ID   F5GZ43_HUMAN            Unreviewed;       381 AA.
AC   F5GZ43;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   16-JAN-2019, entry version 59.
DE   SubName: Full=Probable G-protein-coupled receptor 83 {ECO:0000313|Ensembl:ENSP00000441550};
GN   Name=GPR83 {ECO:0000313|Ensembl:ENSP00000441550};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000441550, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000441550, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000441550}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AP000765; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001317274.1; NM_001330345.1.
DR   UniGene; Hs.272385; -.
DR   ProteinModelPortal; F5GZ43; -.
DR   PeptideAtlas; F5GZ43; -.
DR   PRIDE; F5GZ43; -.
DR   Ensembl; ENST00000539203; ENSP00000441550; ENSG00000123901.
DR   GeneID; 10888; -.
DR   UCSC; uc058gow.1; human.
DR   CTD; 10888; -.
DR   EuPathDB; HostDB:ENSG00000123901.8; -.
DR   HGNC; HGNC:4523; GPR83.
DR   OpenTargets; ENSG00000123901; -.
DR   GeneTree; ENSGT00940000154336; -.
DR   OrthoDB; 1254727at2759; -.
DR   GenomeRNAi; 10888; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000123901; Expressed in 72 organ(s), highest expression level in cerebellar vermis.
DR   ExpressionAtlas; F5GZ43; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     16       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        17    381       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003322991.
FT   TRANSMEM     70     97       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    109    132       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    144    164       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    199    220       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    251    272       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    284    306       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       87    303       G_PROTEIN_RECEP_F1_2.
FT                                {ECO:0000259|PROSITE:PS50262}.
SQ   SEQUENCE   381 AA;  43606 MW;  26081476680C969F CRC64;
     MVPHLLLLCL LPLVRATEPH EGRADEQSAE AALAVPNASH FFSWNNYTFS DWQNFVGRRR
     YGAESQNPTV KALLIVAYSF IIVFSLFGNV LVCHVIFKNQ RMHSATSLFI VNLAVADIMI
     TLLNTPFTLV IMHPLKPRIS ITKGVIYIAV IWTMATFFSL PHAICQKLFT FKYSEDIVRS
     LCLPDFPEPA DLFWKYLDLA TFILLYILPL LIISVAYARV AKKLWLCNMI GDVTTEQYFA
     LRRKKKKTIK MLMLVVVLFA LCWFPLNCYV LLLSSKVIRT NNALYFAFHW FAMSSTCYNP
     FIYCWLNENF RIELKALLSM CQRPPKPQED RPPSPVPSFR VAWTEKNDGQ RAPLANNLLP
     TSQLQSGKTD LSSVEPIVTM S
//