ID   F5H107_HUMAN            Unreviewed;      1260 AA.
AC   F5H107;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 2.
DT   16-JAN-2019, entry version 68.
DE   SubName: Full=Contactin-associated protein-like 4 {ECO:0000313|Ensembl:ENSP00000439733};
GN   Name=CNTNAP4 {ECO:0000313|Ensembl:ENSP00000439733};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000439733, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000439733, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA   Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA   Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA   Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA   Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA   Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA   Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA   Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA   Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA   Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA   Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA   Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA   Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA   Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA   Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA   Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA   Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA   Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA   Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA   Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA   Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000439733}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR   EMBL; AC010528; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC106741; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; FO681478; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; F5H107; -.
DR   jPOST; F5H107; -.
DR   PeptideAtlas; F5H107; -.
DR   PRIDE; F5H107; -.
DR   Ensembl; ENST00000377504; ENSP00000439733; ENSG00000152910.
DR   UCSC; uc059xie.1; human.
DR   EuPathDB; HostDB:ENSG00000152910.18; -.
DR   HGNC; HGNC:18747; CNTNAP4.
DR   OpenTargets; ENSG00000152910; -.
DR   eggNOG; KOG3516; Eukaryota.
DR   eggNOG; ENOG410XPHG; LUCA.
DR   GeneTree; ENSGT00940000157674; -.
DR   ChiTaRS; CNTNAP4; human.
DR   Proteomes; UP000005640; Chromosome 16.
DR   Bgee; ENSG00000152910; Expressed in 96 organ(s), highest expression level in C1 segment of cervical spinal cord.
DR   ExpressionAtlas; F5H107; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   CDD; cd00057; FA58C; 1.
DR   Gene3D; 2.60.120.260; -; 1.
DR   InterPro; IPR028875; CASPR4.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000421; FA58C.
DR   InterPro; IPR036056; Fibrinogen-like_C.
DR   InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR001791; Laminin_G.
DR   PANTHER; PTHR43925:SF2; PTHR43925:SF2; 2.
DR   Pfam; PF00754; F5_F8_type_C; 1.
DR   Pfam; PF02210; Laminin_G_2; 4.
DR   SMART; SM00181; EGF; 2.
DR   SMART; SM00231; FA58C; 1.
DR   SMART; SM00282; LamG; 4.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF49899; SSF49899; 4.
DR   SUPFAM; SSF56496; SSF56496; 1.
DR   PROSITE; PS50026; EGF_3; 2.
DR   PROSITE; PS01285; FA58C_1; 1.
DR   PROSITE; PS01286; FA58C_2; 1.
DR   PROSITE; PS50022; FA58C_3; 1.
DR   PROSITE; PS51406; FIBRINOGEN_C_2; 1.
DR   PROSITE; PS50025; LAM_G_DOMAIN; 3.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00122,
KW   ECO:0000256|SAAS:SAAS00814887};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:F5H107};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00966518};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26   1260       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003324722.
FT   TRANSMEM   1193   1217       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       31    177       F5/8 type C.
FT                                {ECO:0000259|PROSITE:PS50022}.
FT   DOMAIN      322    499       LAM_G_DOMAIN.
FT                                {ECO:0000259|PROSITE:PS50025}.
FT   DOMAIN      501    538       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      537    588       Fibrinogen C-terminal.
FT                                {ECO:0000259|PROSITE:PS51406}.
FT   DOMAIN      745    910       LAM_G_DOMAIN.
FT                                {ECO:0000259|PROSITE:PS50025}.
FT   DOMAIN      911    949       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      961   1154       LAM_G_DOMAIN.
FT                                {ECO:0000259|PROSITE:PS50025}.
FT   DISULFID    883    910       {ECO:0000256|PROSITE-ProRule:PRU00122}.
SQ   SEQUENCE   1260 AA;  140034 MW;  7274B5843731AE70 CRC64;
     MGSVTGAVLK TLLLLSTQNW NRVEAGNSYD CDDPLVSALP QASFSSSSEL SSSHGPGFAR
     LNRRDGAGGW SPLVSNKYQW LQIDLGERME VTAVATQGGY GSSNWVTSYL LMFSDSGWNW
     KQYRQEDSIW GFSGNANADS VVYYRLQPSI KARFLRFIPL EWNPKGRIGM RIEVFGCAYR
     SEVVDLDGKS SLLYRFDQKS LSPIKDIISL KFKTMQSDGI LLHREGPNGD HITLQLRRAR
     LFLLINSGEA KLPSTSTLVN LTLGSLLDDQ HWHSVLIQRL GKQVNFTVDE HRHHFHARGE
     FNLMNLDYEG NVSFSCSQPQ SMPVTFLSSR SYLALPDFSG EEEVSATFQF RTWNKAGLLL
     FSELQLISGG ILLFLSDGKL KSNLYQPGKL PSDITAGVEL NDGQWHSVSL SAKKNHLSVA
     VDGQMASAAP LLGPEQIYSG GTYYFGGCPD KSFGSKCKSP LGGFQGCMRL ISISGKVVDL
     ISVQQGSLGN FSDLQIDSCG ISDRCLPNYC EHGGECSQSW STFHCNCTNT GYRGATCHNS
     IYEQSCEAYK HRGNTSGFYY IDSDGSGPLE PFLLYCNMTE TAWTIIQHNG SDLTRVRNTN
     PENPYAGFFE YVASMEQLQA TINRAEHCEQ EFTYYCKKSR LVNKQDGTPL SWWVGRTNET
     QTYWGGSSPD LQKCTCGLEG NCIDSQYYCN CDADRNEWTN DTGLLAYKEH LPVTKIVITD
     TGRLHSEAAY KLGPLLCQGD RSFWNSASFD TEASYLHFPT FHGELSADVS FFFKTTASSG
     VFLENLGIAD FIRIELRSPT VVTFSFDVGN GPFEISVQSP THFNDNQWHH VRVERNMKEA
     SLQVDQLTPK TQPAPADGHV LLQLNSQLFV GGTATRQRGF LGCIRSLQLN GMTLDLEERA
     QVTPEVQPGC RGHCSSYGKL CRNGGKCRER PIGFFCDCTF SAYTGPFCSN EISAYFGSGS
     SVIYNFQENY LLSKNSSSHA ASFHGDMKLS REMIKFSFRT TRTPSLLLFV SSFYKEYLSV
     IIAKNGDLQI RYKLNKYQEP DVVNFDFKNM ADGQLHHIMI NREEGVVFIE IDDNRRRQVH
     LSSGTEFSAV KSLVLGRILE HSDVDQDTAL AGAQGFTGCL SAVQLSHVAP LKAALHPSHP
     DPVTVTGHVT ESSCMAQPGT DATSRERTHS FADHSGTIDD REPLANAIKS DSAVIGGLIA
     VVIFILLCIT AIAVRIYQQK RLYKRSEAKR SENVDSAEAV LKSELNIQNA VNENQKEYFF
//