ID   E9PSC7_HUMAN            Unreviewed;       158 AA.
AC   E9PSC7;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 8.
DT   16-JAN-2019, entry version 54.
DE   SubName: Full=Amyloid-like protein 2 {ECO:0000313|Ensembl:ENSP00000434059};
DE   Flags: Fragment;
GN   Name=APLP2 {ECO:0000313|Ensembl:ENSP00000434059};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000434059, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000434059, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000434059}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
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DR   EMBL; AP001183; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP003041; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PSC7; -.
DR   EPD; E9PSC7; -.
DR   jPOST; E9PSC7; -.
DR   PeptideAtlas; E9PSC7; -.
DR   PRIDE; E9PSC7; -.
DR   Ensembl; ENST00000533195; ENSP00000434059; ENSG00000084234.
DR   UCSC; uc058jcp.1; human.
DR   EuPathDB; HostDB:ENSG00000084234.16; -.
DR   HGNC; HGNC:598; APLP2.
DR   OpenTargets; ENSG00000084234; -.
DR   GeneTree; ENSGT00940000158814; -.
DR   ChiTaRS; APLP2; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000084234; Expressed in 249 organ(s), highest expression level in pigmented layer of retina.
DR   ExpressionAtlas; E9PSC7; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0008201; F:heparin binding; IEA:InterPro.
DR   Gene3D; 3.90.570.10; -; 1.
DR   InterPro; IPR008155; Amyloid_glyco.
DR   InterPro; IPR008154; Amyloid_glyco_extra.
DR   InterPro; IPR015849; Amyloid_glyco_heparin-bd.
DR   InterPro; IPR036454; Amyloid_glyco_heparin-bd_sf.
DR   PANTHER; PTHR23103; PTHR23103; 1.
DR   Pfam; PF02177; APP_N; 1.
DR   SMART; SM00006; A4_EXTRA; 1.
DR   SUPFAM; SSF56491; SSF56491; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:E9PSC7,
KW   ECO:0000213|MaxQB:E9PSC7, ECO:0000213|PeptideAtlas:E9PSC7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     31       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        32    158       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5008413960.
FT   DOMAIN       67    158       A4_EXTRA. {ECO:0000259|SMART:SM00006}.
FT   NON_TER     158    158       {ECO:0000313|Ensembl:ENSP00000434059}.
SQ   SEQUENCE   158 AA;  17226 MW;  5A4055D382AD61F7 CRC64;
     MAATGTAAAA ATGRLLLLLL VGLTAPALAL AGYIESSQIC CSPRSFLIST LKCLIVDEIN
     ALAANAGTGF AVAEPQIAMF CGKLNMHVNI QTGKWEPDPT GTKSCFETKE EVLQYCQEMY
     PELQITNVME ANQRVSIDNW CRRDKKQCKS RFVTPFKC
//