ID F5GZZ9_HUMAN Unreviewed; 1109 AA. AC F5GZZ9; DT 28-JUN-2011, integrated into UniProtKB/TrEMBL. DT 28-JUN-2011, sequence version 1. DT 16-JAN-2019, entry version 56. DE SubName: Full=Scavenger receptor cysteine-rich type 1 protein M130 {ECO:0000313|Ensembl:ENSP00000444071}; GN Name=CD163 {ECO:0000313|Ensembl:ENSP00000444071}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000444071, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000444071, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16541075; DOI=10.1038/nature04569; RG Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team; RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., RA Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., RA Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., RA Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., RA Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., RA Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., RA Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., RA Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., RA Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., RA Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J., Santibanez J., RA Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., RA Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., RA Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., RA Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., RA Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., RA Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., RA Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., RA Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., RA Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., RA Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., RA Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., RA Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., RA Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., RA Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., RA Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., RA Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., RA Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., RA Perrin W., Pickens A., Primus E.L., Pu L.L., Puazo M., Quiles M.M., RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., RA Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., RA Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., RA Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., RA Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., RA Kucherlapati R., Weinstock G., Gibbs R.A., null.; RT "The finished DNA sequence of human chromosome 12."; RL Nature 440:346-351(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000444071} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [3] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC131206; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F5GZZ9; -. DR jPOST; F5GZZ9; -. DR PRIDE; F5GZZ9; -. DR Ensembl; ENST00000541972; ENSP00000444071; ENSG00000177575. DR UCSC; uc058kto.1; human. DR EuPathDB; HostDB:ENSG00000177575.12; -. DR HGNC; HGNC:1631; CD163. DR OpenTargets; ENSG00000177575; -. DR eggNOG; ENOG410IHBC; Eukaryota. DR eggNOG; ENOG410XQVR; LUCA. DR GeneTree; ENSGT00940000155987; -. DR ChiTaRS; CD163; human. DR Proteomes; UP000005640; Chromosome 12. DR Bgee; ENSG00000177575; Expressed in 190 organ(s), highest expression level in esophagus. DR ExpressionAtlas; F5GZZ9; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro. DR Gene3D; 3.10.250.10; -; 9. DR InterPro; IPR001190; SRCR. DR InterPro; IPR017448; SRCR-like_dom. DR InterPro; IPR036772; SRCR-like_dom_sf. DR Pfam; PF00530; SRCR; 9. DR PRINTS; PR00258; SPERACTRCPTR. DR SMART; SM00202; SR; 9. DR SUPFAM; SSF56487; SSF56487; 9. DR PROSITE; PS00420; SRCR_1; 4. DR PROSITE; PS50287; SRCR_2; 9. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00196, KW ECO:0000256|SAAS:SAAS00873970}; Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:F5GZZ9, KW ECO:0000213|PeptideAtlas:F5GZZ9}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 33 {ECO:0000256|SAM:SignalP}. FT CHAIN 34 1109 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003323000. FT TRANSMEM 1039 1059 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 39 140 SRCR. {ECO:0000259|PROSITE:PS50287}. FT DOMAIN 147 247 SRCR. {ECO:0000259|PROSITE:PS50287}. FT DOMAIN 254 354 SRCR. {ECO:0000259|PROSITE:PS50287}. FT DOMAIN 361 461 SRCR. {ECO:0000259|PROSITE:PS50287}. FT DOMAIN 466 566 SRCR. {ECO:0000259|PROSITE:PS50287}. FT DOMAIN 571 671 SRCR. {ECO:0000259|PROSITE:PS50287}. FT DOMAIN 707 807 SRCR. {ECO:0000259|PROSITE:PS50287}. FT DOMAIN 812 914 SRCR. {ECO:0000259|PROSITE:PS50287}. FT DOMAIN 917 1017 SRCR. {ECO:0000259|PROSITE:PS50287}. FT DISULFID 108 118 {ECO:0000256|PROSITE-ProRule:PRU00196}. FT DISULFID 172 236 {ECO:0000256|PROSITE-ProRule:PRU00196}. FT DISULFID 185 246 {ECO:0000256|PROSITE-ProRule:PRU00196}. FT DISULFID 216 226 {ECO:0000256|PROSITE-ProRule:PRU00196}. FT DISULFID 279 343 {ECO:0000256|PROSITE-ProRule:PRU00196}. FT DISULFID 292 353 {ECO:0000256|PROSITE-ProRule:PRU00196}. FT DISULFID 323 333 {ECO:0000256|PROSITE-ProRule:PRU00196}. FT DISULFID 386 450 {ECO:0000256|PROSITE-ProRule:PRU00196}. FT DISULFID 399 460 {ECO:0000256|PROSITE-ProRule:PRU00196}. FT DISULFID 430 440 {ECO:0000256|PROSITE-ProRule:PRU00196}. FT DISULFID 491 555 {ECO:0000256|PROSITE-ProRule:PRU00196}. FT DISULFID 504 565 {ECO:0000256|PROSITE-ProRule:PRU00196}. FT DISULFID 535 545 {ECO:0000256|PROSITE-ProRule:PRU00196}. FT DISULFID 596 660 {ECO:0000256|PROSITE-ProRule:PRU00196}. FT DISULFID 609 670 {ECO:0000256|PROSITE-ProRule:PRU00196}. FT DISULFID 640 650 {ECO:0000256|PROSITE-ProRule:PRU00196}. FT DISULFID 732 796 {ECO:0000256|PROSITE-ProRule:PRU00196}. FT DISULFID 745 806 {ECO:0000256|PROSITE-ProRule:PRU00196}. FT DISULFID 776 786 {ECO:0000256|PROSITE-ProRule:PRU00196}. FT DISULFID 839 903 {ECO:0000256|PROSITE-ProRule:PRU00196}. FT DISULFID 852 913 {ECO:0000256|PROSITE-ProRule:PRU00196}. FT DISULFID 883 893 {ECO:0000256|PROSITE-ProRule:PRU00196}. FT DISULFID 942 1006 {ECO:0000256|PROSITE-ProRule:PRU00196}. FT DISULFID 955 1016 {ECO:0000256|PROSITE-ProRule:PRU00196}. FT DISULFID 986 996 {ECO:0000256|PROSITE-ProRule:PRU00196}. SQ SEQUENCE 1109 AA; 120322 MW; 50B73BFE15FD32EA CRC64; MSLDFRRHFV NLSPFTITVV LLLSACFVTS SLGGTDKELR LVDGENKCSG RVEVKVQEEW GTVCNNGWSM EAVSVICNQL GCPTAIKAPG WANSSAGSGR IWMDHVSCRG NESALWDCKH DGWGKHSNCT HQQDAGVTCS DGSNLEMRLT RGGNMCSGRI EIKFQGRWGT VCDDNFNIDH ASVICRQLEC GSAVSFSGSS NFGEGSGPIW FDDLICNGNE SALWNCKHQG WGKHNCDHAE DAGVICSKGA DLSLRLVDGV TECSGRLEVR FQGEWGTICD DGWDSYDAAV ACKQLGCPTA VTAIGRVNAS KGFGHIWLDS VSCQGHEPAI WQCKHHEWGK HYCNHNEDAG VTCSDGSDLE LRLRGGGSRC AGTVEVEIQR LLGKVCDRGW GLKEADVVCR QLGCGSALKT SYQVYSKIQA TNTWLFLSSC NGNETSLWDC KNWQWGGLTC DHYEEAKITC SAHREPRLVG GDIPCSGRVE VKHGDTWGSI CDSDFSLEAA SVLCRELQCG TVVSILGGAH FGEGNGQIWA EEFQCEGHES HLSLCPVAPR PEGTCSHSRD VGVVCSRYTE IRLVNGKTPC EGRVELKTLG AWGSLCNSHW DIEDAHVLCQ QLKCGVALST PGGARFGKGN GQIWRHMFHC TGTEQHMGDC PVTALGASLC PSEQVASVIC SGNQSQTLSS CNSSSLGPTR PTIPEESAVA CIESGQLRLV NGGGRCAGRV EIYHEGSWGT ICDDSWDLSD AHVVCRQLGC GEAINATGSA HFGEGTGPIW LDEMKCNGKE SRIWQCHSHG WGQQNCRHKE DAGVICSEFM SLRLTSEASR EACAGRLEVF YNGAWGTVGK SSMSETTVGV VCRQLGCADK GKINPASLDK AMSIPMWVDN VQCPKGPDTL WQCPSSPWEK RLASPSEETW ITCDNKIRLQ EGPTSCSGRV EIWHGGSWGT VCDDSWDLDD AQVVCQQLGC GPALKAFKEA EFGQGTGPIW LNEVKCKGNE SSLWDCPARR WGHSECGHKE DAAVNCTDIS VQKTPQKATT GRSSRQSSFI AVGILGVVLL AIFVALFFLT KKRRQRQRLA VSSRGENLVH QIQYREMNSC LNADDLDLMN SSGGHSEPH //