ID   E9PSH8_HUMAN            Unreviewed;       201 AA.
AC   E9PSH8;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   16-JAN-2019, entry version 55.
DE   SubName: Full=T-cell surface glycoprotein CD3 epsilon chain {ECO:0000313|Ensembl:ENSP00000433975};
GN   Name=CD3E {ECO:0000313|Ensembl:ENSP00000433975};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000433975, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000213|PubMed:12522270}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=12522270; DOI=10.1073/pnas.2436191100;
RA   Salomon A.R., Ficarro S.B., Brill L.M., Brinker A., Phung Q.T.,
RA   Ericson C., Sauer K., Brock A., Horn D.M., Schultz P.G., Peters E.C.;
RT   "Profiling of tyrosine phosphorylation pathways in human cells using
RT   mass spectrometry.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:443-448(2003).
RN   [2] {ECO:0000213|PubMed:15144186}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=15144186; DOI=10.1021/ac035352d;
RA   Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M.,
RA   Peters E.C.;
RT   "Robust phosphoproteomic profiling of tyrosine phosphorylation sites
RT   from human T cells using immobilized metal affinity chromatography and
RT   tandem mass spectrometry.";
RL   Anal. Chem. 76:2763-2772(2004).
RN   [3] {ECO:0000213|PubMed:15592455}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=15592455; DOI=10.1038/nbt1046;
RA   Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,
RA   Zha X.M., Polakiewicz R.D., Comb M.J.;
RT   "Immunoaffinity profiling of tyrosine phosphorylation in cancer
RT   cells.";
RL   Nat. Biotechnol. 23:94-101(2005).
RN   [4] {ECO:0000313|Ensembl:ENSP00000433975, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [5] {ECO:0000213|PubMed:19690332}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA   Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K.,
RA   Rodionov V., Han D.K.;
RT   "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT   reveals system-wide modulation of protein-protein interactions.";
RL   Sci. Signal. 2:ra46-RA46(2009).
RN   [6] {ECO:0000313|Ensembl:ENSP00000433975}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AP001582; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PSH8; -.
DR   SMR; E9PSH8; -.
DR   jPOST; E9PSH8; -.
DR   PeptideAtlas; E9PSH8; -.
DR   PRIDE; E9PSH8; -.
DR   Ensembl; ENST00000528600; ENSP00000433975; ENSG00000198851.
DR   UCSC; uc058hxi.1; human.
DR   EuPathDB; HostDB:ENSG00000198851.9; -.
DR   HGNC; HGNC:1674; CD3E.
DR   OpenTargets; ENSG00000198851; -.
DR   eggNOG; ENOG410IYD1; Eukaryota.
DR   eggNOG; ENOG41123JN; LUCA.
DR   GeneTree; ENSGT00940000153312; -.
DR   ChiTaRS; CD3E; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000198851; Expressed in 107 organ(s), highest expression level in leukocyte.
DR   ExpressionAtlas; E9PSH8; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR015484; CD3_esu/gsu/dsu.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR003110; Phos_immunorcpt_sig_ITAM.
DR   PANTHER; PTHR10570; PTHR10570; 1.
DR   Pfam; PF02189; ITAM; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00077; ITAM; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS51055; ITAM_1; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:E9PSH8,
KW   ECO:0000213|PeptideAtlas:E9PSH8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    201       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003242942.
FT   TRANSMEM    121    145       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       34     99       IGc2. {ECO:0000259|SMART:SM00408}.
SQ   SEQUENCE   201 AA;  22564 MW;  446E300CDA13DF09 CRC64;
     MQSGTHWRVL GLCLLSVGVW GQDGNEEMAY KVSISGTTVI LTCPQYPGSE ILWQHNDKNI
     GGDEDDKNIG SDEDHLSLKE FSELEQSGYY VCYPRGSKPE DANFYLYLRA RVCENCMEMD
     VMSVATIVIV DICITGGLLL LVYYWSKNRK AKAKPVTRGA GAGGRQRGQN KERPPPVPNP
     DYEPIRKGQR DLYSGLNQRR I
//