ID   FND10_HUMAN             Reviewed;         226 AA.
AC   F2Z333;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   31-MAY-2011, sequence version 1.
DT   13-FEB-2019, entry version 43.
DE   RecName: Full=Fibronectin type III domain-containing protein 10;
DE   Flags: Precursor;
GN   Name=FNDC10; Synonyms=C1orf233;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA   Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA   Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA   Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA   Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA   Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA   Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA   Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA   Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA   Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA   Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA   Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA   Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA   Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
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DR   EMBL; AL691432; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS55559.1; -.
DR   RefSeq; NP_001229588.1; NM_001242659.1.
DR   UniGene; Hs.528816; -.
DR   ProteinModelPortal; F2Z333; -.
DR   BioMuta; FNDC10; -.
DR   MaxQB; F2Z333; -.
DR   PaxDb; F2Z333; -.
DR   PRIDE; F2Z333; -.
DR   ProteomicsDB; 23877; -.
DR   Ensembl; ENST00000422725; ENSP00000389111; ENSG00000228594.
DR   GeneID; 643988; -.
DR   KEGG; hsa:643988; -.
DR   UCSC; uc021oes.2; human.
DR   CTD; 643988; -.
DR   EuPathDB; HostDB:ENSG00000228594.3; -.
DR   GeneCards; FNDC10; -.
DR   HGNC; HGNC:42951; FNDC10.
DR   neXtProt; NX_F2Z333; -.
DR   OpenTargets; ENSG00000228594; -.
DR   eggNOG; ENOG410JB9U; Eukaryota.
DR   eggNOG; ENOG410Z0X2; LUCA.
DR   GeneTree; ENSGT00550000076432; -.
DR   InParanoid; F2Z333; -.
DR   OMA; TENLMRP; -.
DR   OrthoDB; 1099174at2759; -.
DR   PhylomeDB; F2Z333; -.
DR   TreeFam; TF332961; -.
DR   ChiTaRS; FNDC10; human.
DR   GenomeRNAi; 643988; -.
DR   PRO; PR:F2Z333; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000228594; Expressed in 152 organ(s), highest expression level in right adrenal gland.
DR   Genevisible; F2Z333; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR034446; Fndc10.
DR   PANTHER; PTHR39233; PTHR39233; 1.
DR   Pfam; PF17742; DUF5579; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Glycoprotein; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN         1    226       Fibronectin type III domain-containing
FT                                protein 10.
FT                                /FTId=PRO_0000416238.
FT   SIGNAL        1     20       {ECO:0000255}.
FT   TOPO_DOM     21    182       Extracellular. {ECO:0000255}.
FT   TRANSMEM    183    203       Helical. {ECO:0000255}.
FT   TOPO_DOM    204    226       Cytoplasmic. {ECO:0000255}.
FT   DOMAIN       74    166       Fibronectin type-III.
FT   CARBOHYD     86     86       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    109    109       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
SQ   SEQUENCE   226 AA;  24218 MW;  F4A076C9226DA5FE CRC64;
     MRAPPLLLLL AACAPPPCAA AAPTPPGWEP TPDAPWCPYK VLPEGPEAGG GRLCFRSPAR
     GFRCQAPGCV LHAPAGRSLR ASVLRNRSVL LQWRLAPAAA RRVRAFALNC SWRGAYTRFP
     CERVLLGASC RDYLLPDVHD SVLYRLCLQP LPLRAGPAAA APETPEPAEC VEFTAEPAGM
     QDIVVAMTAV GGSICVMLVV ICLLVAYITE NLMRPALARP GLRRHP
//