ID   E9PS89_HUMAN            Unreviewed;        98 AA.
AC   E9PS89;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   05-DEC-2018, entry version 45.
DE   SubName: Full=Beta,beta-carotene 9',10'-oxygenase {ECO:0000313|Ensembl:ENSP00000435869};
GN   Name=BCO2 {ECO:0000313|Ensembl:ENSP00000435869};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000435869, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000435869, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000435869}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000256|SAAS:SAAS00853222};
CC   -!- SIMILARITY: Belongs to the carotenoid oxygenase family.
CC       {ECO:0000256|RuleBase:RU003799, ECO:0000256|SAAS:SAAS00853223}.
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DR   EMBL; AP002884; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; E9PS89; -.
DR   PeptideAtlas; E9PS89; -.
DR   Ensembl; ENST00000531003; ENSP00000435869; ENSG00000197580.
DR   UCSC; uc058hih.1; human.
DR   EuPathDB; HostDB:ENSG00000197580.11; -.
DR   HGNC; HGNC:18503; BCO2.
DR   OpenTargets; ENSG00000197580; -.
DR   eggNOG; KOG1285; Eukaryota.
DR   eggNOG; COG3670; LUCA.
DR   GeneTree; ENSGT00940000155169; -.
DR   ChiTaRS; BCO2; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000197580; Expressed in 158 organ(s), highest expression level in right adrenal gland.
DR   ExpressionAtlas; E9PS89; baseline and differential.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:InterPro.
DR   InterPro; IPR004294; Carotenoid_Oase.
DR   PANTHER; PTHR10543; PTHR10543; 1.
DR   Pfam; PF03055; RPE65; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Iron {ECO:0000256|SAAS:SAAS00853218};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00853220};
KW   Proteomics identification {ECO:0000213|MaxQB:E9PS89,
KW   ECO:0000213|PeptideAtlas:E9PS89};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18     98       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003242935.
SQ   SEQUENCE   98 AA;  11142 MW;  69BAC2591DBBE4B8 CRC64;
     MFFRVFLHFI RSHSATAVDF LPVMVHRLPV FKRYMGNTPQ KKAVFGQCRG LPCVAPLLTT
     VEEAPRGISA RVWGHFPKWL NGSLLRIGPG KFEFGKDK
//