ID   F5GYX7_HUMAN            Unreviewed;       181 AA.
AC   F5GYX7;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   16-JAN-2019, entry version 56.
DE   SubName: Full=Stromelysin-2 {ECO:0000313|Ensembl:ENSP00000441485};
DE   Flags: Fragment;
GN   Name=MMP10 {ECO:0000313|Ensembl:ENSP00000441485};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000441485, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000441485, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000441485}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AP000619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; F5GYX7; -.
DR   jPOST; F5GYX7; -.
DR   PeptideAtlas; F5GYX7; -.
DR   PRIDE; F5GYX7; -.
DR   Ensembl; ENST00000539681; ENSP00000441485; ENSG00000166670.
DR   UCSC; uc058gwd.1; human.
DR   EuPathDB; HostDB:ENSG00000166670.9; -.
DR   HGNC; HGNC:7156; MMP10.
DR   OpenTargets; ENSG00000166670; -.
DR   GeneTree; ENSGT00940000163375; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000166670; Expressed in 79 organ(s), highest expression level in nasal cavity epithelium.
DR   ExpressionAtlas; F5GYX7; baseline and differential.
DR   GO; GO:0031012; C:extracellular matrix; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 1.10.101.10; -; 1.
DR   Gene3D; 3.40.390.10; -; 1.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR001818; Pept_M10_metallopeptidase.
DR   InterPro; IPR021190; Pept_M10A.
DR   InterPro; IPR021158; Pept_M10A_Zn_BS.
DR   InterPro; IPR002477; Peptidoglycan-bd-like.
DR   InterPro; IPR036365; PGBD-like_sf.
DR   InterPro; IPR036366; PGBDSf.
DR   Pfam; PF00413; Peptidase_M10; 1.
DR   Pfam; PF01471; PG_binding_1; 1.
DR   PRINTS; PR00138; MATRIXIN.
DR   SUPFAM; SSF47090; SSF47090; 1.
DR   PROSITE; PS00546; CYSTEINE_SWITCH; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:F5GYX7,
KW   ECO:0000213|PeptideAtlas:F5GYX7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18    181       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5017483787.
FT   DOMAIN       33     86       PG_binding_1. {ECO:0000259|Pfam:PF01471}.
FT   DOMAIN      107    177       Peptidase_M10.
FT                                {ECO:0000259|Pfam:PF00413}.
FT   COILED       34     54       {ECO:0000256|SAM:Coils}.
FT   NON_TER     181    181       {ECO:0000313|Ensembl:ENSP00000441485}.
SQ   SEQUENCE   181 AA;  20482 MW;  D7E896F03D00BB91 CRC64;
     MMHLAFLVLL CLPVCSAYPL SGAAKEEDSN KDLAQQYLEK YYNLEKDVKQ FRRKDSNLIV
     KKIQGMQKFL GLEVTGKLDT DTLEVMRKPR CGVPDVGHFS SFPGMPKWRK THLTYRIVNY
     TPDLPRDAVD SAIEKALKVW EEVTPLTFSR LYEGEADIMI SFAVKGHSLA HAYPPGPGLY
     G
//