ID   F5H116_HUMAN            Unreviewed;       203 AA.
AC   F5H116;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   05-DEC-2018, entry version 51.
DE   SubName: Full=Piwi-like protein 4 {ECO:0000313|Ensembl:ENSP00000439710};
GN   Name=PIWIL4 {ECO:0000313|Ensembl:ENSP00000439710};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000439710, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000439710, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000439710}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AP000943; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455451; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; F5H116; -.
DR   SMR; F5H116; -.
DR   PeptideAtlas; F5H116; -.
DR   PRIDE; F5H116; -.
DR   Ensembl; ENST00000537419; ENSP00000439710; ENSG00000134627.
DR   UCSC; uc058gpt.1; human.
DR   EuPathDB; HostDB:ENSG00000134627.11; -.
DR   HGNC; HGNC:18444; PIWIL4.
DR   OpenTargets; ENSG00000134627; -.
DR   eggNOG; KOG1042; Eukaryota.
DR   eggNOG; ENOG410XNRH; LUCA.
DR   GeneTree; ENSGT00940000154093; -.
DR   ChiTaRS; PIWIL4; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000134627; Expressed in 170 organ(s), highest expression level in bone marrow.
DR   ExpressionAtlas; F5H116; baseline and differential.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR003165; Piwi.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF02171; Piwi; 1.
DR   SMART; SM00950; Piwi; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS50822; PIWI; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:F5H116,
KW   ECO:0000213|PeptideAtlas:F5H116};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    203       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003327553.
FT   DOMAIN       36    189       Piwi. {ECO:0000259|PROSITE:PS50822}.
SQ   SEQUENCE   203 AA;  23203 MW;  A6E5F3E0793175CA CRC64;
     MGMLFFVGIR KVILFLLTPN SAGALNKWYK YNHDLPARII VYRAGVGDGQ LKTLIEYEVP
     QLLSSVAESS SNTSSRLSVI VVRKKCMPRF FTEMNRTVQN PPLGTVVDSE ATRNEWYDFY
     LISQVACRGT VSPTYYNVIY DDNGLKPDHM QRLTFKLCHL YYNWPGIVSV PAPCQYAHKL
     TFLVAQSIHK EPSLELANHL FYL
//