ID   F5GZ45_HUMAN            Unreviewed;       180 AA.
AC   F5GZ45;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 8.
DT   16-JAN-2019, entry version 55.
DE   SubName: Full=Folate receptor beta {ECO:0000313|Ensembl:ENSP00000441547};
DE   Flags: Fragment;
GN   Name=FOLR2 {ECO:0000313|Ensembl:ENSP00000441547};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000441547, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000441547, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000441547}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AP000593; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455414; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; F5GZ45; -.
DR   SMR; F5GZ45; -.
DR   jPOST; F5GZ45; -.
DR   PeptideAtlas; F5GZ45; -.
DR   PRIDE; F5GZ45; -.
DR   Ensembl; ENST00000539412; ENSP00000441547; ENSG00000165457.
DR   UCSC; uc058fac.1; human.
DR   EuPathDB; HostDB:ENSG00000165457.13; -.
DR   HGNC; HGNC:3793; FOLR2.
DR   OpenTargets; ENSG00000165457; -.
DR   eggNOG; ENOG410IFFP; Eukaryota.
DR   eggNOG; ENOG4111IU4; LUCA.
DR   GeneTree; ENSGT00940000153758; -.
DR   ChiTaRS; FOLR2; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000165457; Expressed in 215 organ(s), highest expression level in esophagus.
DR   ExpressionAtlas; F5GZ45; baseline and differential.
DR   GO; GO:0005542; F:folic acid binding; IEA:InterPro.
DR   GO; GO:0061714; F:folic acid receptor activity; IEA:InterPro.
DR   GO; GO:1904447; P:folate import across plasma membrane; IEA:InterPro.
DR   InterPro; IPR004269; Folate_rcpt.
DR   InterPro; IPR018143; Folate_rcpt-like.
DR   InterPro; IPR032937; FOLR2.
DR   PANTHER; PTHR10517; PTHR10517; 1.
DR   PANTHER; PTHR10517:SF8; PTHR10517:SF8; 1.
DR   Pfam; PF03024; Folate_rec; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:F5GZ45,
KW   ECO:0000213|PeptideAtlas:F5GZ45};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     32       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        33    180       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5008414316.
FT   DOMAIN       41    180       Folate_rec. {ECO:0000259|Pfam:PF03024}.
FT   NON_TER     180    180       {ECO:0000313|Ensembl:ENSP00000441547}.
SQ   SEQUENCE   180 AA;  20912 MW;  F320CF7FDAD61B24 CRC64;
     MLPAATEGQK DMVWKWMPLL LLLVCVATMC SAQDRTDLLN VCMDAKHHKT KPGPEDKLHD
     QCSPWKKNAC CTASTSQELH KDTSRLYNFN WDHCGKMEPA CKRHFIQDTC LYECSPNLGP
     WIQQVNQSWR KERFLDVPLC KEDCQRWWED CHTSHTCKSN WHRGWDWTSG VNKCPAGALC
//