ID   F5GWR7_HUMAN            Unreviewed;      1505 AA.
AC   F5GWR7;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   13-FEB-2019, entry version 69.
DE   SubName: Full=Receptor-type tyrosine-protein phosphatase delta {ECO:0000313|Ensembl:ENSP00000380741};
GN   Name=PTPRD {ECO:0000313|Ensembl:ENSP00000380741};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000380741, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000380741, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E.,
RA   Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S.,
RA   Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R.,
RA   Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W.,
RA   Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G.,
RA   Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M.,
RA   Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W.,
RA   Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A.,
RA   Frankland J.A., French L., Fricker D.G., Garner P., Garnett J.,
RA   Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M.,
RA   Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S.,
RA   McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J.,
RA   Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R.,
RA   Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M.,
RA   Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M.,
RA   Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A.,
RA   Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W.,
RA   Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S.,
RA   Rogers J., Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000380741}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSP00000489169}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (DEC-2015) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein]
CC         + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136,
CC         Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48;
CC         Evidence={ECO:0000256|SAAS:SAAS01128831};
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC245202; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL137125; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL353638; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL356584; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL445926; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL451130; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL583805; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL590397; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL591133; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL596451; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL669908; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENST00000397617; ENSP00000380741; ENSG00000153707.
DR   Ensembl; ENST00000634360; ENSP00000489169; ENSG00000282932.
DR   UCSC; uc064scg.1; human.
DR   EuPathDB; HostDB:ENSG00000153707.15; -.
DR   HGNC; HGNC:9668; PTPRD.
DR   OpenTargets; ENSG00000153707; -.
DR   eggNOG; KOG4228; Eukaryota.
DR   eggNOG; COG5599; LUCA.
DR   GeneTree; ENSGT00940000153617; -.
DR   ChiTaRS; PTPRD; human.
DR   Proteomes; UP000005640; Chromosome 9.
DR   Bgee; ENSG00000153707; Expressed in 196 organ(s), highest expression level in forebrain.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR   CDD; cd00063; FN3; 4.
DR   Gene3D; 2.60.40.10; -; 7.
DR   Gene3D; 3.90.190.10; -; 2.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR000242; PTPase_domain.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   InterPro; IPR000387; TYR_PHOSPHATASE_dom.
DR   Pfam; PF00041; fn3; 3.
DR   Pfam; PF07679; I-set; 2.
DR   Pfam; PF00102; Y_phosphatase; 2.
DR   PRINTS; PR00700; PRTYPHPHTASE.
DR   SMART; SM00060; FN3; 4.
DR   SMART; SM00409; IG; 4.
DR   SMART; SM00408; IGc2; 3.
DR   SMART; SM00194; PTPc; 2.
DR   SMART; SM00404; PTPc_motif; 2.
DR   SUPFAM; SSF48726; SSF48726; 3.
DR   SUPFAM; SSF49265; SSF49265; 3.
DR   SUPFAM; SSF52799; SSF52799; 2.
DR   PROSITE; PS50853; FN3; 4.
DR   PROSITE; PS50835; IG_LIKE; 3.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Hydrolase {ECO:0000256|SAAS:SAAS01031415};
KW   Membrane {ECO:0000256|SAAS:SAAS00897767, ECO:0000256|SAM:Phobius};
KW   Protein phosphatase {ECO:0000256|SAAS:SAAS01031415};
KW   Proteomics identification {ECO:0000213|MaxQB:F5GWR7,
KW   ECO:0000213|PeptideAtlas:F5GWR7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00923712};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00897767,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00897767,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21   1505       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014571420.
FT   TRANSMEM    846    869       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       24    114       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      126    218       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      226    308       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      315    405       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      410    506       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      508    597       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      599    685       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      950   1205       Tyrosine-protein phosphatase.
FT                                {ECO:0000259|PROSITE:PS50055}.
FT   DOMAIN     1125   1196       TYR_PHOSPHATASE_2.
FT                                {ECO:0000259|PROSITE:PS50056}.
FT   DOMAIN     1237   1496       Tyrosine-protein phosphatase.
FT                                {ECO:0000259|PROSITE:PS50055}.
FT   DOMAIN     1414   1487       TYR_PHOSPHATASE_2.
FT                                {ECO:0000259|PROSITE:PS50056}.
FT   ACT_SITE   1146   1146       Phosphocysteine intermediate.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00160}.
FT   ACT_SITE   1437   1437       Phosphocysteine intermediate.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00160}.
SQ   SEQUENCE   1505 AA;  169444 MW;  48C36EB18900A17D CRC64;
     MVHVARLLLL LLTFFLRTDA ETPPRFTRTP VDQTGVSGGV ASFICQATGD PRPKIVWNKK
     GKKVSNQRFE VIEFDDGSGS VLRIQPLRTP RDEAIYECVA SNNVGEISVS TRLTVLREDQ
     IPRGFPTIDM GPQLKVVERT RTATMLCAAS GNPDPEITWF KDFLPVDTSN NNGRIKQLRS
     VSIGALQIEQ SEESDQGKYE CVATNSAGTR YSAPANLYVR VRRVPPRFSI PPTNHEIMPG
     GSVNITCVAV GSPMPYVKWM LGAEDLTPED DMPIGRNVLE LNDVRQSANY TCVAMSTLGV
     IEAIAQITVK ALPKPPGTPV VTESTATSIT LTWDSGNPEP VSYYIIQHKP KNSEELYKEI
     DGVATTRYSV AGLSPYSDYE FRVVAVNNIG RGPPSEPVLT QTSEQAPSSA PRDVQARMLS
     STTILVQWKE PEEPNGQIQG YRVYYTMDPT QHVNNWMKHN VADSQITTIG NLVPQKTYSV
     KVLAFTSIGD GPLSSDIQVI TQTGVPGQPL NFKAEPESET SILLSWTPPR SDTIANYELV
     YKDGEHGEEQ RITIEPGTSY RLQGLKPNSL YYFRLAARSP QGLGASTAEI SARTMQSMFA
     KNFHVKAVMK TSVLLSWEIP ENYNSAMPFK ILYDDGKMVE EVDGRATQKL IVNLKPEKSY
     SFVLTNRGNS AGGLQHRVTA KTAPDVLRTK PAFIGKTNLD GMITVQLPEV PANENIKGYY
     IIIVPLKKSR GKFIKPWESP DEMELDELLK EISRKRRSIR YGREVELKPY IAAHFDVLPT
     EFTLGDDKHY GGFTNKQLQS GQEYVFFVLA VMEHAESKMY ATSPYSDPVV SMDLDPQPIT
     DEEEGLIWVV GPVLAVVFII CIVIAILLYK RKRAESDSRK SSIPNNKEIP SHHPTDPVEL
     RRLNFQTPGS DDSGYPGNLH SSSMASHPPI PILELADHIE RLKANDNLKF SQEYESIDPG
     QQFTWEHSNL EVNKPKNRYA NVIAYDHSRV LLSAIEGIPG SDYVNANYID GYRKQNAYIA
     TQGSLPETFG DFWRMIWEQR SATVVMMTKL EERSRVKCDQ YWPSRGTETH GLVQVTLLDT
     VELATYCVRT FALYKNGSSE KREVRQFQFT AWPDHGVPEH PTPFLAFLRR VKTCNPPDAG
     PMVVHCSAGV GRTGCFIVID AMLERIKHEK TVDIYGHVTL MRAQRNYMVQ TEDQYIFIHD
     ALLEAVTCGN TEVPARNLYA YIQKLTQIET GENVTGMELE FKRLASSKAH TSRFISANLP
     CNKFKNRLVN IMPYESTRVC LQPIRGVEGS DYINASFIDG YRQQKAYIAT QGPLAETTED
     FWRMLWEHNS TIVVMLTKLR EMGREKCHQY WPAERSARYQ YFVVDPMAEY NMPQYILREF
     KVTDARDGQS RTVRQFQFTD WPEQGVPKSG EGFIDFIGQV HKTKEQFGQD GPISVHCSAG
     VGRTGVFITL SIVLERMRYE GVVDIFQTVK MLRTQRPAMV QTEDQYQFSY RAALEYLGSF
     DHYAT
//