ID   F5H0V4_HUMAN            Unreviewed;       308 AA.
AC   F5H0V4;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   16-JAN-2019, entry version 53.
DE   SubName: Full=MLX-interacting protein {ECO:0000313|Ensembl:ENSP00000445891};
DE   Flags: Fragment;
GN   Name=MLXIP {ECO:0000313|Ensembl:ENSP00000445891};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000445891, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000445891, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16541075; DOI=10.1038/nature04569;
RG   Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team;
RA   Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA   Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA   Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M.,
RA   Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D.,
RA   Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z.,
RA   Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H.,
RA   Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H.,
RA   Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V.,
RA   Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J., Santibanez J.,
RA   Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A.,
RA   Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M.,
RA   Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E.,
RA   Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA   Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA   Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M.,
RA   Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R.,
RA   Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J.,
RA   Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C.,
RA   Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M.,
RA   Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M.,
RA   Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P.,
RA   Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L.,
RA   Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E.,
RA   Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C.,
RA   Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F.,
RA   Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M.,
RA   Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S.,
RA   Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA   Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA   Perrin W., Pickens A., Primus E.L., Pu L.L., Puazo M., Quiles M.M.,
RA   Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA   Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA   Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D.,
RA   Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I.,
RA   Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T.,
RA   Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S.,
RA   Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D.,
RA   Kucherlapati R., Weinstock G., Gibbs R.A., null.;
RT   "The finished DNA sequence of human chromosome 12.";
RL   Nature 440:346-351(2006).
RN   [2] {ECO:0000213|PubMed:19413330}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19413330; DOI=10.1021/ac9004309;
RA   Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA   Mohammed S.;
RT   "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT   a refined SCX-based approach.";
RL   Anal. Chem. 81:4493-4501(2009).
RN   [3] {ECO:0000313|Ensembl:ENSP00000445891}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:23186163}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23186163;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
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DR   EMBL; ABBA01020202; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABBA01060482; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC048338; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC130894; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC156455; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC190384; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC205581; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEKP01164321; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; F5H0V4; -.
DR   jPOST; F5H0V4; -.
DR   MaxQB; F5H0V4; -.
DR   PRIDE; F5H0V4; -.
DR   Ensembl; ENST00000366272; ENSP00000445891; ENSG00000175727.
DR   UCSC; uc058ukv.1; human.
DR   EuPathDB; HostDB:ENSG00000175727.13; -.
DR   HGNC; HGNC:17055; MLXIP.
DR   OpenTargets; ENSG00000175727; -.
DR   eggNOG; KOG3582; Eukaryota.
DR   eggNOG; ENOG410XTA5; LUCA.
DR   GeneTree; ENSGT00940000158691; -.
DR   ChiTaRS; MLXIP; human.
DR   Proteomes; UP000005640; Chromosome 12.
DR   Bgee; ENSG00000175727; Expressed in 222 organ(s), highest expression level in caecum.
DR   ExpressionAtlas; F5H0V4; baseline and differential.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:1900402; P:regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter; IEA:InterPro.
DR   CDD; cd00083; HLH; 1.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR032648; MLXIP.
DR   PANTHER; PTHR15741:SF23; PTHR15741:SF23; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:F5H0V4,
KW   ECO:0000213|PeptideAtlas:F5H0V4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18    308       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003327551.
FT   DOMAIN      190    240       BHLH. {ECO:0000259|PROSITE:PS50888}.
FT   COILED      237    271       {ECO:0000256|SAM:Coils}.
FT   NON_TER     308    308       {ECO:0000313|Ensembl:ENSP00000445891}.
SQ   SEQUENCE   308 AA;  33258 MW;  B57BD97A6F4CDA7A CRC64;
     MVLGALVALS SCPLGLRTSC LTGREAASAG WARPCGPGLH LNILLILAAA FSGQPQAVIM
     TSGPLKREGM LASTVSQSNV VIAPAAIARA PGVPEFHSSI LVTDLGHGTS SPPAPVSRLF
     PSTAQDPLGK GEQVPLHGGS PQVTVTGPSR DCPNSGQASP CASEQSPSPQ SPQNNCSGKS
     DPKNVAALKN RQMKHISAEQ KRRFNIKMCF DMLNSLISNN SKLTSHAITL QKTVEYITKL
     QQERGQMQEE ARRLREEIEE LNATIISCQQ LLPATGVPVT RRQFDHMKDM FDEYVKTRTL
     QNWKFWIV
//