ID   F2Z2G5_HUMAN            Unreviewed;        94 AA.
AC   F2Z2G5;
DT   31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   31-MAY-2011, sequence version 1.
DT   12-SEP-2018, entry version 45.
DE   SubName: Full=WAP four-disulfide core domain protein 3 {ECO:0000313|Ensembl:ENSP00000361713};
GN   Name=WFDC3 {ECO:0000313|Ensembl:ENSP00000361713};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000361713, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000361713, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
RA   Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
RA   Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
RA   Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
RA   Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
RA   Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
RA   Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
RA   Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
RA   Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
RA   Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
RA   Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
RA   Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [2] {ECO:0000313|Ensembl:ENSP00000361713}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2011) to UniProtKB.
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DR   EMBL; AL050348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; F2Z2G5; -.
DR   PRIDE; F2Z2G5; -.
DR   Ensembl; ENST00000372630; ENSP00000361713; ENSG00000124116.
DR   UCSC; uc061xir.1; human.
DR   EuPathDB; HostDB:ENSG00000124116.18; -.
DR   HGNC; HGNC:15957; WFDC3.
DR   OpenTargets; ENSG00000124116; -.
DR   eggNOG; ENOG410J2JX; Eukaryota.
DR   eggNOG; ENOG41123U9; LUCA.
DR   GeneTree; ENSGT00730000111454; -.
DR   Proteomes; UP000005640; Chromosome 20.
DR   Bgee; ENSG00000124116; Expressed in 106 organ(s), highest expression level in right testis.
DR   ExpressionAtlas; F2Z2G5; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0030414; F:peptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 4.10.75.10; -; 1.
DR   InterPro; IPR036645; Elafin-like_sf.
DR   InterPro; IPR008197; WAP_dom.
DR   InterPro; IPR029726; Wfdc3.
DR   PANTHER; PTHR19441:SF46; PTHR19441:SF46; 1.
DR   Pfam; PF00095; WAP; 1.
DR   PRINTS; PR00003; 4DISULPHCORE.
DR   SMART; SM00217; WAP; 1.
DR   SUPFAM; SSF57256; SSF57256; 1.
DR   PROSITE; PS51390; WAP; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25     94       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003293623.
FT   DOMAIN       24     70       WAP. {ECO:0000259|PROSITE:PS51390}.
SQ   SEQUENCE   94 AA;  10036 MW;  8B10E64EE9DC16A6 CRC64;
     MMLSCLFLLK ALLALGSLES WITAGEHGRG GDCPKVLVGL CIVGCVMDEN CQAGEKCCKS
     GCGRFCVPPV LPPKLTMNPN WTVRSDSELE IPVP
//