ID F2Z3N2_HUMAN Unreviewed; 203 AA. AC F2Z3N2; DT 31-MAY-2011, integrated into UniProtKB/TrEMBL. DT 31-MAY-2011, sequence version 1. DT 16-JAN-2019, entry version 56. DE SubName: Full=Complement C2 {ECO:0000313|Ensembl:ENSP00000391354}; DE Flags: Fragment; GN Name=C2 {ECO:0000313|Ensembl:ENSP00000391354}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000391354, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000391354, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000391354} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL645922; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL671762; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F2Z3N2; -. DR jPOST; F2Z3N2; -. DR MaxQB; F2Z3N2; -. DR PeptideAtlas; F2Z3N2; -. DR PRIDE; F2Z3N2; -. DR Ensembl; ENST00000447952; ENSP00000391354; ENSG00000166278. DR UCSC; uc063njh.1; human. DR EuPathDB; HostDB:ENSG00000166278.14; -. DR HGNC; HGNC:1248; C2. DR OpenTargets; ENSG00000166278; -. DR eggNOG; KOG3627; Eukaryota. DR eggNOG; COG5640; LUCA. DR GeneTree; ENSGT00940000162934; -. DR ChiTaRS; C2; human. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000166278; Expressed in 96 organ(s), highest expression level in right lobe of liver. DR ExpressionAtlas; F2Z3N2; baseline and differential. DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. DR GO; GO:0006958; P:complement activation, classical pathway; IEA:InterPro. DR CDD; cd00033; CCP; 1. DR InterPro; IPR037568; Complement_C2. DR InterPro; IPR035976; Sushi/SCR/CCP_sf. DR InterPro; IPR000436; Sushi_SCR_CCP_dom. DR InterPro; IPR036465; vWFA_dom_sf. DR PANTHER; PTHR19325:SF387; PTHR19325:SF387; 2. DR Pfam; PF00084; Sushi; 1. DR SMART; SM00032; CCP; 2. DR SUPFAM; SSF53300; SSF53300; 1. DR SUPFAM; SSF57535; SSF57535; 2. DR PROSITE; PS50923; SUSHI; 2. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00302, KW ECO:0000256|SAAS:SAAS00887447}; KW Proteomics identification {ECO:0000213|PeptideAtlas:F2Z3N2}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 203 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003293653. FT DOMAIN 22 86 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 87 144 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DISULFID 115 142 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT NON_TER 203 203 {ECO:0000313|Ensembl:ENSP00000391354}. SQ SEQUENCE 203 AA; 21745 MW; EB1C6A84CDFF6B54 CRC64; MGPLMVLFCL LFLYPGLADS APSCPQNVNI SGGTFTLSHG WAPGSLLTYS CPQGLYPSPA SRLCKSSGQW QTPGATRSLS KAVCKPGHCP NPGISLGAVR TGFRFGHGDK VRYRCSSNLV LTGSSERECQ GNGVWSGTEP ICRQPYSYDF PEDVAPALGT SFSHMLGATN PTQKTKESLG RKIQIQRSGH LNLYLLLDCS QSV //