ID   F5GZK2_HUMAN            Unreviewed;       956 AA.
AC   F5GZK2;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 2.
DT   16-JAN-2019, entry version 59.
DE   SubName: Full=Collagen alpha-1(XXI) chain {ECO:0000313|Ensembl:ENSP00000444384};
GN   Name=COL21A1 {ECO:0000313|Ensembl:ENSP00000444384};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000444384, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000444384, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA   Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA   Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA   Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA   Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA   Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA   Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA   Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA   Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA   Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA   Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA   Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA   McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA   Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA   Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA   Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA   Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA   Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA   Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA   Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA   Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA   Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000444384}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AL031779; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL031782; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL034452; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL450430; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL513530; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL590675; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; F5GZK2; -.
DR   EPD; F5GZK2; -.
DR   jPOST; F5GZK2; -.
DR   PeptideAtlas; F5GZK2; -.
DR   PRIDE; F5GZK2; -.
DR   Ensembl; ENST00000535941; ENSP00000444384; ENSG00000124749.
DR   UCSC; uc063peb.1; human.
DR   EuPathDB; HostDB:ENSG00000124749.16; -.
DR   HGNC; HGNC:17025; COL21A1.
DR   OpenTargets; ENSG00000124749; -.
DR   eggNOG; ENOG410IS78; Eukaryota.
DR   eggNOG; ENOG41100RI; LUCA.
DR   GeneTree; ENSGT00940000162318; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   Bgee; ENSG00000124749; Expressed in 192 organ(s), highest expression level in metanephros.
DR   ExpressionAtlas; F5GZK2; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IDA:HPA.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR008160; Collagen.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   Pfam; PF01391; Collagen; 7.
DR   Pfam; PF00092; VWA; 1.
DR   SMART; SM00210; TSPN; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:F5GZK2,
KW   ECO:0000213|PeptideAtlas:F5GZK2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    956       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003324715.
FT   DOMAIN       37    211       VWFA. {ECO:0000259|PROSITE:PS50234}.
SQ   SEQUENCE   956 AA;  99296 MW;  D13685F4BFA0AEF1 CRC64;
     MAHYITFLCM VLVLLLQNSV LAEDGEVRSS CRTAPTDLVF ILDGSYSVGP ENFEIVKKWL
     VNITKNFDIG PKFIQVGVVQ YSDYPVLEIP LGSYDSGEHL TAAVESILYL GGNTKTGKAI
     QFALDYLFAK SSRFLTKIAV VLTDGKSQDD VKDAAQAARD SKITLFAIGV GSETEDAELR
     AIANKPSSTY VFYVEDYIAI SKIREVMKQK LCEESVCPTR IPVAARDERG FDILLGLDVN
     KKVKKRIQLS PKKIKGYEVT SKVDLSELTS NVFPEGLPPS YVFVSTQRFK VKKIWDLWRI
     LTIDGRPQIA VTLNGVDKIL LFTTTSVING SQVVTFANPQ VKTLFDEGWH QIRLLVTEQD
     VTLYIDDQQI ENKPLHPVLG ILINGQTQIG KYSGKEETVQ FDVQKLRIYC DPEQNNRETA
     CEIPGFVKCL NGPSDVGSTP APCICPPGKP GLQGPKGDPG LPGNPGYPGQ PGQDGKPGYQ
     GIAGTPGVPG SPGIQGARGL PGYKGEPGRD GDKGDRGLPG FPGLHGMPGS KGEMGAKGDK
     GSPGFYGKKG AKGEKGNAGF PGLPGPAGEP GRHGKDGLMG SPGFKGEAGS PGAPGQDGTR
     GEPGIPGFPG NRGLMGQKGE IGPPGQQGKK GAPGMPGLMG SNGSPGQPGT PGSKGSKGEP
     GIQGMPGASG LKGEPGATGS PGEPGYMGLP GIQGKKGDKG NQGEKGIQGQ KGENGRQGIP
     GQQGIQGHHG AKGERGEKGE PGVRGAIGSK GESGVDGLMG PAGPKGQPGD PGPQGPPGLD
     GKPGREFSEQ FIRQVCTDVI RAQLPVLLQS GRIRNCDHCL SQHGSPGIPG PPGPIGPEGP
     RGLPGLPGRD GVPGLVGVPG RPGVRGLKGL PGRNGEKGSQ GFGYPGEQGP PGPPGPEGPP
     GISKEGPPGD PGLPGKDGDH GKPGIQGQPG PPGICDPSLC FSVIARRDPF RKGPNY
//