterPro; IPR011992; EF-hand-dom_pair. DR InterPro; IPR002350; Kazal_dom. DR InterPro; IPR036058; Kazal_dom_sf. DR InterPro; IPR019577; SPARC/Testican_Ca-bd-dom. DR InterPro; IPR000716; Thyroglobulin_1. DR InterPro; IPR036857; Thyroglobulin_1_sf. DR Pfam; PF07648; Kazal_2; 1. DR Pfam; PF10591; SPARC_Ca_bdg; 1. DR Pfam; PF00086; Thyroglobulin_1; 1. DR SMART; SM00280; KAZAL; 1. DR SMART; SM00211; TY; 1. DR SUPFAM; SSF100895; SSF100895; 1. DR SUPFAM; SSF47473; SSF47473; 1. DR SUPFAM; SSF57610; SSF57610; 1. DR PROSITE; PS51465; KAZAL_2; 1. DR PROSITE; PS00484; THYROGLOBULIN_1_1; 1. DR PROSITE; PS51162; THYROGLOBULIN_1_2; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00500, KW ECO:0000256|SAAS:SAAS00485231}; KW Proteomics identification {ECO:0000213|MaxQB:F5H283, KW ECO:0000213|PeptideAtlas:F5H283}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 22 {ECO:0000256|SAM:SignalP}. FT CHAIN 23 423 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003323053. FT DOMAIN 129 180 Kazal-like. FT {ECO:0000259|PROSITE:PS51465}. FT DOMAIN 309 375 Thyroglobulin type-1. FT {ECO:0000259|PROSITE:PS51162}. FT COILED 392 412 {ECO:0000256|SAM:Coils}. FT DISULFID 347 354 {ECO:0000256|PROSITE-ProRule:PRU00500}. SQ SEQUENCE 423 AA; 46649 MW; 60185CFC6C145BC4 CRC64; MRAPGCGRLV LPLLLLAAAA LAEGDAKGLK EGETPGNFME DEQWLSSISQ YSGKIKHWNR FRDVKDDYIK SWEDNQQGDE ALDTTKDPCQ KVKCSRHKVC IAQGYQRAMC ISRKKLEHRI KQPTVKLHGN KDSICKPCHM AQLASVCGSD GHTYSSVCKL EQQACLSSKQ LAVRCEGPCP CPTEQAATST ADGKPETCTG QDLADLGDRL RDWFQLLHEN SKQNGSASSV AGPASGLDKS LGASCKDSIG WMFSKLDTSA DLFLDQTELA AINLDKYEVC IRPFFNSCDT YKDGRVSTAE WCFCFWREKP PCLAELERIQ IQEAAKKKPG IFIPSCDEDG YYRKMQCDQS SGDCWCVDQL GLELTGTRTH GSPDCDDIVG FSGDFGSGVG WEDEEEKETE EAGEEAEEEE GEAGEADDGG YIW //