ID   F2Z2Y9_HUMAN            Unreviewed;       289 AA.
AC   F2Z2Y9;
DT   31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   31-MAY-2011, sequence version 1.
DT   16-JAN-2019, entry version 60.
DE   SubName: Full=Signal-regulatory protein beta-2 {ECO:0000313|Ensembl:ENSP00000432656};
GN   Name=SIRPB2 {ECO:0000313|Ensembl:ENSP00000432656};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000432656, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000432656, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
RA   Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
RA   Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
RA   Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
RA   Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
RA   Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
RA   Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
RA   Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
RA   Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
RA   Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
RA   Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
RA   Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [2] {ECO:0000313|Ensembl:ENSP00000432656}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSP00000435045}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AL109658; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF510462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PeptideAtlas; F2Z2Y9; -.
DR   PRIDE; F2Z2Y9; -.
DR   Ensembl; ENST00000481731; ENSP00000432656; ENSG00000196209.
DR   Ensembl; ENST00000486775; ENSP00000435045; ENSG00000196209.
DR   UCSC; uc061uyq.1; human.
DR   EuPathDB; HostDB:ENSG00000196209.12; -.
DR   HGNC; HGNC:16247; SIRPB2.
DR   OpenTargets; ENSG00000196209; -.
DR   eggNOG; ENOG410J0R4; Eukaryota.
DR   eggNOG; ENOG410ZC9B; LUCA.
DR   GeneTree; ENSGT00940000163124; -.
DR   OrthoDB; 740991at2759; -.
DR   ChiTaRS; SIRPB2; human.
DR   Proteomes; UP000005640; Chromosome 20.
DR   Bgee; ENSG00000196209; Expressed in 112 organ(s), highest expression level in blood.
DR   ExpressionAtlas; F2Z2Y9; baseline and differential.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 2.
DR   SMART; SM00409; IG; 2.
DR   SMART; SM00408; IGc2; 2.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   PROSITE; PS50835; IG_LIKE; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:F2Z2Y9,
KW   ECO:0000213|PeptideAtlas:F2Z2Y9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     32       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        33    289       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014089699.
FT   DOMAIN       27    127       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      157    242       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   289 AA;  31581 MW;  30BEEA89FD311686 CRC64;
     MCSTMSAPTC LAHLPPCFLL LALVLVPSDA SGQSSRNDWQ VLQPEGPMLV AEGETLLLRC
     MVVGSCTDGM IKWVKVSTQD QQEIYNFKRG SFPGVMPMIQ RTSEPLNCDY SIYIHNVTRE
     HTGTYHCVRF DGLSEHSEMK SDEGTSVLVK GAGDPEPDLW IIQPQELVLG TTGDTVFLNC
     TVLGDGPPGP IRWFQGAGLS REAIYNFGGI SHPKETAVQA SNNDFSILLQ NVSSEDAGTY
     YCVKFQRKPN RQYLSGQGTS LKVKAKSTSS KEAEFTSEPA TEMSPTGLQ
//