ID   F5H1F6_HUMAN            Unreviewed;       184 AA.
AC   F5H1F6;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   16-JAN-2019, entry version 45.
DE   SubName: Full=Vacuolar protein sorting-associated protein 37B {ECO:0000313|Ensembl:ENSP00000360294};
DE   Flags: Fragment;
GN   Name=VPS37B {ECO:0000313|Ensembl:ENSP00000360294};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000360294, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000360294, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16541075; DOI=10.1038/nature04569;
RG   Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team;
RA   Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA   Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA   Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M.,
RA   Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D.,
RA   Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z.,
RA   Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H.,
RA   Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H.,
RA   Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V.,
RA   Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J., Santibanez J.,
RA   Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A.,
RA   Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M.,
RA   Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E.,
RA   Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA   Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA   Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M.,
RA   Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R.,
RA   Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J.,
RA   Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C.,
RA   Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M.,
RA   Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M.,
RA   Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P.,
RA   Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L.,
RA   Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E.,
RA   Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C.,
RA   Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F.,
RA   Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M.,
RA   Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S.,
RA   Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA   Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA   Perrin W., Pickens A., Primus E.L., Pu L.L., Puazo M., Quiles M.M.,
RA   Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA   Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA   Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D.,
RA   Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I.,
RA   Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T.,
RA   Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S.,
RA   Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D.,
RA   Kucherlapati R., Weinstock G., Gibbs R.A., null.;
RT   "The finished DNA sequence of human chromosome 12.";
RL   Nature 440:346-351(2006).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000360294}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC027290; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; F5H1F6; -.
DR   SMR; F5H1F6; -.
DR   jPOST; F5H1F6; -.
DR   MaxQB; F5H1F6; -.
DR   PeptideAtlas; F5H1F6; -.
DR   PRIDE; F5H1F6; -.
DR   Ensembl; ENST00000371248; ENSP00000360294; ENSG00000139722.
DR   UCSC; uc058uox.1; human.
DR   EuPathDB; HostDB:ENSG00000139722.6; -.
DR   HGNC; HGNC:25754; VPS37B.
DR   OpenTargets; ENSG00000139722; -.
DR   eggNOG; KOG3270; Eukaryota.
DR   eggNOG; ENOG4111UJN; LUCA.
DR   GeneTree; ENSGT00940000153778; -.
DR   ChiTaRS; VPS37B; human.
DR   Proteomes; UP000005640; Chromosome 12.
DR   Bgee; ENSG00000139722; Expressed in 217 organ(s), highest expression level in amniotic fluid.
DR   ExpressionAtlas; F5H1F6; baseline and differential.
DR   GO; GO:0000813; C:ESCRT I complex; IEA:InterPro.
DR   GO; GO:0032509; P:endosome transport via multivesicular body sorting pathway; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.287.660; -; 1.
DR   InterPro; IPR037202; ESCRT_assembly_dom.
DR   InterPro; IPR029012; Helix_hairpin_bin_sf.
DR   InterPro; IPR009851; Mod_r.
DR   InterPro; IPR037859; Vps37.
DR   PANTHER; PTHR13678; PTHR13678; 1.
DR   Pfam; PF07200; Mod_r; 1.
DR   SUPFAM; SSF140111; SSF140111; 1.
DR   PROSITE; PS51314; VPS37_C; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Protein transport {ECO:0000256|PROSITE-ProRule:PRU00646};
KW   Proteomics identification {ECO:0000213|EPD:F5H1F6,
KW   ECO:0000213|MaxQB:F5H1F6, ECO:0000213|PeptideAtlas:F5H1F6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transport {ECO:0000256|PROSITE-ProRule:PRU00646}.
FT   SIGNAL        1     31       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        32    184       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003327213.
FT   DOMAIN       82    171       VPS37 C-terminal.
FT                                {ECO:0000259|PROSITE:PS51314}.
FT   COILED       68     88       {ECO:0000256|SAM:Coils}.
FT   NON_TER     184    184       {ECO:0000313|Ensembl:ENSP00000360294}.
SQ   SEQUENCE   184 AA;  20654 MW;  4F6A5449AD985DCE CRC64;
     MQSGCVLELR NAGLVACLAL ITVFVAECCY GDSCQTQNVQ LNKEMTLASN RSLAEGNLLY
     QPQLDTLKAR LTQKYQELQV LFEAYQIKKT KLDRQSSSAS LETLLALLQA EGAKIEEDTE
     NMAEKFLDGE LPLDSFIDVY QSKRKLAHMR RVKIEKLQEM VLKGQRLPQA LAPLPPRLPE
     LAPT
//