ID   F5GX75_HUMAN            Unreviewed;       118 AA.
AC   F5GX75;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 2.
DT   16-JAN-2019, entry version 54.
DE   SubName: Full=Vitronectin {ECO:0000313|Ensembl:ENSP00000440439};
DE   Flags: Fragment;
GN   Name=VTN {ECO:0000313|Ensembl:ENSP00000440439};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000440439, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000440439, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000440439}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
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DR   EMBL; AC002094; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF495704; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; F5GX75; -.
DR   jPOST; F5GX75; -.
DR   MaxQB; F5GX75; -.
DR   PeptideAtlas; F5GX75; -.
DR   PRIDE; F5GX75; -.
DR   Ensembl; ENST00000542029; ENSP00000440439; ENSG00000109072.
DR   UCSC; uc060cxt.1; human.
DR   EuPathDB; HostDB:ENSG00000109072.13; -.
DR   HGNC; HGNC:12724; VTN.
DR   OpenTargets; ENSG00000109072; -.
DR   eggNOG; KOG1565; Eukaryota.
DR   eggNOG; ENOG410XQ5D; LUCA.
DR   GeneTree; ENSGT00530000063751; -.
DR   ChiTaRS; VTN; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000109072; Expressed in 87 organ(s), highest expression level in right lobe of liver.
DR   ExpressionAtlas; F5GX75; baseline and differential.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:HPA.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR   GO; GO:0030247; F:polysaccharide binding; IEA:InterPro.
DR   GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   InterPro; IPR036024; Somatomedin_B-like_dom_sf.
DR   InterPro; IPR020436; Somatomedin_B_chordata.
DR   InterPro; IPR001212; Somatomedin_B_dom.
DR   Pfam; PF01033; Somatomedin_B; 1.
DR   PRINTS; PR00022; SOMATOMEDINB.
DR   SMART; SM00201; SO; 1.
DR   SUPFAM; SSF90188; SSF90188; 1.
DR   PROSITE; PS00524; SMB_1; 1.
DR   PROSITE; PS50958; SMB_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:F5GX75,
KW   ECO:0000213|PeptideAtlas:F5GX75};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    118       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003322971.
FT   DOMAIN       20     63       SMB. {ECO:0000259|PROSITE:PS50958}.
FT   NON_TER     118    118       {ECO:0000313|Ensembl:ENSP00000440439}.
SQ   SEQUENCE   118 AA;  13042 MW;  3B4ADE3B7679F674 CRC64;
     MAPLRPLLIL ALLAWVALAD QESCKGRCTE GFNVDKKCQC DELCSYYQSC CTDYTAECKP
     QVTRGDVFTM PEDEYTVYDD GEEKNNATVH EQVGGPSLTS DLQAQSKGNP EQTPVLKP
//