ID   F2Z2G4_HUMAN            Unreviewed;       137 AA.
AC   F2Z2G4;
DT   31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   31-MAY-2011, sequence version 1.
DT   16-JAN-2019, entry version 47.
DE   SubName: Full=WAP four-disulfide core domain protein 3 {ECO:0000313|Ensembl:ENSP00000361715};
GN   Name=WFDC3 {ECO:0000313|Ensembl:ENSP00000361715};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000361715, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000361715, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
RA   Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
RA   Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
RA   Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
RA   Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
RA   Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
RA   Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
RA   Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
RA   Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
RA   Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
RA   Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
RA   Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [2] {ECO:0000313|Ensembl:ENSP00000361715}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2011) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AL050348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; F2Z2G4; -.
DR   jPOST; F2Z2G4; -.
DR   PeptideAtlas; F2Z2G4; -.
DR   PRIDE; F2Z2G4; -.
DR   Ensembl; ENST00000372632; ENSP00000361715; ENSG00000124116.
DR   UCSC; uc061xiq.1; human.
DR   EuPathDB; HostDB:ENSG00000124116.18; -.
DR   HGNC; HGNC:15957; WFDC3.
DR   OpenTargets; ENSG00000124116; -.
DR   GeneTree; ENSGT00730000111454; -.
DR   Proteomes; UP000005640; Chromosome 20.
DR   Bgee; ENSG00000124116; Expressed in 106 organ(s), highest expression level in right testis.
DR   ExpressionAtlas; F2Z2G4; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0030414; F:peptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 4.10.75.10; -; 2.
DR   InterPro; IPR036645; Elafin-like_sf.
DR   InterPro; IPR008197; WAP_dom.
DR   InterPro; IPR029726; Wfdc3.
DR   PANTHER; PTHR19441:SF46; PTHR19441:SF46; 1.
DR   Pfam; PF00095; WAP; 2.
DR   PRINTS; PR00003; 4DISULPHCORE.
DR   SMART; SM00217; WAP; 2.
DR   SUPFAM; SSF57256; SSF57256; 2.
DR   PROSITE; PS51390; WAP; 2.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    137       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003294193.
FT   DOMAIN       26     68       WAP. {ECO:0000259|PROSITE:PS51390}.
FT   DOMAIN       69    113       WAP. {ECO:0000259|PROSITE:PS51390}.
SQ   SEQUENCE   137 AA;  14708 MW;  442B269CA1AC796E CRC64;
     MMLSCLFLLK ALLALGSLES WITAGEHAKE GECPPHKNPC KELCQGDELC PAEQKCCTTG
     CGRICRDIPK GRGGDCPKVL VGLCIVGCVM DENCQAGEKC CKSGCGRFCV PPVLPPKLTM
     NPNWTVRSDS ELEIPVP
//