ID   F5GZZ5_HUMAN            Unreviewed;       149 AA.
AC   F5GZZ5;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   05-DEC-2018, entry version 49.
DE   SubName: Full=Ephrin type-A receptor 4 {ECO:0000313|Ensembl:ENSP00000444085};
DE   Flags: Fragment;
GN   Name=EPHA4 {ECO:0000313|Ensembl:ENSP00000444085};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000444085, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000444085, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000444085}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC010899; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC079834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PeptideAtlas; F5GZZ5; -.
DR   PRIDE; F5GZZ5; -.
DR   Ensembl; ENST00000541600; ENSP00000444085; ENSG00000116106.
DR   UCSC; uc061tbd.1; human.
DR   EuPathDB; HostDB:ENSG00000116106.11; -.
DR   HGNC; HGNC:3388; EPHA4.
DR   OpenTargets; ENSG00000116106; -.
DR   eggNOG; KOG0196; Eukaryota.
DR   eggNOG; COG0515; LUCA.
DR   GeneTree; ENSGT00940000156948; -.
DR   ChiTaRS; EPHA4; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000116106; Expressed in 211 organ(s), highest expression level in forebrain.
DR   ExpressionAtlas; F5GZZ5; baseline and differential.
DR   Gene3D; 2.60.120.260; -; 1.
DR   InterPro; IPR001090; Ephrin_rcpt_lig-bd_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   Pfam; PF01404; Ephrin_lbd; 1.
DR   SMART; SM00615; EPH_lbd; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   PROSITE; PS51550; EPH_LBD; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:F5GZZ5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    149       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003327542.
FT   DOMAIN       30    149       Eph LBD. {ECO:0000259|PROSITE:PS51550}.
FT   NON_TER     149    149       {ECO:0000313|Ensembl:ENSP00000444085}.
SQ   SEQUENCE   149 AA;  17152 MW;  A268980A0D6DB7A7 CRC64;
     MAGIFYFALF SCLFGICDAV TGSRVYPANE VTLLDSRSVQ GELGWIASPL EGGWEEVSIM
     DEKNTPIRTY QVCNVMEPSQ NNWLRTDWIT REGAQRVYIE IKFTLRDCNS LPGVMGTCKE
     TFNLYYYESD NDKERFIREN QFVKIDTIA
//